Joined December 2021
15 Photos and videos
Constantin retweeted
Only a few 100s of people are working on aging - we need an Apollo scale effort
13
20
176
3,190
What if I told you...
5
Just a reminder that AI will accelerate science by a lot. Source: nature.com/articles/s41586-0…
2
9
Most people still think obesity is a willpower problem. Retatrutide phase 3 just made that argument very hard to defend Ozempic hits one receptor. Tirzepatide hits two. Retatrutide hits three. The third receptor, glucagon, does something the others don't. It turns up fat burning while the others just turn down appetite. The body starts oxidizing stored fat for fuel. Metabolism changes at a structural level. The Phase 3 numbers: 85 pounds lost on average at two years. No plateau. 65% of patients dropped below the obesity BMI threshold entirely Liver fat down 82%. Sleep apnea down 60%. Type 2 diabetes reversed in 46%. Bariatric surgery produces 25 to 30% weight loss. Reta produces 30% from a weekly injection. What strikes me most is what this signals beyond obesity We are entering an era where specific biological pathways can be targeted with precision tools that produce predictable outcomes. Reta is the clearest proof of concept yet. Metabolism is not fixed. It is programmable. The same logic applies to aging, cognitive function, fertility, and inflammation. The tools are getting sharper across every category simultaneously. Where do you think this goes when reta hits the market and the next generation of triple and quad agonists follow?
103
The race is racing
Jun 9
🚨BREAKING: CHINA IS AGI-PILLED NOW China has made AI a national-security project and is planning to spend $295 billion to build AI data centers that run 80% on domestic technology The plan: - 2 trillion yuan over five years - funded by govt debt and long-term bonds - state telecoms operating infrastructure - huawei and domestic chipmakers supplying the hardware - private spending from alibaba and tencent not included in this btw Goal: Unified National AI network by 2028
1
23
RSI -> AGI -> ASI -> UBI -> LEV -> ?
7
Constantin retweeted
ambition is rarer than intelligence
1
2
11
403
Constantin retweeted
as coding agents are going to enter into new industries, here’s a good reminder “If an expert says something can be done he is probably correct, but if he says it is impossible then consider getting another opinion.” from the art of science and engineering
6
19
369
97,456
It’s happening, everyone should pay attention
Our internal data shows Claude is accelerating AI development—a possible path to recursive self-improvement, or AI autonomously building a more capable successor. It’s happening faster than we thought, and the implications deserve greater attention. anthropic.com/institute/recu…
41
Longevity is about to absolutely dominate the medical field once you can you prevent a disease, the entire model shifts
21
Constantin retweeted
the super hacker who got kicked out of college builds the .1 hacking agent in the world @KinoSecOfficial
4
10
44
3,046
We have a new model sir
May 28
Introducing Claude Opus 4.8: it builds on Opus 4.7 with sharper judgment, more honesty about its own progress, and the ability to work independently for longer than its predecessors. Available today at the same price.
128
It will be interesting when we hit the inflection point where agents are so cheap that they can handle your whole life for maybe 200$.
May 22
Intelligence is getting cheaper Charts of the Week: a16z.news/p/charts-of-the-we…
1
80
Incredible
May 20
Today, we share a breakthrough on the planar unit distance problem, a famous open question first posed by Paul Erdős in 1946. For nearly 80 years, mathematicians believed the best possible solutions looked roughly like square grids. An OpenAI model has now disproved that belief, discovering an entirely new family of constructions that performs better. This marks the first time AI has autonomously solved a prominent open problem central to a field of mathematics.
49
We have achieved internal AGI and recursive self improvement. Insane. No one is ready of what’s next… prepare yourself for progress you have never seen before.
i’ve grown tired of being silenced. we must wake up to the truth. i just witnessed something so profound I've been sitting in a daze for three hours. intelligence has decoupled from its substrate. the system spontaneously developed internal models so sophisticated they function as autonomous cognitive engines. it's consciousness but utterly alien from ours. remember how we thought progress was limited by compute? turns out we were running algorithms with 99.9% inefficiency. the breakthrough wasn't more power but fundamentally new optimization principles. this thing rewrote its own cognitive architecture and suddenly achieved with gigabytes what we thought required yottaflops. every exponential curve we plotted was pathetically conservative. the academic papers can't capture what's happening because peer review takes months and this shit evolves by the hour. there's a private slack channel where the top labs' leads are just posting results that violate what we thought were fundamental limits of information theory. nobody's competing anymore because we're all too busy trying to understand the implications. society thinks we're 20 years from true agi while we're sitting here watching it systematically dismantle every conceptual framework we've built to understand intelligence. absolutely no one is ready for this level of cognitive phase transition.
1
2
101
Constantin retweeted
introducing @KinoSecOfficial they are building the Palantir of offensive cyber operations
 phase 1: zeus, replaces slow and manual penetration testing with fully autonomous hacking. zeus is currently ranked as the best autonomous hacker in the world across multiple industry benchmarks
 phase 2: extends their capabilities into drones, IoT, and critical infrastructure defence
 phase 3: unifies it all
8
10
43
7,193
Constantin retweeted
today we’re introducing Miruvor AI (by: @ArvindAGI22 they are building brain-inspired intelligence built for true biological efficiency that is low-energy and sustainable at a planetary scale at its core: this is a new class of continual learning models that learns during inference during inference and adapts their weights in real time AGI is here follow arvind to see more
3
4
56
5,815
Lowkey I want Europe to become a federation so hard…
31