The Computational Modeling of Biological Systems (SysMod) Community of Special Interest (COSI) of the International Society for Computational Biology (ISCB)

Joined November 2015
139 Photos and videos
Chiara Damiani et al. combine data-driven and knowledge-based modeling to study tumor metabolism from high-resolution spatial transcriptomics data and apply the universal spFBA methodology in spatially resolved contexts. npj Systems Biology & Applications doi.org/10.1038/s41540-026-0…
2
159
24 Dec 2025
🎄✨ Happy Holidays to all of you from SysMod! ✨🎄 We can’t wait to see you at our conference, July 12–16, 2026, in Washington, D.C., USA, to connect, share knowledge & continue advancing innovation in computational biology—mark your calendars & stay tuned for updates!
4
89
17 Dec 2025
We are deeply saddened by the passing of @ChaouiyaC (1969–2025) – a cherished member of our community and coordinator (2018-2022), contributing with expertise & kindness. Her work on logical modeling of regulatory networks & dedication to SysMod left a lasting mark. We miss her.
2
4
206
24 Nov 2025
SysMod just turned 10! 🎉 We continue to serve our community of systems modelers and researchers in computational systems biology. Join us and get involved, for instance, in our annual meetings at the ISMB conference. #MyXAnniversary
4
441
SysMod retweeted
13 Aug 2025
The results of the ISCB Leadership vote are in!  Terms for the ISCB President-Elect and ISCB Vice President will start on January 21, 2026.
3
6
26
2,568
24 Jul 2025
🎉 Congratulations to our poster prize winners of SysMod at #ISMBECCB2025! 🥁 Prizes: local food and beverages, and, as the first priue, a 20% discount to the 2026 meeting! ➢ 1st: Yanjun Liu @uniofgalway ➢ 2nd: Rupinder Kaur @kieluni ➢ 3rd: Sebastian Huß at the Uni Potsdam
1
5
236
22 Jul 2025
Chiara Damiani (University of Milano-Bicocca) wraps up the 2025 SysMod Meeting at #ISMBECCB2025 with closing remarks and announcing the poster awards. Huge thanks to all participants and speakers for making it a vibrant showcase of systems biology! See you at #ISMB2026!
3
259
22 Jul 2025
“TFvelo: gene regulation–inspired RNA velocity estimation” by Jiachen Li (Institute of Process Engineering) presents TFvelo—a tool that models RNA velocity without splicing info by leveraging regulatory networks, inferring cell trajectories & pseudotime. #ISMBECCB2025
1
3
225
22 Jul 2025
Marek Kimmel (@RiceUniversity) on “Computational Modeling of Shortening and Reconstruction of Telomeres”: a stochastic branching-process model captures yeast telomere decay, cell death & alternate lengthening of telomeres-driven rebuilding—for human aging & cancer. #ISMBECCB2025
3
160
22 Jul 2025
Koichiro Majima (@sciencetokyo_en) shows new spatiotemporal VAE models of continuous single-cell tissue dynamics—tracking growth, reorganization & gene expression from discrete snapshots. Applied to mouse embryogenesis, it reveals hidden developmental trajectories. #ISMBECCB2025
4
142
22 Jul 2025
Erick Armingol presents at #ISMBECCB2025: scCellFie, a tool to infer metabolic activities from single-cell & spatial transcriptomics. Scaling to 30M cells, it maps human metabolism and uncovers rewired pathways in endometrium, endometriosis, and cancer. #SingleCell #Metabolism
1
4
176
22 Jul 2025
Using single-cell time-lapse microscopy and agent-based #modeling, Ati Ahmad et al. (@UWaterloo) calibrate how colicin-producing E. coli kill susceptible strains in microfluidic traps—revealing how spatial structure shapes microbial competition #Microbiology #ISMBECCB2025
2
230
22 Jul 2025
Next, Sayali Anil Alatkar (@UWMadison) presents ARTEMIS—a generative model combining autoencoders & Schrödinger Bridges at #ISMBECCB2025, aiming to predict continuous gene expression, cell population, and perturbation dynamics from time-series single-cell data. #SingleCell #AI
1
4
148
22 Jul 2025
Now, Bi-Rong Wang (TU Eindhoven) presents at #ISMBECCB2025 how active learning logic-ODE models decode CXCL9 regulation in pancreatic cancer. This approach speeds discovery of drug combos to boost T cell recruitment & tackle immune exclusion. #SystemsBiology #CancerImmunology
5
188
22 Jul 2025
Using multi-objective reinforcement learning, Nhung Duong et al. (Hanoi University of Pharmacy) modeled JAK/STAT pathway for cancer therapies to balance tumor control, immune health, resistance & toxicity to reveal optimal strategies, towards personalized treatment. #ISMBECCB2025
1
7
207
22 Jul 2025
Arnau Montagud introduces a community benchmark to compare leading off-lattice multiscale modeling tools (BioDynaMo, Chaste, PhysiCell, TiSim) for virtual human twin research, revealing performance gaps & needs for gold standards to advance biomedical simulations. #ISMBECCB2025
6
227
22 Jul 2025
Jasmin Fisher, a professor at the @UCL, is delivering the second keynote talk in a full house on how computational models can decode complex cancer signalling networks at #ISMBECCB2025.
1
7
209
22 Jul 2025
Virtual tumors are helping fight hard-to-treat cancers. Data-driven models of cancer signaling predict resistance, reveal mechanisms, & guide patient-specific therapies for TNBC, lung cancer, melanoma & glioblastoma. #CancerResearch #SystemsBiology
4
74