Our work on de novo design of #GPCR “exoskeleton armor” is out on the #ChineseNewYear Eve! Take a look at my article! nature.com/articles/s41586-0…

I’m thrilled to share our latest work in Cell! We developed a GoA pathway–selective 5-HT1AR agonist that may achieve rapid antidepressant effects by bypassing DRN autoreceptor feedback. Huge thanks to my amazing team and collaborators! cell.com/cell/fulltext/S0092…

Read my latest #research on #opioid receptor and #GPCR signaling, published with @SpringerNature in @cell_res. Read and share here: rdcu.be/eOGAg

Glad to share our recent work! Li-Nan is an awesome PhD student and now is looking for a postdoc position. Proton perception and activation of a proton-sensing GPCR: Molecular Cell cell.com/molecular-cell/full…

Here, we present a set of 12 assemblies of the apelin receptor, including dimeric apo, monomeric, and dimeric intermediate and active states. Image created by Grok! Dynamic Monomer-Dimer Transition in Ligand-induced Apelin Receptor Activation biorxiv.org/content/10.1101/…

when Cell turns 100? @CellCellPress Cell after 50: Cell cell.com/cell/fulltext/S0092…

The first independent publication from the Berndsen lab @Mizzou_Biochem in collaboration with my colleague @CKeithCassidy is now peer reviewed and online at @Nature !! rdcu.be/d3kfg Resolving a many decades-old challenge, we determined the complete structure of apolipoprotein B100 on the surface of its native #LDL particle using a combination single-particle #cryoEM, #AlphaFold2, and molecular dynamics refinement methods. At ~550 kDa, with ~4.6k residues of mostly extended amphipathic domains, #ApoB is one of the largest and most complex proteins in the genome. Our structure provides insight into lipoprotein synthesis, the structural changes involved in the catabolic conversion from VLDL to LDL, and the nature of disease causing mutations involved in diseases such as #FamilialHypercholesterolemia. The main change from the preprint is the addition of extensive chemical crosslinking data, which validate many of the lower-resolution contacts we observed between the C-terminal inserts and lends support to our proposed model for conformational changes on larger LP particles. With the structure of apoB finally revealed, a new era in lipoprotein research begins were highly precise and targeted structural, genetic, and computational studies are now possible! We have many plans and are excited for what the future of this field holds, so stayed tuned!!

Excited to join the Editorial Board of @PLOSBiology, the #PLOS flagship journal in the Life Sciences, that's blazing a trail in support of selective, equitable #OpenScience and reaching global audiences to help advance science faster.

Interesting snapshot of pre-coupled G protein to a GPCR in "inactive" state biorxiv.org/content/10.1101/…

Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy biorxiv.org/content/10.1101/…

今度はGPCR workshopの情報が出てますね。今年の年末にスペインで開催されるという話を聞いていましたが、どうやらなくなった模様です（？）（何があったのだろう。。） 来年12月にハワイということで、個人的にはICRPと年がずれてくれて助かりました。今から楽しみです。 gpcrworkshop.com

Glad to share our recent work!! Thanks for the help from computer scientist！ Molecular Determinant Underlying Selective Coupling of Primary G‐Protein by Class A GPCRs - Shen - Advanced Science - Wiley Online Library onlinelibrary.wiley.com/doi/…

Cell: Structure-based design of non-hypertrophic apelin receptor modulator cell.com/cell/fulltext/S0092…

Happy to share our latest work, seeing the high-res picture of the inactive aGPCR Conformational transitions and activation of the adhesion receptor CD97 authors.elsevier.com/a/1iPd9…

Snapshot of the cannabinoid receptor 1-arrestin complex unravels the b... authors.elsevier.com/c/1iFnL…

This is one of the most interesting GPCR structures I can think of - demonstrating how GPR120 can recognize and then respond differently to unsaturated bonds in fatty acid ligands. Amazing! science.org/doi/10.1126/scie…