This year at
#BNS25 I’ve showed my work on brain injury. Following my work the sustained and increased expression of Bax and survivin in post-mortem cases of traumatic brain injury (
#TBI), ranges from as early as 15 minutes to 16 years post-injury, highlighting the prolonged impact of TBI on
#apoptotic and survival pathways in the brain. Bax, a pro-apoptotic protein, promotes neuronal
#celldeath, while
#survivin, an anti-apoptotic protein, counteracts this process to support cell survival. Their concurrent expression suggests a dynamic and persistent attempt by the brain to balance injury-induced cell death with neuroprotection, even in chronic phases of TBI. This prolonged molecular response may contribute to ongoing neurodegeneration, inflammation, and repair mechanisms, offering insights into the long-term pathophysiology of TBI and potential therapeutic targets. This work was possible thanks to the donors and their families as well as the teams at
@LNDBrainBank,
@KingsCollegeLon and
@KingsIoPPN