Deep Tech VC 🚀 | Managing Partner @alumniventures | 2x Founder CEO | Ex-Innovation @Nike 👟 | @georgetown @berkeleyhaas 📚 | Opinions mine.

Joined August 2013
116 Photos and videos
Matt Caspari retweeted
Coming up at Tech Weekend June 2026: VC Panel: How VCs Make Decisions — From First Meeting to Term Sheet What really happens on the other side of the table when you're raising. This session covers: • What VCs decide about you before you start pitching • Why most good meetings don't turn into checks — and what changes that • What happens inside the partnership meeting after you leave the room • How to run a process so multiple investors move at the same time • How to read investor feedback when they're not being direct • What to negotiate on a term sheet, and what doesn't matter • For international founders: how to set up, position, and raise in the US Meet the Speakers 🎤 Matt Caspari @deeptechvc — Managing Partner, @alumniventures Investment Focus: Deep Tech from seed to pre-IPO Matt leads the Deep Tech and Strawberry Creek Ventures funds at Alumni Ventures, backing mission-driven founders across agriculture, AI, aviation, biotech, defense, energy, longevity, robotics, and space. A two-time venture-backed founder/CEO — including founding CEO of Aurora Biofuels (100 employees, $100M raised, acquired by Reliance Industries) — and a former leader on Nike's innovation team. 🎤 Victoria Smith — Partner at @ZacuaVentures Investment Focus: PropTech, ConTech, AI-native software, marketplaces, consumer & enterprise SaaS Victoria was an early hire at both Jackson Square Ventures and Zacua Ventures, where she led pre-seed investments in software for the built environment and ran Launchpad, JSV's earliest-stage vehicle for student-led startups. A former founder of an acquired company herself, she brings both the operator's and the investor's perspective to the table. 🎤 Allen Smith — Founder & Managing Partner, @Musa_Capital Investment Focus: Early-stage, tech-enabled businesses built by diverse founding teams Allen is Founder and Managing Partner at Musa Capital, an early-stage firm investing in diverse founding teams building tech-enabled businesses. He brings 10 years in go-to-market and sales operations from LinkedIn, Microsoft, and Waterstone Management Group, where he built and scaled major commercial initiatives. Moderator 🎤 Gary Gardner — Founder & CEO, Lead Generation Hubs Gary is a seasoned sales leader and Army Reserve Captain building a platform to empower sales professionals. With a PhD in Organization and Management and experience leading high-performing teams as VP of Sales at Hyqoo and Toptal, he brings both academic and practical expertise to business development. 📅 Date & Time: Thursday, June 18, 2026 | 10:00 AM – 11:00 AM 📍 Location: 75 Arbor Road, Menlo Park, CA Who should attend? If you're fundraising now — or about to start — and want to understand how investors actually decide, from the first meeting through the partnership discussion to the term sheet, this session is for you. International founders raising in the US will find it especially useful. Details and sign up at: techweekend.org
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Matt Caspari retweeted
With a nod to @leopoldasch, we're releasing Biological Awareness - our musings on the next decade at the frontiers of AI and life sciences. Six ideas we explore: → Task-specific experimental tokens are the new gold in biology → Bio AI data factories will pioneer new business models → Smoothing out the jagged frontier for pharma enterprises is where fortunes will be made → Clinical trial intelligence will be financialized before it is operationalized → The bioweapons threat is real, accelerating, and underpriced → The BIOSECURE Act will fundamentally reshape supply chains 2026 marks ten years of Obvious investing at this intersection. A lot has happened. Even more is coming. Big thanks to: @kyosu, @syntenyAI, @GabriCorso, @inductivebio, @mithrl_ai , @instancebio , @strangemonad, @exnx and many others for their help!
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Matt Caspari retweeted
May 19
I'm super excited to announce our $7.2M seed round a strategic collaboration with @PacBio! Together, we'll be generating long-read, bulk-RNA sequencing directly from patient tumours spanning multiple cancer indications. This is extremely rich data that will be used to further train and evaluate our models. @blankbio_, we are focused on training RNA foundation models that can learn and predict disease progression and treatment response in patients. These are the biological insights that will enable us to design smaller, more efficient clinical trials with higher success rates. Huge thank you to all of our investors who have been amazing supporters from the beginning. For more details, please check out the links below. Press release: blank.bio/seed-announcement Blog from the team: blank.bio/accelerate-clinica… We're hiring: ycombinator.com/companies/bl…
Today, we’re excited to announce our $7.2M seed round alongside a strategic collaboration with @PacBio! At Blank Bio, we help pharma make more informed decisions in clinical trials by capturing the biology that makes each patient’s tumour unique. We do this by training RNA foundation models to learn the patterns that shape disease progression and how patients respond to treatment. In our collaboration with @PacBio, we will generate long-read, bulk RNA-sequencing data from patient tumour samples across multiple indications. This dataset will be used to further train and evaluate our models. Our models are currently focused on two main applications. First, we predict how a patient’s disease is likely to progress over time from their molecular profile. Through the FDA-recommended approach of covariate adjustment, these RNA prognostic scores can help clinical development teams design trials that reach statistical power with fewer patients. Second, we’re working to help pharma teams understand biological differences between patients so they can identify who is most likely to respond to a given therapy. We are thankful to @definevc, @LeonisCapital, Nova Threshold, @ripple_ventures, @SignalFire, @ycombinator, and other investors for being early supporters in our vision. This financing will support the continued development of our foundation models, expanded collaborations with pharma, and growing our patient-level datasets. Read the press release: blank.bio/seed-announcement Read the blog from the team: blank.bio/accelerate-clinica… Learn more about Blank Bio: blank.bio
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Matt Caspari retweeted
I've been posting less and writing more. I've found it helpful to slow everything down and take the time for proper reflection. Today I'm putting out a review of the last quarter: Growing AI Anxiety Turning LLMs into Computers Anthropic and the Department of War Iranian Conflict The Incoming Techlash It's easy to feel like the response to this is for tech to "get tough" But I want to encourage the next generation to do something simple: keep your soul
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Matt Caspari retweeted

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Matt Caspari retweeted
Silent Ventures is privileged to co-lead @SwarmAero's Series A alongside our friends at @TwoSigmaVC. We're happy to welcome @ScribbleVC @friendsfamcap and several others to this journey. Swarm has quietly developed one of the most advanced Group 5 drones in market, in addition to a leading autonomous command and control platform. These capabilities are critical for US defense and Western sovereignty. Congrats to the founding team on this achievement. Americans are safer because of the good people at Swarm. cc @foundersfund @khoslaventures @constructcap @MaCVentureCap @QuietCapital @alumniventures
Modern conflicts are decided in the air. Swarm Aero is building a radically effective way to scale air power. We're proud to share that we've raised $35 million in Series A funding, led by @TwoSigmaVC and @SilentVentures and joined by our seed investors @khoslaventures, @ScribbleVC, @friendsfamcap, @constructcap, @coatuemgmt, @foundersfund, @alumniventures, and @MaCVentureCap! This brings total capital raised to $59M to accelerate the deployment of our large UAV and the swarm software that enables drones to be controlled at scale. While smaller drones pack smaller punches and require assistance to get to the fight, our large, multimission UAV can cover long distances and defeat high-value targets. Designed to manufacture at unprecedented volume and cooperate with superhuman dexterity, our UAV achieves asymmetric impact at dramatically lower cost than traditional aircraft. The future world order depends on who controls air power. Swarm is building the technologies needed for deterrence and dominance in the 21st century. And we’re hiring! Read more in @axios' Future of Defense exclusive on the raise (thank you @demarest_colin!) and our press release: axios.com/2026/03/11/swarm-a… businesswire.com/news/home/2…
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Matt Caspari retweeted
Modern conflicts are decided in the air. Swarm Aero is building a radically effective way to scale air power. We're proud to share that we've raised $35 million in Series A funding, led by @TwoSigmaVC and @SilentVentures and joined by our seed investors @khoslaventures, @ScribbleVC, @friendsfamcap, @constructcap, @coatuemgmt, @foundersfund, @alumniventures, and @MaCVentureCap! This brings total capital raised to $59M to accelerate the deployment of our large UAV and the swarm software that enables drones to be controlled at scale. While smaller drones pack smaller punches and require assistance to get to the fight, our large, multimission UAV can cover long distances and defeat high-value targets. Designed to manufacture at unprecedented volume and cooperate with superhuman dexterity, our UAV achieves asymmetric impact at dramatically lower cost than traditional aircraft. The future world order depends on who controls air power. Swarm is building the technologies needed for deterrence and dominance in the 21st century. And we’re hiring! Read more in @axios' Future of Defense exclusive on the raise (thank you @demarest_colin!) and our press release: axios.com/2026/03/11/swarm-a… businesswire.com/news/home/2…
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Matt Caspari retweeted
Sharing this publicly––hope it's not needed but helps you if it is. Lux team sent this memo to all Lux family founders yesterday "We send notes like this not because something is wrong, but because the COST of preparation is trivially LOW and the VALUE of being positioned well is asymmetrically HIGH. This isn’t a macro call. It’s a set of observations about correlated risks that are worth your attention. And a set of practical suggestions regardless of whatever happens next."
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Matt Caspari retweeted
Some benchmarks for deep tech company fundraising across 900 rounds raised by US startups in 2025. Scattered thoughts: Deep tech companies took in 36% of total funding this year to Carta companies. That's up from only 17% a decade ago. Deep tech is riding a wave. There has been a resurgence of interest into specific deep tech categories lately (American Dynamism, defense aerospace, etc). Maybe some of that is the idea that moats in software are declining in the age of AI. Not every deep tech category had a good year. Medical Device funding continued to struggle in 2025 and IoT was flat. While deep tech is not quite as SF-centric as software startups tend to be, this data still reflects more rounds in the Bay Area than anywhere else. Deep tech companies, particularly Biotech, used to favor convertible notes over SAFEs. That has flipped in recent years, with every deep tech sector now solidly seeing more volume at early stages on SAFEs. AI is in this data but not to the same extent as in software-only companies. Deep tech startup fundraising is usually more dilutive at the early stages than software-only fundraising (meaning a founder will have to sell more of the company for a similar amount of money). Interestingly, the total amount of capital needed for a deep tech startup to make it all the way to IPO is not usually much more than the total capital needed for a software startup. So more dilutive upfront, but not always more capital-intensive. Regulatory concerns play a bigger role in many deep tech sectors than in pure software, but interaction with the government on state and federal levels is getting fractionally easier for some over time.
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Join Us in Deep Tech Venture Capital! We're recruiting Venture Fellows to work with us throughout 2026. 👉 Learn more and apply here before the January 5 deadline: job-boards.greenhouse.io/alu… Please share this with anyone who might be interested! 🚀
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Matt Caspari retweeted
We just raised a $20M seed round to build the largest bank in the world. Kontigo crossed $30M in annual revenue, $1B in payment volume, and 1M users in under 12 months, with a team of six engineers and one designer. We are the fastest-growing stablecoin neobank in the world. Any individual or business on earth can: - Earn 10% yield on their digital dollars. - Get a stablecoin card with bitcoin cashback. - Activate a USDT credit line. - Invest in tokenized U.S. stocks. - Open an international account for free. This is a real-world use case of crypto. No casinos, no jargon, just normal people who don’t even know what USDC or USDT is. We’re, once and for all, democratizing access to basic finance and giving 4.8 billion people the ability to hold a stable currency (USDC) alongside a wealth creator (BTC). The equation is simple: they invest in BTC, they hold USDC, and they spend in local stablecoins. More than a thousand businesses and a million users are already doing this. They connect their local bank, card, or payment method and start moving funds globally, instantly, and without limits. No matter the corridor. U.S. ↔ LatAm, LatAm ↔ Asia, Asia ↔ Europe, U.S. ↔ Africa, Europe ↔ LatAm. We’ve them all. Just imagine how much faster Revolut would’ve grown if they didn’t have to get individual banking licenses in each of the 50 countries they’ve launched in. That’s @kontigo_app You simply can’t outcompete the fact that our backend, database, and infrastructure run on the freaking blockchain: 24/7, at a fraction of the cost, open, permissionless. It’s a whole new game, different incentives, and a new technological paradigm. Thanks to all the early supporters! We’re proud to partner with the best: @t_blom & @harjtaggar from @ycombinator ; @hthieblot & @FurqanR from @fdotinc ; @davefontenot from @hf0 ; @HoolieG from @cbventures & @jessepollak from @base ; Saurabh and Grace from DST ; also @GoodwaterCap @Soma_Capital @pioneer_fund @transposevc @alumniventures @m_franceschetti @EvanWeb3 @metavarce @davecyen Tom Brown, Oliver Jung, Ricardo Schäfer, Andrej Henkler, Yi Shi, Philippe Teixeira. Some people said the fintech era was over…
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Matt Caspari retweeted
The top nine most valuable companies in the world were all formed on the West Coast of the United States. The top eight are tech companies.
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Great startup pitch event over dim sum in SF! Thanks @Jason, the @LAUNCH team, and all the founders who pitched. 🚀
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