We study genomics and viral diseases, especially HIV and now feat. COVID-19, and spend a lot of time wondering what makes viruses cause disease.

Joined June 2015
35 Photos and videos
3 Jul 2024
Got milk? Interested in citizen science? We are starting to look for grocery store milk and cream from certain dairy processors (can be identified from labeling on the carton) from around Wisconsin as part of our ongoing H5N1 influenza monitoring. DM @dho_lab if interested.
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3 Jun 2021
Interested in SARS-CoV-2 sequencing? Want to work with a great team including @tcflab? We are hiring a PhD-level scientist to help orchestrate sequencing of viruses as part of an @CDCgov contract.
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3 Jun 2021
The job will involve working with @publichealthmdc and our clinical colleagues at @UWHealth to examine sequences from people at high risk: persistent infections, reinfections, and those who become infected despite full vaccination.
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3 Jun 2021
The job requires lab work and personnel oversight, but could have partial work-from-home options for the right candidate, especially for those who are strong in computational biology. Apply at jobs.hr.wisc.edu/en-us/job/5… by June 21 for assured consideration. CC: @dho @tcfriedrich

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17 May 2021
New work in collaboration with colleagues at UC-Davis modeling sexual transmission of #Zika virus during early pregnancy. Repeated intravaginal ZIKV challenge was followed by embryonic loss in 2 out of 3 pregnancies. doi.org/10.3389/fimmu.2021.6…

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oconnorlab retweeted
3 Nov 2020
Excited to see that this review with my friends from @TheDohertyInst and @KirbyInstitute on SARS-CoV-2 assays and animal models is out! nature.com/articles/s41577-0…

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4 Oct 2020
Been a while since we posted new animal model data. In collaboration with @BCM_HGSC we are making a new high quality long-read Syrian golden hamster genome. First results are full-length blood transcripts with data here: ncbi.nlm.nih.gov/bioproject/…

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17 Jul 2020
My group with @slo_wis , @tcflab , regulatory support from @UWMadison, saliva guidance from @NathanGrubaugh , support from @WARF_News , @wnprc, and @NIH RADx.
17 Jul 2020
First day testing van-based, fast-turnaround COVID testing by RT-LAMP. Spit in a tube (h/t @NathanGrubaugh), inactivate for 30 minutes, then RT-LAMP to look for color change. Hoping a version of this could enable twice-weekly testing of teachers to keep schools open.
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oconnorlab retweeted
Replying to @KATarinambraun
@KATarinambraun and I have been so fortunate to be in labs that allowed us to shift gears and quickly begin to understand the current pandemic! Excited to see where this all goes! @dho_lab @tcflab
When SARS-CoV-2 began spreading around the world, graduate students Katarina Braun and Gage Moreno made a quick pivot from studying virus evolution and transmission to sequencing local samples of the virus that causes #COVID19: grad.wisc.edu/2020/06/09/cor…
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oconnorlab retweeted
We have updated our WI #SARSCoV2 @nextstrain build to show the 369 genomes that @KATarinambraun and I have sequenced. You can now view it by all of WI, Dane County, or the greater Milwaukee area with higher resolution in the map view ➡️ go.wisc.edu/r7374f @dho_lab @tcflab
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oconnorlab retweeted
Our preliminary analysis of the #Milwaukee #SARSCoV2 / #hCoV19 outbreak is on @LabKey at go.wisc.edu/dp6k0p. The Milwaukee epidemic appears to have few introductions and is largely driven by established chains of local transmission. @KATarinambraun @dho_lab @tcfriedrich

Certain neighborhoods in #Milwaukee have been disproportionately affected by #COVID19 but lacked viral sequencing to understand their outbreak. @KATarinambraun and I were lucky enough to add 93 sequences to the global tree to begin to understand the #MKE outbreak @dho_lab @tcflab
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oconnorlab retweeted
Certain neighborhoods in #Milwaukee have been disproportionately affected by #COVID19 but lacked viral sequencing to understand their outbreak. @KATarinambraun and I were lucky enough to add 93 sequences to the global tree to begin to understand the #MKE outbreak @dho_lab @tcflab
21 Apr 2020
We've just added 93 new genomes from Wisconsin to nextstrain.org/ncov thanks to @KATarinambraun @GageKMoreno @tcflab @dho_lab @GISAID! New seqs in red. 37 of these cluster together in an introduction that seems related to viruses from Asia and California
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oconnorlab retweeted
We continue to sequence Wisconsin viruses – recent viruses are nesting with previously identified clusters, consistent with ongoing community transmission. Physical distancing remains important! @GageKMoreno @tcflab @dho_lab
19 Apr 2020
We've just added 33 new genomes from Wisconsin (red) to nextstrain.org/ncov thanks to @KATarinambraun @GageKMoreno @tcflab @dho_lab @GISAID! Several of these nest directly with previously sampled seqs from WI suggesting community transmission
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oconnorlab retweeted
14 Apr 2020
Replying to @GISAID @HHU_de
The new sequences from WI, USA cluster with previously sampled WI sequences within the North American clusters. Thanks to @KATarinambraun @GageKMoreno @tcflab @dho_lab!
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11 Apr 2020
Thanks to the efforts of David B., we now have a Wisconsin-centric version of the @nextstrain SARS-CoV-2 visualization with data collected by @GageKMoreno and @KATarinambraun openresearch.labkey.com/wiki…

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oconnorlab retweeted
Thanks to everyone who tuned in to hear about the #SARSCoV2 / #COVID19 research happening at AVRL ! If you missed it you can watch it here: uwmadison.box.com/s/zl1warig… @dho_lab

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oconnorlab retweeted
Thanks to @LillyPad @MountSinaiNYC @KATarinambraun @GageKMoreno @tcflab @dho_lab @UNMHSC and @GISAID, we've added 153 genomes from the US (IL, WI, NY, WY)! Many NY genomes (orange, image 1) cluster with those previously sampled there. We also can now see transmission chains in WI
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oconnorlab retweeted
6 Apr 2020
SARS-CoV-2 nonhuman primate data through day 10 now available. Infected animals’ lung lesions seem to be improving. openresearch.labkey.com/proj…?

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