Cancer genetics & biology lab, building and applying new genetic technologies in search of better treatment options for cancer patients
Joined March 2018
- Tweets 1,779
- Following 728
- Followers 2,900
- Likes 2,364
275 Photos and videos
Paper day! This one is a fantastic joint effort from @alynakatti and @AdrianVegaPerez. I tweeted about this >1 year ago when the #preprint dropped, but there was a lot added in review, so... here is iBE - a new inducible #baseediting mouse model! 1/15 go.nature.com/3KzCo2i
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Dow Lab retweeted
May 21
Our paper, co-led with @kevanchu in the @dow_lab, is out today in @Cancer_Cell. We analyzed pre-treatment, on-treatment, and post-progression biopsies from 12 CRC patients treated with KRASi EGFRi.
authors.elsevier.com/c/1n8Il…
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Dow Lab retweeted
9 Aug 2025
Preprint from @dow_lab @WeillCornell using CRISPR base editing screens:
Genetic mechanisms of resistance to targeted KRAS inhibition
biorxiv.org/content/10.1101/…
MAPK reactivation remains the predominant mechanism of resistance to KRASinh. Also identifies a hotspot mutation in CiC.
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Dow Lab retweeted
6 Aug 2025
Excited to share the preprint of my postdoc work @dow_lab and @MSKCancerCenter! Joint work with co–first author @kevanchu
Link: doi.org/10.1101/2025.08.05.6…
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Haven't been on here since the first Tuesday in Nov, but...
...today I was promoted to Professor with tenure at @WeillCornell and wanted to post one last time to thank everyone that has helped our lab over the past 10 years! Science and guitar posts continue @dowlab.bsky.social
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Ok, so unpopular opinion, I guess… I don’t think news entities should ever endorse political candidates.
They can and SHOULD report objectively on all the terrifying stuff coming from DJT. I’d much rather honest reporting than ‘both-sidesing’ and editorial opinions. Inform us!
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Dow Lab retweeted
22 Oct 2024
6 years of work
Over 2 years in review
1 extremely talented graduate student @LeonaNease
Amazing collaborators =
One extremely cool new mechanism that regulates metastasis through modification of the selenocysteine tRNA!
nature.com/articles/s43018-0…
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In no other field do you hire someone for their immense expertise in a very niche field and immediately ask them to change what they do… science is weird.
26 Sep 2024
Can we retire the “How will you distinguish yourself from your postdoc advisor?” question that is typically asked of faculty candidates? I don’t think there is a meaningful answer that would inform a hiring decision one way or the other. Also, it’s silly.
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Dow Lab retweeted
31 Aug 2024
Distinct clinical outcomes & biological features of
specific KRAS mutants in human pancreatic cancer
@Cancer_Cell
doi.org/10.1016/j.ccell.2024…
👉KRASG12R enriched in early stage w/ reduced nodal disease distant recurrence
👉improved OS
🧐 Supports KRAS mutational testing in #PDAC
@myesmo
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Dow Lab retweeted
11 Sep 2024
@dow_lab we're looking forward to your presentation at #AMC25 in the Dominican Republic🇩🇴 next February! Please RT to let your followers know Talk Submission closes next week!
✅Register & Submit: bit.ly/3BbtGoY
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Dow Lab retweeted
29 Aug 2024
Online Now: Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer dlvr.it/TCXth0
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Sharing this for twitterless (X-less?) Rohit Chandwani - a great clinical dive into differences between KRAS G12D/V and G12R mutations. Mirrors clear differences we see in mice. Happy we could contribute a small part to this work. G12R is an odd duck... sciencedirect.com/science/ar…
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Share link for full access (for 50 days): authors.elsevier.com/c/1jgpq…
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Dominican Republic in the “F-off” stage of winter, cool mouse models, some state-of-the-art gene editing… what more could you want?! Come hang on the beach!
18 Jul 2024
📆Save the Date📆
Chairs @KevinHaigisLab & @SageJulien are back to bring us the second instalment of our Animal Models of Cancer conference. #AMC25 will take place from 26 Feb - 01 March 2025 in the Dominican Republic!✅Registration now open: bit.ly/3zK9wBP
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Dow Lab retweeted
18 Jul 2024
📆Save the Date📆
Chairs @KevinHaigisLab & @SageJulien are back to bring us the second instalment of our Animal Models of Cancer conference. #AMC25 will take place from 26 Feb - 01 March 2025 in the Dominican Republic!✅Registration now open: bit.ly/3zK9wBP
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8 months later, but now get to celebrate a safer (single digit) score on the A1! 🍾
TFW you’d love to celebrate an 11% R01 with everyone that worked hard to get it to this point, but you also have zero confidence congress will pass a reasonable budget to @theNCI to get it over the line…
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