Scientist-entrepreneur, drug hunter, rare disease champion, glyco geek 🍭. SF gay 🏳️🌈, )’(, skier ⛷️, traveler ✈️, 🐈-dad. 🇬🇧/🇪🇸/🇩🇪
Joined October 2018
- Tweets 3,192
- Following 932
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100 Photos and videos
Pinned Tweet
17 Mar 2025
We found that 48/80, an MRGPRX2 agonist and commonly used mast cell activator, is toxic in HMC1.2 (human mast cells) and RBL-2H3 (rat basophils). Researchers should use caution and incorporate a viability test when performing assays in these cell lines. research.arcadiascience.com/…
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Justin Donnelly ⌬ retweeted
12 May 2025
All of these companies are Just Another Wannabe Adimab. It doesn't matter that we can make antibodies a week or a month faster. We are in a massively target constrained environment not a binder constrained environment.
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Justin Donnelly ⌬ retweeted
21 Mar 2025
I think this was part of the implicit premise of the first incarnation of Hammer Lab at Mount Sinai, about a dozen of us with math/CS backgrounds ditched tech for biomedicine.
And we got humbled hard: most of what we did flopped & techies don't understand experimental design.
19 Mar 2025
Peter Thiel said that the lack of progress in biology is partially due to a lack of talent.
I think this makes sense. Something about biology's non-technical nature people's inability to tinker w/biology outside of a lab/PhD make the smartest people select other fields.
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Justin Donnelly ⌬ retweeted
21 Mar 2025
But it's a big tell that someone hasn't really ever grappled with the difficulties of actually making a confident discovery from biological messiness to think that the missing ingredient is people who took more signal processing classes or imbibed more essays on tech startups.
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Justin Donnelly ⌬ retweeted
19 Mar 2025
18 Mar 2025
How did we discover that the widely used mast cell activator 48/80 actually kills mast cells rather than selectively activating them? Here's the surprising story 🧵 (1/12)
research.arcadiascience.com/…
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18 Mar 2025
A spinoff of “The Americans” except it’s just the Deel spy at Rippling
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18 Mar 2025
How did we discover that the widely used mast cell activator 48/80 actually kills mast cells rather than selectively activating them? Here's the surprising story 🧵 (1/12)
research.arcadiascience.com/…
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18 Mar 2025
Have you used 48/80? How do you reliably measure mast cell activation? Let’s discuss! Comment on our paper or reply here to join the conversation. Please share this thread if you find this surprising or useful!
research.arcadiascience.com/…
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17 Mar 2025
We found that 48/80, an MRGPRX2 agonist and commonly used mast cell activator, is toxic in HMC1.2 (human mast cells) and RBL-2H3 (rat basophils). Researchers should use caution and incorporate a viability test when performing assays in these cell lines. research.arcadiascience.com/…
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3,246