Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived #ASCO26

Always intrigued me why heparin can be given in renal failure, liver failure without much of a dose adjustment. If its not metabolized by the kidney, liver where does it go? Does it disappear? A 🧵about a unique mechanism

Just a simple fact (except for rare exceptions) - “In thyroid cytology, malignancy exists only if the nucleus says so.”

X’s algorithm needs a reality check. A basic one. Possibly a CT scan. I follow doctors. Almost exclusively. Pathologists, surgeons, physicians.. Still my feed looks like a geopolitical battl3 ground : Epstein files, Olympics highlights, Alysa Leu, Donald Trump, Iran–US war speculation, tariff math I never signed up for. I did not like these posts. I did not engage. I didn't stare Alysa even for 14 seconds. Still algorithm is bombarding her on my feed. I’m on X to increase my pathology knowledge, not to memorize Trump tariff rates like it’s a surprise viva topic. Yes, medical posts don’t generate hype. They won’t trigger dopamine riots. That does not mean academic content deserves algorithmic exile. If I curate my following list like a careful IHC panel, why is my feed behaving like a AFB stain that nobody ordered? Algo engineers, if you’re listening: Relevance > virality. Intent > outrage. Education should have the right to exist in the feed without doing gymnastics. (This is the only place left with intellectuals) People on X, especially in medicine, please tell me I’m not the only one scrolling past wars and politics just to find one decent pathology/medicine thread.

#TooCloseToDiagnose? 🧐 Vascular lesion. A. Pseudomyogenic Hemangioendothelioma B. Epithelioid Hemangioendothelioma C. Epithelioid Hemangioma D. Lobular Capillary Hemangioma #Pathology #Dermatology #Dermatopathology #DermPath

Today's learning #PathX

Did you know “Pautrier microabscess” was mistakenly named after Pautrier? Darier initially described it in MF, but repeated citation of incorrect information by US #dermpath led to this misconception. Don’t trust everything you see in the literature until you verify the facts! 🔬

A super-insightful article on digital pathology. A rare and very well articulated discussion of the human angle of digital transformation. A must read for pathologists! The Mind Behind the Microscope: What Digital Transformation Really Means for Pathologists open.substack.com/pub/beyond… @smlungpathguy @fabiotavora @PathPro

Always good to remember - “An hour of focused microscopy beats three of distracted signout.”

FRIDAY - MARCH 14, 2025 Pi-day (3.14); Albert Einstein’s Birthday (1879) Also born on Pi-Day: Steph Curry, Simone Biles, and Billy Crystal

FRIDAY - MARCH 14, 2025 Mercury Goes into Retrograde This occurs three or four times per year. Just often enough to blame the planet instead of yourself when things go wrong in your life.

Vamos, @RafaelNadal!   As you get ready to graduate from tennis, I’ve got a few things to share before I maybe get emotional.   Let’s start with the obvious: you beat me—a lot. More than I managed to beat you. You challenged me in ways no one else could. On clay, it felt like I was stepping into your backyard, and you made me work harder than I ever thought I could just to hold my ground. You made me reimagine my game—even going so far as to change the size of my racquet head, hoping for any edge.   I’m not a very superstitious person, but you took it to the next level. Your whole process. All those rituals. Assembling your water bottles like toy soldiers in formation, fixing your hair, adjusting your underwear... All of it with the highest intensity. Secretly, I kind of loved the whole thing. Because it was so unique—it was so you.   And you know what, Rafa, you made me enjoy the game even more.    OK, maybe not at first. After the 2004 Australian Open, I achieved the #1 ranking for the first time. I thought I was on top of the world. And I was—until two months later, when you walked on the court in Miami in your red sleeveless shirt, showing off those biceps, and you beat me convincingly. All that buzz I’d been hearing about you—about this amazing young player from Mallorca, a generational talent, probably going to win a major someday—it wasn’t just hype.   We were both at the start of our journey and it’s one we ended up taking together. Twenty years later, Rafa, I have to say: What an incredible run you’ve had. Including 14 French Opens—historic! You made Spain proud... you made the whole tennis world proud.   I keep thinking about the memories we’ve shared. Promoting the sport together. Playing that match on half-grass, half-clay. Breaking the all-time attendance record by playing in front of more than 50,000 fans in Cape Town, South Africa. Always cracking each other up. Wearing each other out on the court and then, sometimes, almost literally having to hold each other up during trophy ceremonies.   I’m still grateful you invited me to Mallorca to help launch the Rafa Nadal Academy in 2016. Actually, I kind of invited myself. I knew you were too polite to insist on me being there, but I didn’t want to miss it. You have always been a role model for kids around the world, and Mirka and I are so glad that our children have all trained at your academies. They had a blast and learned so much—like thousands of other young players. Although I always worried my kids would come home playing tennis as lefties.   And then there was London—the Laver Cup in 2022. My final match. It meant everything to me that you were there by my side—not as my rival but as my doubles partner. Sharing the court with you that night, and sharing those tears, will forever be one of the most special moments of my career.   Rafa, I know you’re focused on the last stretch of your epic career. We will talk when it’s done. For now, I just want to congratulate your family and team, who all played a massive role in your success. And I want you to know that your old friend is always cheering for you, and will be cheering just as loud for everything you do next.   Rafa that!   Best always, your fan, 
 Roger

Its just sad that such influential people are not serious about using their reach to promote better public health related information and awareness.

A Stepwise Approach to Fine Needle Aspiration Cytology of Lymph Nodes 🔬 jpatholtm.org/journal/view.p…

🎨 Papillary thyroid carcinoma nuclear features | Minions edition #pathart @Pathologists @PathElective #Pathresidents #Pathology #pathX #PathTwitter #pathology

Hydatidiform mole, partial or complete? 🔬lmpimg.med.utoronto.ca/LMP97… #GYNPath #PathTwitter #Pathology #Placenta

Thyroidectomy from 70 yo F What’s going on? How would you stage this? #PathX #COTW

Toluidine-stained cross section of a sural nerve. What is the structure indicated by the red arrow? (I'll go out for a nice country drive in my RENAULT sports car while you're thinking about it.) #pathology #neuropath #PathTwitter

As a physician I'm sure you've seen patients with ITP! Let's start by calling it IMMUNE thrombocytopenia instead of IDIOPATHIC thrombocytopenia. The P stood for Purpura in the past. Not anymore! T= Thrombocytopenia = <100,000 platelets #MedTwitter 1/20

Weedon Lecture in 6 h. Dedicated to both Dr David Weedon & my beloved mentor Dr McKee, legends of #Dermpath 20 year obsession & CLIN-H&E-IHC in DX of KA & FSCC-KAL. Please 🙏❤️🙏 re-tweet my cases & share with colleagues to make sure KA is retained as dx-entity