Skeptic, Pathologist
Joined March 2016
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28 Jul 2024
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Introducing a new thread: super basic lung pathology for PGY1s, with arrows. If you are a PGY1, leave a comment and I will tag you in a future post.
A hamartoma is a disorganized mix of overgrown normal tissues (in their normal location) that creates a mass. Good news: they are benign!
#pathology #pulmpath #tweetorial #pathtweetorial #sblppgy1
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Too close to Dx?
Teen hard palate lesion.
Yes... Location is odd... this is 10X...
2X or 4x is your best friend.
#TooCloseToDiagnose #ENTpath #PediPath
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Jun 11
"One breaks the fence. The other finds the bloodstream. Both spell trouble." 🔬⚡
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#path_clicks #pathology #peace #surgicalpathology #lablife
⚡ Pathologist's red flag?
instagram.com/p/DZccGboCT8T/…
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28 May 2020
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Jun 10
⚡Tumor was removed from a 31 y/o female who presented with abdominal pain.
✨CT scan demonstrated a well-defined, hypodense mildly enhancing lesion behind the lower pole of the left lobe of the thyroid.
🍁Diagnosis ⁉️
#path_clicks #pathology #pattern #passion #lifestyle
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Jun 9
Brain mass in a male in his early 60s, who presented with visual impairment and headache.
MRI shows a mass in the sellar region with suprasellar extension. The mass is well circumscribed with a capsule (the first image shows otherwise).
Looks like ependymoma (papillary), but the site is odd. Kindly share your thoughts @CraigHorbinski @Kenneth_Aldape
@bitar_mireille @FRodriguezNP @mlage
#Neuropath #CNSPath
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CMV cervicitis is an uncommon finding and may be underrecognized. Most patients are immunocompetent and asymptomatic. Rx is often not required, although management depends on the clinical context. CMV is a TORCH infection and may have implications during pregnancy. #pathtwitter
Uncommon find in a cervical biopsy... I spy... 🕵️♀️👀
#pathbugs #gynpath #gynepath #pathtwitter #pathx
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#pfotd Only nuclear staining for TTF-1 should be considered positive
Jun 7
TTF-1 pitfall: while we rely on nuclear staining for tumors of lung/thyroid origin, hepatocytes can show granular cytoplasmic TTF-1 staining (clone-dependent). Always look for clean nuclear staining and correlate with markers like HepPar1, Arginase, and clinical context.#CytoPath
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#pathbugs #crittersontwitter #PathTweetAward
#pfotd Nuclear inclusion cytoplasmic inclusions big cell = virtually pathognomonic of CMV
Uncommon find in a cervical biopsy... I spy... 🕵️♀️👀
#pathbugs #gynpath #gynepath #pathtwitter #pathx
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Sanjay Mukhopadhyay retweeted
TGIF: Teen with history of travel to 🇩🇴 a week prior to conjunctiva lesions (0.5 cm)
Seen this some 25 years ago.
@ParasiteGal @leon_metlay @DrJuhlin @SabBergeron @Histopatolomon @yro854
#pathtwitter #PathBugs #CrittersonTwitter #ENTPath #TGIF
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100% agree
History is one of the best special stains. Calling your colleagues like radiologist and clinician is another .
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Maybe some day we will all realize what a giant shamwow the IgG4 saga was...
Jun 6
Low-grade B-cell lymphomas may present with prominent reactive inflammatory infiltrates or coexist with autoimmune disorders
⚠️ Increased IgG4:IgG ratio? Stop and think before diagnosing IgG4-related disease. Always exclude an associated lymphoproliferative disorder
What is the cause of abundant IgG4 in lymphomas?Possible explanations...
1. Non-neoplastic IgG4 cells within the tumor microenviroment
2. Monoclonal IgG4 production by lymphoma
3. Lymphoma can coexist with IgG4-related disease and other autoimmune disease
Dr. Herrera Hernandez #USCAP2026 #pathology #PathX #PathTwitter
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Sanjay Mukhopadhyay retweeted
This is exactly why I keep a personal microscope at home since early residency 😅 just to experience this side of microscopy for fun. It’s amazing how much beauty and complexity is hidden in everyday things around us. ✨
I made a smear from a potato and examined it unstained and then under polarized light
Starch granules in potato contain amylopectin = Maltese cross birefringence
#pfotd @yro854 @tbkwatkins @kriyer68
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This is true. However, there are also tumors that are positive for TTF-1 or p40 but are not lung carcinoma. The issue of lung cancer vs. non-lung is not as straightforward as it first appears and no IHC panel can prevent errors 100% of the time while still preserving tissue for molecular testing
Jun 5
***Lepidic pattern is not limited to primary lung tumors***
- Female patient with history of breast cancer now with lung lesion (pic 1 and 2): Mesothelioma, epithelioid type
- Melanoma (pic 3)
- Cholangiocarcinoma (pic 3)
Practical lession: Lung tumors that looks like carcinoma but negative for TTF-1 and p40, add Claudin 4 and WT-1 to exclude the possibility of mesothelioma
Dr. Sauter #USCAP2026 #pathology #PathX #PathTwitter
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Part 2. We had a pap smear but decide to use it, after evaluating it, for inmuno (just to test an antibody we rarely use in cytopathology). Colleague's case
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I made a smear from a potato and examined it unstained and then under polarized light
Starch granules in potato contain amylopectin = Maltese cross birefringence
#pfotd @yro854 @tbkwatkins @kriyer68
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Sanjay Mukhopadhyay retweeted
History is being made right now, and I’m proud to be part of it. This is week 1 of Digital Pathology Go Live at my home institution Moffitt Cancer Center. @MoffittNews @ml4onco @MoffittGR @dpatweet @Pathologists @FLPathologists @CAPA_comm @USFpathology
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Sanjay Mukhopadhyay retweeted
Read this interesting entity in 🫁 EWSR::CREM Fusion! Fresh out of press in Diagnostic Cytopathology ! Thankful for the collaborative work on this with @smlungpathguy @priya_upa cc: @aakasharmand @PoonamVohra3 @GokozanMD @PapSociety
onlinelibrary.wiley.com/doi/…
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Jun 5
Sanjay, I love this idea. So far all #pfotd posts are from you. Are we invited to use this hashtag?
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CC390. FNA of a malar nodule (<1 cm) in an old man. Two more images below #cytopath @kriyer68 @kis_lorand @DrMarkOng @edusqo @MAHoureih @AnupamaArya12 @premcharles
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