Five years ago we sketched out the designs for our first epigenome editors. Proud to see those sketches move into the clinic. You can read more about the technology underpinning our epi-editors in this preprint we recently presented at ASGCT: biorxiv.org/content/10.64898…

Transforming traditional views laid by “CNS immune privilege,” our research uncovers the brain’s purposeful presentation of self – that is the brain engages with the immune system through “guardian” peptides to ensure immune tolerance. @jonykipnis nature.com/articles/s41586-0…

Check out our new preprint showing our ability to use epigenetic age measured from blood to predict AD progression & cortical atrophy! ⁦@dwsir⁩ ⁦@UCSFimaging⁩ ⁦@UCSFmac⁩ ⁦@nanosanta⁩ ⁦@AgustinMIbanez⁩ ⁦⁦@Cornell⁩ researchsquare.com/article/r…

New paper out📢! Toxic effects of IFN-I in humans has been suggested in patients with rare monogenic autoinflammatory diseases (SAVI, CANDLE, AGS) where IFN-I are elevated. In the absence of specific inhibitors, their causal role has been difficult to prove. We now report benefit of specific anti-IFNAR1 (#Anifrolumab) in 5 patients verifying the causal role of IFN-I in these diseases: rdcu.be/dXWPw

Holy moly. In some individuals, p-tau181 is >300-fold higher in cervical lymph nodes than plasma. Seems like this could be a reasonable location to predict exposure of T cells to tau-derived peptides.

Having worked on mechanisms of unconventional synuclein secretion, this paper looks awesome and the data compelling. However--not having read the full text--I am left with the following dispiriting impression: - Arc function = bad outcome - lack of Arc function = bad outcome

For the first time in 114 years, biologists from the Oregon Department of Fish and Wildlife have observed a fall-run Chinook salmon returning to spawn in the Klamath Basin in Oregon, after dam removal.

Circulatory proteins shape microglia state and boost phagocytosis!!!!! biorxiv.org/content/10.1101/…

Continuing with #crossreactivity and #TCR Another paper that I #love We simply #cant #afford to have "#holes" in the #repertoire. Virus-Specific CD4 Memory-Phenotype T Cells Are Abundant in Unexposed... sciencedirect.com/science/ar…

I enjoyed leading this effort to highlight recent advances in understanding interferon pathway dysregulation in neurodegenerative disease, including new work by our group. We also discuss cognitive and behavioral changes related to IFN and its relevance in psychiatric disease.

Learn about the intriguing connections between neurodegenerative & neuropsychiatric diseases 🪢 via alterations in interferon signaling! 🧠 @dwsir @AlexisOddi @C_WSolsberg @UCSFmac @DataTecnica @FTDcwow @GBHI_Fellows #WomenInSTEM frontiersin.org/journals/psy…

I learned something new today!

HHMI Investigator Zhijian "James" Chen of @UTSWMedCenter has been named the 2024 Albert Lasker Basic Medical Research Award winner for his discovery of the DNA-sensing cGAS enzyme, which triggers immune & inflammatory responses. 👏 👉 hhmi.news/47wJnn2

A neurologist in Colombia, he worked with the world’s largest extended family with Alzheimer’s and helped fuel research to prevent or delay dementia symptoms. nyti.ms/3MGKozi

Incredibly excited to share our latest work exploring the antigen specificity of clonally-expanded CSF-enriched CD8 T cells in MS  #multiplesclerosis #Tcells #EBV 🧵1/ biorxiv.org/content/10.1101/…

Immortal quote from the amazing geneticist Gerry Fink… “Just because it’s in Nature… … doesn’t necessarily mean it’s wrong!”

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.1101/…

🚀 Excited for @YokoyamaLabUCSF to serve as Editor-in-Chief for @Nature_NPJ! #DementiaResearch #OpenAccess #cwowleads