🔗“Absolute and relative risks of mental disorders in families: a Danish register-based study”
👉 thelancet.com/journals/lanps…
📌Key findings:
• Mental disorders are highly heritable – but most cases have no family history
People with affected 1st/2nd-degree relatives have higher risk
• Yet most cases are non-familial:
▫ 89% schizophrenia
▫ 60% depression
▫ 96% schizoaffective
1/n Familial aggregation studies of diseases rely on familial information linked with health records. We investigated the completeness of familial links in the Danish Civil Registration System and described the future Danish Multi-Generation Register
doi.org/10.1177/140349482211…
Congratulations, Emil – beautiful presentation, impressive work!
@EmilP94637497 did an excellent job defending his PhD entitled: ”Leveraging family history and age-of-onset to boost GWAS power and disorder prediction”. Great discussion by the opponents @zkutalik, @michelnivard
GWAS of ADHD by @DemontisDitte, @AndersBorglum and team identified 27 genome-wide significant loci, show that 84–98% of ADHD-influencing variants are shared with other psychiatric disorders, and much more.
nature.com/articles/s41588-0…
Better late than never. Happy and relieved to share a final published version of one of my PhD projects in which we uncovered a fascinating genetic link between language ability, psychiatric risk and creativity. 🧵
nature.com/articles/s41598-0…
Individuals with mental disorders lose 10·5 years of working life. Those with schizophrenia, mood, neurotic, eating disorders lose 18.9, 10.3 and 6.7 yrs
We would like to share with you our recently published article “Identification of shared and differentiating genetic risk for autism spectrum disorder, attention deficit hyperactivity disorder, and case subgroups.” rdcu.be/cWmMA… Details below.