ceo @1000cures, ceo @PerlaraPBC (w16 @ycombinator), founder @epalrestat, founder @endrarediseases, founder @smer28rapa
Joined January 2011
- Tweets 62,301
- Following 1,830
- Followers 19,118
- Likes 95,942
1,391 Photos and videos
Pinned Tweet
Apr 17
I've met so many entrepreneurial rare disease parents over the years that I’ve lost count.
They have moved or are moving medical mountains to save their kids and others like them.
But rare parent founders get no love from institutional players.
Those days are done.
Science, talent and compute are no longer limiting.
Priority Review Voucher alpha makes the economics work.
The missing spark is access to cure capital.
That's why I’m incredibly pumped to relaunch @1000cures with my cofounder @ryan_1000cures!
Ryan and I teamed up to create a “YC for Rare” that unites our biotech houses with complementary expertises, experiences and networks.
1000 Cures is an accelerator for lean startups led by parents on mission to cure pediatric rare diseases.
We ride at dawn.
Let’s go!
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Ethan Perlstein 1-to-N retweeted
Jun 11
Okay, folks: The big El Niño update is now out on Weather West! This sure looks like it's going to be a dramatic year from a global climate perspective, and there are major implications for extreme events (across California, the U.S. West, & well beyond). weatherwest.com/archives/438…
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Ethan Perlstein 1-to-N retweeted
Jun 11
most people in biotech don't even know the PRV exists, but the data are there for anyone who's curious 📊👀
at the current clearing price of ~$200M, it now pays to invest in rare disease drug development
the demand for PRVs is going up because pharma is hungry for blockbusters
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Jun 11
most people in biotech don't even know the PRV exists, but the data are there for anyone who's curious 📊👀
at the current clearing price of ~$200M, it now pays to invest in rare disease drug development
the demand for PRVs is going up because pharma is hungry for blockbusters
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Ethan Perlstein 1-to-N retweeted
Jun 10
Why aren’t more people are talking about the Priority Review Voucher (PRV) program?
Folks act like it’s some kind of state secret.
It’s just a market exclusivity fee on global blockbusters that is paid by Big Pharma.
More accurately, it’s a consensual and democraticizing wealth transfer from Big Pharma to Baby Biotech aka FAMCOs.
One easy way to restore people’s trust in Pharma is for there to be more FAMCOs, or family-founded biotech companies, in the ecosystem.
So why aren’t we shouting PRV from the rooftops?
Are folks worried about an oversupply of PRVs that would crash the price?
@1000cures is taking the other side of that bet.
We believe that more PRVs will stimulate innovation by incentivizing competition for market share of global blockbuster medicines.
Big Pharma is vigorously competing to score approval on the next Ozempic and will happily fork over $200M for a chance at billions in sales.
It’s like buying a dollar for a dime.
And with longevity medicines on the horizon, the demand for market exclusivity on global blockbuster medicines will keep increasing.
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TradBio is crashing out
USA can’t compete with China
Meanwhile the most capital efficient operators in biotech are flying under the radar right here at home
I’m talking about rare disease parents going founder mode to cure their kids
They are the face of precision medicine
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Ethan Perlstein 1-to-N retweeted
Would be an absolute game changer if the new FDA commissioner came from the rare disease world — someone like John Crowley or Emil Kakkis
As the FDA tries to clarify its intent for former FDA Commissioner Marty Makary’s plausible mechanism framework for bespoke therapies, experts emphasize expanding its scope to encompass rare diseases that affect more than just one or a few individuals.
hubs.li/Q04ks_LQ0
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order your Wayho now
Jun 8
Escorts are charging as much as $6k per hour thanks to Silicon Valley's AI boom trib.al/EY38Nuz
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will there be any Chinese sponsors?
Jun 5
Also, on Monday I’m hoping to unveil a few details about BiotechTV’s first ever event. It’s going go be a summit in Kendall Square this summer with the theme of turning around the narrative on science and biotech in the United States and beyond. Stay tuned.
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The biotech industry is split into two camps:
globalist TradBio vs America-first TechBio
Jun 3
House bill aims to crack down on China #biotech deals biopharmadive.com/news/binsa… by Kristin Jensen $XBI $IBB
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Ethan Perlstein 1-to-N retweeted
Jun 1
after a weekend in Puerto Rico, my idea is a pill that protects your whole body from the sun
LAST CHANCE TO SIGN UP!
May 15
@CompoundVC is having an Idea Factory event in NYC!
We want *YOU* to come and share your most futuristic biotech idea on June 2 6-8PM.
We've been floored by some of the ideas we've discussed previously:
> Sequencing of chemical reactions instead of DNA
> Self-evolving cancer vaccines
> Image activated directed evolution
> Dementia vaccines
> Pooled drug screens in humans
> Coffee that doesn't stain teeth
And we want to discuss yours too! Signup below:
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Proud investor!
Opening new R&D site in Boston as folks move to China. Continue to believe US is best place in world for novel platform innovation, and UK for discovery biology.
aerska.com/news/aerska-expan…
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Looking forward to this event tonite!
May 30
I'm having a get-together at Reign on June 1st in NYC.
DM/leave a comment/go RSVP at the Luma if you want to come.
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Ethan Perlstein 1-to-N retweeted
Jun 1
Love @openAI and @sama leaning in on robotics!! We need to bring AI models into the world of atoms where most of the important things for humanity lives. I talked about it on @tbpn with @ginkgo's lab robots and how AI lab robots will enable everyone to be a scientist someday. Robots behind me are what GPT-5 ran for our project with OpenAI earlier this year! LFG
May 31
OpenAI Robotics is hiring, looking for exceptional full-stack hardware, ops, systems, and ML engineers to help us program and manufacture robots that are useful for society.
AI should be able to help people in the physical world. In the short term, we are focused on robots to support skilled workers to build our future infrastructure; in the long term, we imagine everyone having a personal robot doing anything they need.
Our world simulation research program, led by Aditya Ramesh (@model_mechanic), has evolved over the past year into OpenAI Robotics. Progress is rapid, and based on a foundation of co-design between robotics hardware and ML research.
If you love working hands-on across the robotics stack and want to build the future, please consider joining us. Send an email with your background and evidence of exceptional accomplishment to: robotics-recruiting@openai.com
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Ethan Perlstein 1-to-N retweeted
Jun 1
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💯on all counts
I’d just add one note:
The next FDA Commissioner must fight to end rare genetic diseases
May 30
1/ US biotech is in crisis, right before AI should be saving millions.
China is stealing away our industry and has surpassed the US in blockbuster pharma deals.
The next FDA Commissioner must be a fighter, and have a plan to overhaul the agency, beat China, and unleash cures.
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Ethan Perlstein 1-to-N retweeted
May 28
you go to your 25th college reunion to see who’s alive and still hot, right?
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