Tumor cells metabolically resist immune-checkpoint therapy by macrophage efferocytosis-mediated fatty acid recycling dlvr.it/TT3Vld

A new tool powered by artificial intelligence has been used by surgeons in the UK for the first time. The Eureka system colour codes parts of the body to help doctors protect or dissect different parts of the anatomy during surgery. Full story ⬇️ trib.al/JihMpYW

Now published open access online first “Unintended prolonged and permanent stoma following restorative rectal cancer surgery with defunctioning loop ileostomy: A systematic review and meta‐analysis” @UCDMedicine congrats Paolo & colleagues! Access via dx.doi.org/10.1111/codi.7048…

This month's Resident Corner focuses on Shared Decision-Making in Locally Advanced Rectal Cancer. Read now in #DCRJournal: bit.ly/3QNTTSA

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Circulating Tumor DNA for Minimal Residual Disease in Colon Cancer: Ready for Prime Time? Read the full article. bit.ly/3R6vkAl #crcsm

New ESPEN-Endorsed Recommendation Published We are pleased to share a new open access ESPEN-endorsed recommendation published in Clinical Nutrition: “Sarcopenic obesity: Call to action and nutritional agenda from the international clinical nutrition community” Sarcopenic obesity, defined as obesity with low skeletal muscle function and mass, is increasingly recognized as an important clinical nutrition priority. This international statement highlights the need for coordinated action in research, education and clinical practice, with a strong focus on diagnosis, prevention, nutritional care and multimodal treatment approaches. The publication also emphasizes the key role of nutrition and exercise in reducing the burden of sarcopenic obesity and improving outcomes for people living with obesity worldwide. Read the full open access publication here: clinicalnutritionjournal.com…

My daughter was diagnosed with bowel cancer at 17. Four months later she was dead telegraph.co.uk/health-fitne…

Online Now: Cancer cachexia: A tumor-driven disorder of whole-body homeostasis dlvr.it/TS8ngh

In the UK, an estimated 1 in 10 women live with endometriosis. This is where tissue similar to the lining of the womb grows in other parts of the body, such as the ovaries, and lining of the pelvis. Symptoms include severe pain, fatigue, infertility and gastrointestinal issues. Diagnosing endometriosis can be challenging as other conditions can cause these symptoms. Read about how research we are supporting is helping improve diagnosis and treatments for endometriosis: bepartofresearch.nihr.ac.uk/…

Four million physician hours are spent on mandatory modules each year. They represent not just clinical time lost but “evenings reclaimed and cognitive load reduced.” Redundant training and low-value modules should be a thing of the past. jamanetwork.com/journals/jam…

Among adults with multiorgan metastatic #ColorectalCancer, adding local debulking to chemotherapy did not improve survival and increased serious adverse events. ja.ma/3QjR3EI

#Obesity is associated with higher risk for 12 #cancer types and accounts for approximately 10% of annual new cancer cases in the US. 📄 This Review summarizes the primary biological pathways connecting obesity and cancer development. ja.ma/3QmlV7C

A good refresher on the subject

Among patients with severe blunt splenic injury and multiple trauma, nonoperative management with angioembolization or observation reduced mortality, complications, and hospital stay compared with splenectomy. ja.ma/4sEX2kN

Intratumoral lymphatics: When less is more dlvr.it/TS56zs

💬 Viewpoint: Mandatory annual training modules consume millions of physician‑hours each year, yet their largely passive formats may offer limited educational value while contributing to administrative burden and clinician burnout. ja.ma/4vvyvBm

Laparoscopic adhesiolysis for #SmallBowelObstruction was not superior to open surgery for long-term recurrence, incisional hernia incidence, or quality of life at 5-year follow-up, confirming both as viable options. ja.ma/3Qnrpi7

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up† - Annals of Oncology annalsofoncology.org/article…

Cool to make the cover of this month’s @LancetGastroHep congrats Éanna Ryan et al! @UCDMedicine @UCD_Research @ucddublin access the paper via thelancet.com/journals/langa…