Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut

Imbalances in the mammalian gut are associated with acute and chronic conditions, and using engineered probiotic strains to deliver synthetic constructs to treat them is a promising strategy....

pubs.acs.org

David Edgell @megatev

13 Aug 2025

New paper 📢. What happens when @gary_wfoo genetically entangles a thermally-regulated meganuclease and colE9 immunity protein? Ultra-stable biocontainment in the mammalian gut!! biorxiv.org/content/10.1101/…

443

Olivier Borkowski

Gary Foo retweeted

Olivier Borkowski @O_Borkowski

8 Sep 2025

Genetic Entanglement Enables Ultrastable Biocontainment in the Mammalian Gut pubs.acs.org/doi/10.1021/acs…

978

David Edgell

Gary Foo retweeted

David Edgell @megatev

14 Aug 2025

Paper 🚨📢! Adenine methylation in PAM sequence regulates Staph aureus Cas9 activity in bacteria. biorxiv.org/content/10.1101/…. Superstar collab between #DaltonHam @nortnlentivirus

PAM adenine methylation and flanking sequence regulate SaCas9 activity in bacteria

Cas9 nucleases are the effectors of the class 2 type II CRISPR system in bacteria and function to restrict invading DNA. They can also be used with single guide RNAs (sgRNAs) as antimicrobials and...

biorxiv.org

382

David Edgell

Gary Foo retweeted

David Edgell @megatev

13 Aug 2025

Genetic entanglement enables ultra-stable biocontainment in the mammalian gut

Imbalances in the mammalian gut are associated with acute and chronic conditions, and using engineered probiotic strains to deliver synthetic constructs to treat them is a promising strategy....

biorxiv.org

1,595