GPCRdb contains data, diagrams and web tools for G protein-coupled receptors (GPCRs).
Joined April 2014
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- Followers 1,151
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Database developer staff scientist positions (5-year) open now (employment.ku.dk/staff/?show…). Join our great team to build tomorrow’s online research data/tool infrastructure enabling science and drug design for GPCR drug targets and their signaling proteins. #programming
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New online data and tool resources for basic research and #drugdesign on #GPCR and signaling proteins funded by Infrastructure grant from @novonordiskfond. Keep an eye out for GPCRdb, GproteinDb, ArrestinDb and BiasedSignalingAtlas and new databases. #DataScience @DrGPCR
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The new gpcrdb.org 2023 March update is online! Check out all the new data and features #GPCR
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Biased Signaling Atlas preprint is out doi.org/10.21203/rs.3.rs-215… describing the birth of a new database dedicated to biased signaling, may let #GPCR drugs favor therapeutic over adverse signal pathways.
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GPCRdb 2023 with state-specific structure models using AlphaFold2 and new ligand resources is now online (doi.org/10.1093/nar/gkac1013). Thanks to the team, #GPCR community, @NAR_Open, @lundbeckfonden and @novonordiskfond.
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New publication in eLife shows how different datasets were integrated in the common coupling map in GproteinDb. dx.doi.org/10.7554/eLife.741… and gproteindb.org/signprot/coup…
19 Apr 2022
Proud to share our article “Common coupling map advances #GPCR - G protein selectivity” as a final pdf in eLife. dx.doi.org/10.7554/eLife.741… It integrates datasets from the @Michel_Bouvier and Asuka Inoue labs, and the @GuidetoPHARM database to arrive at several new insights.
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The new Biased Signaling resource in GPCRdb will act as a hub for reporting biased ligands while supporting these community guidelines.
28 Mar 2022
Finally, much-needed community guidelines for #GPCR ligand bias! Can better experiment design and reporting clarify complex pharmacology towards #drugdiscovery with fewer adverse effects? doi.org/10.1111/bph.15811
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Open position for a research assistant or postdoc in bioinformatics / database development.
employment.ku.dk/faculty/?sh…
#GPCR @pharmacogenomics @DatabaseDev
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GPCRdb retweeted
8 Dec 2021
Big congratulations to Albert Kooistra, lead developer of GPCRdb, for receiving the Frank Blaney Award from the Molecular Graphics and Modelling Society! lnkd.in/e_iQ_gQY #GPCR lnkd.in/eWPhptnA
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GPCRdb structure analysis resource out in NSMB.
10 Nov 2021
Proud sharing cover page and two back-to-back articles in @NatureSMB describing a new structure analysis platform revealing #gpcr activation mechanisms across classes and macro/microscales. dx.doi.org/10.1038/s41594-02… and dx.doi.org/10.1038/s41594-02…
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Proud to present the publication of GproteinDb dedicated to G protein research and sister database of GPCRdb (). Thanks to the team, #GPCR community, @lundbeckfonden, @novonordiskfond, and @DFF_raad. lnkd.in/eAbmv3YV
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Check out the new GPCRdb resources in our webinar on June 24th at @DrGPCR lnkd.in/e9h2Fjc. Thanks to @yaminaberchiche. #gpcr
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Temporary free access here authors.elsevier.com/c/1d8g~… :)
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Excited to share our new review, Structural dynamics bridge the gap between the genetic and functional levels of GPCRs
doi.org/10.1016/j.sbi.2021.0… .
Great work @David_Gloriam @JanaSelent @MarionaTf @t00mek88 !
@ErnestNetwork @GPCR_ECC @j0kaso @gpcrdb @DisGeNET
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GPCRdb retweeted
26 May 2021
In two pre-prints we present a new structure analysis platform uncovering #gpcr activation mechanisms across classes and macro/microscales. & lnkd.in/ei8xEnu #structures lnkd.in/ekB4v7W
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Head of GPCRdb, David Gloriam shares his story as a #gpcr scientist and inspiring young researchers in a podcast @DrGPCR DrGPCR.com/Podcast. Thanks to @YaminaBerchiche and #drgpcr
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The GPCRdb 2021 version integrating sequence, structure and function is now online in Nucleic Acids Research (doi.org/10.1093/nar/gkaa1080). Thanks to the team, #GPCR community, @lundbeckfonden and @novonordiskfond.
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Class D1 nomenclature and alignments now in GPCRdb.
2 Dec 2020
Nature article rdcu.be/cbBRD of class D #GPCR structure, Ste2 dimer coupled to two G proteins from Chris Tate lab @MRC_LMB and adding @GPCRdb resources. Thanks to @VaidehiLab, @DFF_raad, @lundbeckfonden & @novonordiskfond. lnkd.in/eP23JG lnkd.in/ew9_qnD
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Nature article doi.org/10.1038/s41586-020-2… showing #GPCR isoform signalling bias, and a GPCRdb resource gpcrdb.org/protein/isoforms. Another landmark study from @m_madan_babu group and great teamwork by Marti-Solano et al. Thanks to @Lundbeckfonden and @novonordiskfond
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