In a study published in ACS Central Science, the Bryan Dickinson Group at the University of Chicago Department of Chemistry of Chicago and the Jeff Martell Lab at the University of Wisconsin-Madison have developed a "lock and key" system for high-precision cellular mapping. By pairing a stable chemical mask with a custom-evolved enzyme that is 200 times more active than its natural counterpart, the team has significantly reduced the "background noise" typical of proximity labeling. This system powers BAP-seq, a method that identifies and sequences RNA exactly where it resides in human cells without the "leakiness" of previous techniques. By providing a high-fidelity map of molecular activity, this collaborative technology offers a more accurate tool for investigating disease mechanisms and developing targeted therapeutics. Link---> shorturl.at/gvqx5 #ACSCentralScience #ChemicalBiology #UChicago #CellularMapping #UWMadison #MolecularImaging #BAPseq #DickinsonGroup #Science #UChiChemistry

Our latest study on the first integrated structural proteomics (LiP-MS FAIMS-DIA) and N-glycoproteomics analysis of paired serum and CSF samples across AD stages is published in #ACSCentralScience 🥳🥳 Congrats to @Happysmilexyz68 and all co-authors🎊🎊 pubs.acs.org/doi/10.1021/acs…

✨ Our first reactions article in @ACSCentralScience with #CyrilGoudet is officially out! 🎉 pubs.acs.org/doi/10.1021/acs… Don’t miss the chance to dive into the fantastic work of #AmadeuLlebaria #Xavier Rovira and #VenkateshKrishnan – great read for the winter break! ❄️ 💛 #ProfLife

Excited to share our new ☀️Collection☀️ in #ACSCentralScience, highlighting the central role of #enantioselectivity in natural product synthesis & drug discovery! ⏩pubs.acs.org/page/acscii/vi/… You can read our editorial here: ⏩pubs.acs.org/doi/10.1021/acs… #Enantioselective #Catalysis

Our collaborative work "The #Martini3 #Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior" is now published in #ACSCentralScience! 🎉 📄 Read: pubs.acs.org/doi/10.1021/acs… 💾 GitHub: github.com/Martini-Force-Fie… #MolecularDynamics #Biophysics #Simulations #Lipids

Check out this new direct #CHfunctionalization method for fused azines at #ACScentralscience : broad, metal-free and proceeding with exclusive and predictable #regiocontrol! Executed in #parallelmode for its immediate application to #drugdiscovery! 💊 pubs.acs.org/doi/10.1021/acs…

kksand.com/post/featured-at-… My research is featured at#ACSCentralScience. Thanks @CarolynMWilke and ACS for the opportunity to showcase how minerals, nano-level dynamics and geochemistry can influence evolution and taphonomy of @SedimentaryDNA #sedDNA @VILLUMscience @Carlsbergfondet

🔬 Exciting News! Our collaborative scientific paper on Chemical Reactivity is now out! 🎉 Title: “Dataset Design for Building Models of Chemical Reactivity” 📄 Read more: pubs.acs.org/doi/10.1021/acs… #ChemistryCollab #ScienceTogether #NSF #Innovation #Compchem #ACSCentralScience

ARTÍCULO REFERENCIA (acceso abierto) Thermal Synthesis of Carbamic Acid and Its Dimer in Interstellar Ices: A Reservoir of Interstellar Amino Acids pubs.acs.org/doi/10.1021/acs… vía #ACSCentralScience

Absolute Affinities from Quantitative Shotgun Glycomics Using Concentration-Independent (COIN) Native Mass Spectrometry #ACSCentralScience pubs.acs.org/doi/10.1021/acs…

Resistenzen mit einem Cisplatin-Prodrug überwinden: Miami – In-vivo-Experimente am Tiermodell deuten darauf hin, dass Cisplatin-Resistenzen bei Prostatakrebs erfolgreich überwunden werden könnten. Dazu entwickelten amerikanische… #ACSCentralScience dlvr.it/SsWH02

When you are caught without your baby changing pad and have to resort to your #acscentralscience T-shirt that @CarolynBertozzi gave you years ago 😂 (in no way a reflection of my high esteem for this fabulous journal)

Really excited to share our work in #AcsCentralScience on the recognition of bacterial WTAs by mAbs. @CDicarluccio @MolinaroTony @AlbaSilipo Nice collaboration with @markvanraaij @N_van_sorge & Jeroen Codee pubs.acs.org/doi/10.1021/acs…

High-fat diet linked to nitric oxide levels, cancer development @ACSCentSci #ACSCentralScience #nitricoxide #diet #High-fatdiet #cancer #cancerdevelopment #cancerresearch #tumormicroenvironment #tumor #tumorcells #foods medicaldialogues.in/oncology…

Nice article regarding guidelines how to run glycosylation from our lab! #acscentralscience pubs.acs.org/doi/10.1021/acs…

La revista @ACSCentralScience, órgano de la Sociedad #Estadounidense de Química publicó un artículo d los investigadores cubanos que han desarrollado los candidatos vacunales contra la #COVID19, #Soberana01 y #Soberana02. #CubaPorLaVida @BioCubaFarma @MINCEX_CUBA @Granma_Digital

ACSCentralScience (@ACSPublications) da a conocer revisión científica sobre relevancia de las vacunas basadas en RBD: una posición colaborativa para apoyar las vacunas candidatas cubanas que despiertan creciente admiración en comunidad científica internacional #CubaSalvaVidas

doi.org/10.1021/acscentsci.1…. Our review published in ACSCentralScience about the relevances of RBD-based vaccines: a colaborative possition for supporting the cuban candidate vaccines. @FinlayInstituto @centro_cim @SintesisLab @UdeLaHabana @BencomoVerez @BioCubaFarma @EdMartBCF

Our paper on PhoX, an IMAC enrichable crosslinking reagent is out in #ACSCentralScience! bit.ly/9b00416 #XLMS #CXMS #StructuralProteomics

#ACSCentralScience #BartonGroup #MagnetoElectrochemistry pubs.acs.org/doi/abs/10.1021…