In a study published in ACS Central Science, the Bryan Dickinson Group at the University of Chicago Department of Chemistry of Chicago and the Jeff Martell Lab at the University of Wisconsin-Madison have developed a "lock and key" system for high-precision cellular mapping. By pairing a stable chemical mask with a custom-evolved enzyme that is 200 times more active than its natural counterpart, the team has significantly reduced the "background noise" typical of proximity labeling. This system powers BAP-seq, a method that identifies and sequences RNA exactly where it resides in human cells without the "leakiness" of previous techniques. By providing a high-fidelity map of molecular activity, this collaborative technology offers a more accurate tool for investigating disease mechanisms and developing targeted therapeutics. Link---> shorturl.at/gvqx5 #ACSCentralScience #ChemicalBiology #UChicago #CellularMapping #UWMadison #MolecularImaging #BAPseq #DickinsonGroup #Science #UChiChemistry

Mujer mata a su bebé porque no la dejaba jugar FarmVille en Facebook http://bit.ly/bapSEQ