CONGRESS |
#EHA2026 | PRESENTATION
Enrique Ocio presents final results from the phase I DREAMM-9 study evaluating the optimal dose and schedule of belantamab mafodotin plus bortezomib, lenalidomide, and dexamethasone (BVRd) for the treatment of transplant-ineligible NDMM (N = 118).
The highest response rates were observed with Q6/8W dosing (ORR, 96%; ≥CR, 88%; MRD negativity, 54%). Within the Q6/8W cohorts, induction with belantamab mafodotin 1.9 mg/kg resulted in deeper responses than the 1.4 mg/kg dose (≥CR, 92% vs 83%). Extended dosing intervals were associated with fewer Grade ≥3 ocular AEs; 86% of first events resolved with Q6/8W dosing, and 100% resolved with Q9/12W and Q12W dosing. These data support the use of belantamab mafodotin 1.9 mg/kg Q8W for 24 weeks, followed by Q12W dosing, in the DREAMM-10 and PrE1005 studies.
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