JOwME retweeted
If you want to nail down #MECFS #pwME subsets.
Fundraise, Promote, and Donate to OMF BioQuest.
The largest ME/CFS Biomarker study with 1000 Samples wants to find a biomarker panel and subsets on a LARGE SCALE.
tinyurl.com/OMFBioQuest1000S…
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Jun 8
Excited to share that I am working on OMF's BioQuest project as part of the computational team 💙🤖🎯
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#MECFS has 18 diagnostic blood tests in development and a genetic role has been discovered.
How do you propose therapy will help T Cell Exhaustion, mitochondrial dysfunction and immune dysfunction?
Full scale testing on 1000 samples began last week on OMF BioQuest.
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OMF’s large-scale biomarker project, BioQuest, is working to incorporate subtype identification into its study. Read more about the project on our website: omf.ngo/bioquest-large-scale….
#MECFS
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Testing began last week on OMF BioQuest
1000 Samples analyzing 10,000 proteins, metabolites, cytokines, and lipids.
Searching for 5-25 Biomarker Panel and #MECFS Subsets.
Donate: 🙏
omf.ngo/bioquest-update/?for…
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I was thinking about the demarcation of MMP-9 in #MECFS patients and healthy controls all weekend. (unpublished - this is based on a poster)
I realize it's a very small n, but the separation seems remarkable. Which is of course why I wrote Dr. Meadows about BioQuest right away.
Timeline cleanse.
@AnilvanderZee posted this weekend about elevated levels of MMP-9 & IL-11 in #MECFS
DOI:10.13140/RG.2.2.36595.08488 Poster
frontiersin.org/journals/imm…
The experiment was in serum.
According to Dr. Danielle Meadows, OMF BioQuest (Plasma) will test MMPs and ILs.
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The elevated levels of MMP-9 and IL-11 were found in serum, while OMF BioQuest is testing MMP's and IL's in plasma. So there cannot be a direct comparison, but it is possible they could find a similar finding in #MECFS plasma according to Dr. Meadows.
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Timeline cleanse.
@AnilvanderZee posted this weekend about elevated levels of MMP-9 & IL-11 in #MECFS
DOI:10.13140/RG.2.2.36595.08488 Poster
frontiersin.org/journals/imm…
The experiment was in serum.
According to Dr. Danielle Meadows, OMF BioQuest (Plasma) will test MMPs and ILs.
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MicroRNAs can distinguish subsets in #MECFS and #LongCovid.
OMF BioQuest is right now testing 1000 samples for 10,000 proteins, metabolites, lipids and cytokines to determine a 5-25 biomarker panel and subsets.
OMF has been planning, building, pursuing this for years.
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OMF BioQuest is testing 1000 samples to find a 5-25 Biomarker test, and ME/CFS subsets.
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Again, we can agree to disagree on that.
The funding situation hasn't changed from the government's side.
But from my point of view the landscape has changed.
There are 18 diagnostic blood tests in development.
There is Decode ME, and OMF BioQuest. There is Sequence ME.
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May 26
The Garden Club of Bermuda donated $48,500 to six local organizations supporting environmental conservation, sustainability, education, and community wellbeing initiatives; BNT, Focus Counselling, Warwick Academy, BEST, BioQuest & Waterstart bernews.com/2026/05/garden-c…
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May 23
@OpenMedF BioQuest testing: underway on 1000 samples. Nightingale runs NMR metabolomics & Olink proteomics. OMF Montreal checks cytokines, haptoglobin phenotypes, SMPDL3B, & markers, while OMF Uppsala adds mass spec proteomics & metabolomics.
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May 22
Of course the donation link provided on the update page doesn't appear to be specific to BioQuest :-/
Hate to quibble but I am running out of patience w their approach to BioQuest donation links. There is still no donation button on the main BioQuest page:
omf.ngo/bioquest-large-scale…
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📢Breaking: BioQuest Update from
Open Medicine Foundation Canada.
Testing has begun on all 1000 BioQuest Samples!!!! #MECFS
omfcanada.ngo/bioquest-testi…
ALT BioQuest update: Testing has been on all Samples The Science is Now in Motion Full-Scale Testing Is Underway We’re excited to share that testing on all 1000 BioQuest samples has officially begun at Nightingale Health, where they are conducting NMR metabolomics and Olink proteomics analyses. But that’s just the beginning. Additional testing will take place at OMF’s collaborative research centers: Montreal Center Our Montreal center will perform a cytokine panel, haptoglobin phenotyping, and immunoassays targeting specific molecules identified through previous research— including SMPDL3B, GDF-15, FGF-21, and BDNF. These tests will reveal critical immune system patterns and inflammatory markers, and validate existing findings. SMPDL3B GDF-15 FGF-21 BDNF Uppsala Center Our Uppsala center will carry out mass spectrometry-based proteomics and metabolomics, along with additional immunoassays—adding even deeper layers of biological insight.
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May 21
OMF reports that its large-scale biomarker project, BioQuest, has begun testing on all 1000 BioQuest sample. Additional testing in Montreal will reveal critical immune system patterns and inflammatory markers, and validate existing findings.
tinyurl.com/mrpx645s
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May 16
Fight for the diagnostic Biomarker (OMF BioQuest) for #MECFS
👀👇
omf.ngo/bioquest-update/
Please donate if you can 🙏
omf.ngo/bioquest-update/?for…
May 16
#GreatestMEdicalScandal
Im Jahr 2009 und erneut im Jahr 2013 lehnte die FDA Ampligen als ME/CFS-Behandlung ab. Es wäre die erste zugelassene Behandlung für diese Erkrankung gewesen.
Als Grund für die Ablehnung wurde das fehlen eines Diagnostischen Biomarkers für #MECFS genannt.
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May 15
I've gone after @amaticahealth for what I see as obvious predatory practices: no peer-reviewed validation, marketing claims that contradict their own disclaimers, buy-now-pay-later financing aimed at chronically ill patients, years of patient sample collection with not even a single preprint to show for it.
But, people say, they're our only hope! At least they're trying to do research! My $1300 brings us closer to a solution!
If you want to do something, you have options. There are research projects and institutions out there that accept donations, both money and specimens. Below, I'll list a few. Some are no longer accepting specimens, but I highlight them to demonstrate the contrast between legit research and a money-making scheme.
1. DecodeME
Built a ~27,000-person cohort and collected saliva DNA from over 18,000 participants. Designed specifically so severely-affected patients could participate.
Did they charge participants $1300? No, it was free.
Did they offer Klarna BNPL for the privilege of donating? Obviously not.
Did they take three years and publish nothing? No: their August 2025 preprint reported 8 genetic loci linked to ME/CFS, analysed across up to 15,579 cases and 259,909 controls.
Is the data locked in a private company? No, they offer access to researchers.
That's how it's done.
2. Open Medicine Foundation BioQuest
A 1,000-sample multi-omics ME/CFS biomarker project. 400 ME/CFS, 400 healthy controls, and 50 each from four comparator groups (MS, exertional malaise/burnout syndrome, clinical depression, and Long COVID). Named investigators and peer-reviewed track record across the OMF Collaborative Centers.
How much did they charge people to collect their samples? Nothing. If you have $1300 burning a hole in your pocket, you can donate.
3. UK ME/CFS Biobank
Over 39,000 samples from 600 donors. Cost to donate? $0.
4. PolyBio Long Covid Research Consortium
Yale, Mt Sinai, UCSF, Johns Hopkins, Penn, Cardiff, Harvard-affiliated groups, and others. Findings published in journals, not Reddit threads.
5. NIH NeuroBioBank
Post-mortem brain and tissue repository that accepts ME/CFS donations. If you're interested, you can register to donate your brain while you're still alive. It won't cost you or your family anything. You can register here:
neurobiobank.nih.gov/donors-…
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