📌 H. pylori Positive – Treatment with Pylera®: Dosing, PPI Need, and Practical Tips
(Updated per ACG & Maastricht VI/2022 guidelines)
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💊 Pylera® Regimen (Bismuth Quadruple Therapy)
Each capsule contains:
•Bismuth subcitrate potassium 140 mg
•Metronidazole 125 mg
•Tetracycline 125 mg
🕐 Dosing:
→ 3 capsules PO QID (after meals at bedtime)
→ PPI BID (e.g., Omeprazole 20–40 mg BID)
📅 Duration: 10 days (can extend to 14 days in some cases)
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❗️Why PPI Is Needed
• Enhances antibiotic stability & efficacy
• Promotes ulcer healing
• Improves H. pylori eradication rate
• Required in all bismuth-based regimens
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📋 Follow-Up
🧪 Test of cure:
→ ≥4 weeks post-treatment (urea breath test or stool Ag)
→ Stop PPI 2 weeks prior to test
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⚠️ Common Side Effects
• GI upset 🤢
• Metallic taste 👅
• Dark stool (from bismuth) 💩
• Photosensitivity (from tetracycline) ☀️
• Neuropathy risk (prolonged metronidazole)
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🧠 Tips for Boards & Practice
🎯 Use Pylera when:
• Previous therapy failed
• Resistance is suspected
• Macrolide resistance or allergy to amoxicillin
📌 Compliance is critical (4x/day x 10 days = 120 capsules!)
🧪 Always confirm eradication for patients with ulcers, MALT lymphoma, FHx of gastric CA, or persistent dyspepsia
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#HPylori #Pylera #Gastroenterology #HemeFellows #PPIs #BoardTips #Infection🦠💊