Nox2 inhibition in APP/PS1🐭#AlzheimersDisease
-⏬Cerebral #CapillaryStalling (neutrophil trapping)
-⏫Arteriole flow
-⏫Short-term memory
A beautiful 2PM paper😍
What occurs to Pericyte on gp91-ds-TAT?😁
@NancyRuizU @OBracko @chris_schaffer bioRxiv 2023
biorxiv.org/content/10.1101/…
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#CapillaryStalling caused by #EndothelialCell #Glycocalyx attrition
#OpticalCoherenceTomography 2PM
Heparinase Hyaluronidase, or🐭#VascularDementia induced by Zoletil xylazine i.p
Mainly Leukocyte plugging
Dr Wang-Yuhl Oh & Yong Jeong labs @_JCBFM 2022
journals.sagepub.com/doi/10.…
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Ablation of 45% adult PDGFRβ #Pericyte in 2 wk ->
⏫🐭Brain #CapillaryStalling
⏬WGA endothelial glycocalyx
⏫EC ICAM1/VCAM1
No Changes in BBB, capillary density/length/tortuosity/RBC flux👈
Dr. Wang-Yuhl Oh & Yong Jeong labs, Front Cell Neurosci 2022
frontiersin.org/articles/10.…
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VEGF-A neutralizing antibody rapidly (< 1h) & sustainably (up to 2 wk) clears brain #CapillaryStalling, restores #CerebralBloodFlow & BBB in APP/PS1 #AlzheimersDisease🐭
Unaltered capillary diameter/density
Dr. Oliver Bracko lab @Brain18782022 @OBracko
academic.oup.com/brain/advan…
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27 Jan 2022
Congratulations to our Muhammad Ali, @OBracko, @BrendahNjiru @stallcatchers @chris_schaffer @NancyRuizU @kaja_falkenhain & other authors for our latest publication! #alzheimers #VEGF #capillarystalling
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