Kerala is already AI capable than rest of India. Outside of BLR,Kerala has immense knowledge base &a dynamic startups culture leveraging Ai wherever possible. Code developer AI still need humans4 writing right prompt & business technical requirements to be defined.

Active mobility ... especially for seniors ... is a much more important consideration than wearing protective gear in normal day-to-day situations for most people ... common sense ... Temporal dynamics of the multi-omic response to endurance exercise training PDF nature.com/articles/s41586-0… Open access 01MAY2024 nature.com/articles/s41586-0… Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1,2,3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository (motrpac-data.org/). Regular exercise provides wide-ranging health benefits, including reduced risks of all-cause mortality1,5, cardiometabolic and neurological diseases, cancer and other pathologies2,6,7. Exercise affects nearly all organ systems in either improving health or reducing disease risk2,3,6,7, with beneficial effects resulting from cellular and molecular adaptations within and across many tissues and organ systems3. Various ‘omic’ platforms (‘omes’) including transcriptomics, epigenomics, proteomics and metabolomics, have been used to study these events. However, work to date typically covers one or two omes at a single time point, is biased towards one sex, and often focuses on a single tissue, most often skeletal muscle, heart or blood8,9,10,11,12, with few studies considering other tissues13. Accordingly, a comprehensive, organism-wide, multi-omic map of the effects of exercise is needed to understand the molecular underpinnings of exercise training-induced adaptations. To address this need, the Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established with the goal of building a molecular map of the exercise response across a broad range of tissues in animal models and in skeletal muscle, adipose and blood in humans4. Here we present the first whole-organism molecular map of the temporal effects of endurance exercise training in male and female rats and provide multiple insights enabled by this MoTrPAC multi-omic data resource.

Temporal dynamics of the multi-omic response to endurance exercise training Open access 01MAY2024 nature.com/articles/s41586-0… Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood1,2,3. Here, the Molecular Transducers of Physical Activity Consortium4 profiled the temporal transcriptome, proteome, metabolome, lipidome, phosphoproteome, acetylproteome, ubiquitylproteome, epigenome and immunome in whole blood, plasma and 18 solid tissues in male and female Rattus norvegicus over eight weeks of endurance exercise training. The resulting data compendium encompasses 9,466 assays across 19 tissues, 25 molecular platforms and 4 training time points. Thousands of shared and tissue-specific molecular alterations were identified, with sex differences found in multiple tissues. Temporal multi-omic and multi-tissue analyses revealed expansive biological insights into the adaptive responses to endurance training, including widespread regulation of immune, metabolic, stress response and mitochondrial pathways. Many changes were relevant to human health, including non-alcoholic fatty liver disease, inflammatory bowel disease, cardiovascular health and tissue injury and recovery. The data and analyses presented in this study will serve as valuable resources for understanding and exploring the multi-tissue molecular effects of endurance training and are provided in a public repository (motrpac-data.org/). Regular exercise provides wide-ranging health benefits, including reduced risks of all-cause mortality1,5, cardiometabolic and neurological diseases, cancer and other pathologies2,6,7. Exercise affects nearly all organ systems in either improving health or reducing disease risk2,3,6,7, with beneficial effects resulting from cellular and molecular adaptations within and across many tissues and organ systems3. Various ‘omic’ platforms (‘omes’) including transcriptomics, epigenomics, proteomics and metabolomics, have been used to study these events. However, work to date typically covers one or two omes at a single time point, is biased towards one sex, and often focuses on a single tissue, most often skeletal muscle, heart or blood8,9,10,11,12, with few studies considering other tissues13. Accordingly, a comprehensive, organism-wide, multi-omic map of the effects of exercise is needed to understand the molecular underpinnings of exercise training-induced adaptations. To address this need, the Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established with the goal of building a molecular map of the exercise response across a broad range of tissues in animal models and in skeletal muscle, adipose and blood in humans4. Here we present the first whole-organism molecular map of the temporal effects of endurance exercise training in male and female rats and provide multiple insights enabled by this MoTrPAC multi-omic data resource.

Over The Course Of His Life, Jimmy Carter Has Almost Brought An End2 A Destructive Parasite That Has Plagued Humans4 Thousands Of Yrs! cnn.it/3lZKOXu @SarahRudolp @jboogiebrown @elvislver56 @mnewsince @TheOralBuffet @SpeakTruth911 @stephanie_dews @CarolynAILG @philly_nj

Why? Because it is a silly question? Is it? I know nothing about Islamic culture, do you know? If there's another rationale (if it can be called that) 4 gang rapes, I wud like to know, or is it just sick, depraved human beings doing this to other humans4 kicks & giggles?

Having failed moral test by trading vulnerable humans4 political expediency, hope Ms Patel will pass democratic test by ditching plan.YouGov survey 42% population against plan 35%yes. Head Church of England,Head Labour Party Starmer, Fmr PM Rt Hon Theresa May,160 NGOs oppose it.

47⚫ag√. #SaneTerrorizedAmeRussians😷 seeking clarity@ Y humans prey on othr humans4 constructs of wealth & fame superiority ~ 🤔 how #WhiteInvaderHeritageSuperiorityOnly Xploits 😱&🙏🙌of mythical power 4their #GenocidalOppressivePredation @yappydagger

“With about 97% of the planet’s land surface ravaged by humans4, nature is facing its last stand” Rewilding Argentina: lessons for the 2030 biodiversity targets #WorldRewildingDay nature.com/articles/d41586-0…

In case you missed it: peep @gilbertmezcal's interview with Ilegal Market Manager founder of Humans4, Herminio Torres → youtu.be/pxjWnR-UvMI Humans4.org is a non-profit aimed at helping strengthen local communities through various missions

TOMORROW • Herminio Torres joins Gilbert Marquez for a conversation about his work with Humans4, helping to feed undocumented families affected by COVID-19. Save the date! ilegalmezcal.lnk.to/newsspec…

Why don't they just bring Humans back? It was incredible. I was hooked. @AnitaSynth @HumansLeo @NiskaHumans @headdump_mattie #Humans #Humans4 #Hum4ns

WTF!!!!!!!! Why was Humans cancelled? #Humans #AMCHumans #HumansAMC #RenewHumans #RenewAMCHumans #HumansSeason4 #Hum4ns #Humans4 @AMC_TV @HumansAMC

THIS KILL SHELTER IS A TORTURE CAMP FOR DOGS, BEST HUMANS4 FRIENDS!!!!☠️😿

Recalibrating.... Loading location..... ERR0R#UNAUTHOURISEDACCESS/NOTFOUND #Hum4ns #HumansAMC #Humans4

/##%< I M H E R E >%##/ #Humans #HUMANSamc #hum4ns #Humans4 #Hum4ns

A new tomorrow awaits us in time, Laura. We have died, fought, for us all. For a future. I hope people don't lose the hope we tried to keep alive. @LauraHumans #HUMANSamc #Humans #Humans4 #Humans3 #Hum4ns

Life. Death. Rain, rotting, rebellion. Opting to trade my freedom for theirs. #Humans3 #Humans4 *sits in cell, hearing rain drops outside* 🌧️⌛️

When you party with an Elster you know the vibe will be electric! #Humans4 #Hum4ns

I miss you. #Humans4 #HumansAMC #Hum4ns #Humans3

At least I get the latest upgrades... #HumansAMC #Humans3 #Humans4 #Hum4ns