The average global citizen is so quick to trust the people who have contributed to building this beast system and a lot of researchers and scientists won't admit that they have been manipulated, deceived, and even lied to. Unfortunately we have a class of individuals who set the global policies in healthcare and BIG HARM YA (pharma) and their intention for the global population is to have complete control over them down to the neuron and down to the atom!!! The technologies are dual use and they sell it to people as something GOOD, a wonder cure!! Example: “We have this nanoparticle (NP) that has a molecular payload encapsulated by WHO KNOWS WHAT can be moved throughout the body and target cancer cells and kill them!! Just know that if they can do that then they can also harm you with bioactive materials by creating these heterogenous nanostructures that are used to exploit human energy and harvest it. MAGNETIC CARRIERS (MCs) Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers (MCs) open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. These magnetic carriers (MCs) can be formulated by enriching or combining conventional constituents of micro/nanocarriers (lipids, proteins, polymers, or inorganic materials) with magnetically active components with ferromagnetic, paramagnetic, or superparamagnetic nature. For example, one magnetic component that is typically used is iron oxide, extensively applied in the form of particulate material, like iron oxide nanoparticles (IONPs). MCs can serve as contrast agents in magnetic resonance imaging (MRI), but as they can be functionalized with diverse imaging tags, they can be also visualized by other imaging techniques. Therefore, the magnetic nature of the MCs offers the unique chance to remotely control the localization and therapeutic action of bioagents, while visually monitoring the targeted delivery process. In addition, the micro and nano-capacities of these systems make it possible to load therapeutics of various types, ranging from small molecules to nucleic acids and cells. Sensitive bioagents can be protected by encapsulation within internal compartments of larger systems, like microcapsules. Nanosized MCs, like nanoparticles (NPs), can be surrounded with surface coatings that provide accessible sites for conjugation with functional molecules. Such versatility has promoted the use of MCs in a plethora of advanced biomedical applications that include genetic engineering, gene therapy, cell therapy, microrobotics, and tissue engineering. For these applications, MCs have been engineered as multifunctional platforms that combine mechanisms of controlled drug release, activatable cytotoxicity, spatial guidance, and multimodal imaging. pmc.ncbi.nlm.nih.gov/article… Nanoparticles (NPs) can be moved, guided, and concentrated throughout the human body using magnetic fields in a technique often combined with magnetogenetics and targeted drug delivery systems. While sometimes used interchangeably in popular media, magnetic targeting (using magnetic fields to move particles) and magnetogenetics (using magnetic fields to activate genetically modified cells) are often combined to achieve precise, non-invasive “therapeutic” control. REMOTE DRUGGING!! YOU WONT EVEN KNOW THE DOSAGE!!!!! pmc.ncbi.nlm.nih.gov/article…

スルホキシドを導入したPEGで、免疫原性を抑える pubs.acs.org/doi/10.1021/pol… この論文は、ナノ医療分野で広く使われているPEGに代わる新しいポリマーとして、ポリ（2-(メチルスルフィニル)エチルグリシジルエーテル）(PMSOEGE)を報告しています。PEGは優れた生体適合性と防汚性を持つ一方で、免疫原性が問題視されていました。 PEG骨格にスルホキシド構造を導入することで、PMSOEGEを合成しました。このポリマーは、従来のPEGよりも高い親水性を示し、優れた生体適合性も持っています。 PMSOEGEは、抗PEG抗体との結合親和性がPEGよりも著しく低いことが示されました。PEG主鎖を認識するmAbを使った競合ELISAでPMSOEGEはPEGより300倍以上弱く結合しています。 これは、PEGが引き起こす免疫原性のリスクを軽減する可能性を示唆するものです。 さらに酸化鉄ナノ粒子（IONPs）にPMSOEGEをコーティングしたところ、PEGをコーティングしたナノ粒子に比べて、マクロファージによる細胞内取り込みが大幅に減少しました。過去にスルホキシド系ポリマーはタンパク付着とマクロファージ取り込みを大幅低減し、PKを改善するとの報告があり（PMSEAなど）、今回の結果はその系統の延長線上にきれいに乗っています。 ヒト血漿にナノ粒子を浸した実験では、IONP@PMSOEGEに付着するタンパク質の量がIONP@PEGよりも2.5分の1に減少しました。このことから、PMSOEGEが優れた防汚性能を持つことが明らかになりました。 抗PEG交差性評価はmAbのみで実施していますので、CARPA（補体活性化反応）やABC現象（反復投与後の急速クリア）の評価は必要になってくるかと思います。まずは齧歯系であたりをつけて、大型動物での安全性・免疫原性という流れでしょうかね とはいえ現時点でのデータは有望であり、PMSOEGEは、ナノ医療を含む様々な生物学的応用において、より安全で効果的な「ステルス」材料としての可能性があります。さらなる評価結果を期待したいです。 Polymer Science & Technologyより。OAです

Highly Cited Paper on nanomedicine Green-synthesized iron oxide nanoparticles (IONPs) show promise as antimicrobial agents. This review covers synthesis methods, challenges, and biomedical potential. 🔗mdpi.com/2553080 #IONPs #GreenNanotech #Antimicrobial #Nanomaterials

Enhancing ligand accessibility on nanoparticle surfaces improves tumour antigen recognition, binding, and penetration — a proof-of-concept with IONPs targeting EGFR for enhanced photothermal therapy. @AlxDetappe @HarleppS @SBeginColin Read more here: doi.org/10.1039/D4NR02931C

Ferrofluids : 🧲 This are colloidal suspensions of iron oxide nanoparticles (IONPs) within aqueous or nonaqueous liquids that exhibit strong magnetic properties. These magnetic properties allow ferrofluids to be manipulated and controlled when exposed to magnetic fields.

Working with CINT — In this research, a team of CINT Users sought to investigate and overcome optical interference of IONPs in colorimetric, fluorometric and luminescence assays. sciencedirect.com/science/ar…

Our new paper highlights the potential of soil bacteria in IONPs Synthesis, iron tolerance and some iron-reducing genes responsible for the bio-reduction mechanism. Many thanks to @wara and @MastercardFdn for the support. authors.elsevier.com/a/1iDoI…

Lookin' for some hot stuff🎤? Particle tuning via engineering. Modular high-temperature flow reactor with @AG_Lab_UCL and @palsayan3 yields 2-20 IONPs from the same precursor solution. See @Chem_Eng_J for doi.org/10.1016/j.cej.2023.1… #HotStuff #FlowChemistry #ParticleEngineering

New Research: In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model: Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic… frontiersin.org/articles/10.… #immunology

We are very happy to share our cover @ChemMater highlighting our latest paper doi.org/10.1021/acs.chemmate… If you did not read it yet, go to take a look and discover how we are able to tune the MRI properties of IONPs by protein engineering. ⬇️⬇️ @CICbiomaGUNE @Ikerbasque @brta_eus

Hi @LatinXChems, this is my work "Graphene-IONPs nanocomposite for hydrogen peroxide detection by electrochemical method", #LatinXChem22 #LXChemNanoMat #NanoMat108 #FQ_UH #LBI

Things you can do in a microwave. Continuous nanoparticle synthesis utilising microwave irradiation. #IONPs #ParticleTechnology #ReactorTechnology #FlowChemistry

Last flash before ☕️ by Neus Daviu “Increasement of Oxidative Stress by IONPs alters mitochondrial bioenergetics and mitochondrial dynamics in cancer cells” @CNB_CSIC

Bravo to @JoanaVazRamos and @aanyula for their talks on IONPs for health and depollution at 8th EuChemS Chemistry Congress #EuropeanChemicalSociety #Lisbon2022 @EuChemS_Congres @IPCMSlab

Cell Culture >> IONPs > Cell culture

All of the CFNPs had fairly different magnetic parameters than the IONPs — significantly larger coercivity and remanance values! This means these behave as permenant mini-magnets themselves, and ALSO respond to an external field. This vid shows how strong they are! (23/?)

Then the task was to design a "deconstructed" version of the Fe3O4@Au core-shell sensors, using the gold layer in a more background role, and the IONPs at the surface of the design... (9/)

But eventually, I made reliable magnetic IONPs! Here are some scanning electron microscope images of them 💪🏼🧲 (left: plain as-made NPs; right: organosilane-capped w/ APTES) (8/?)

I noted that many of these studies around the time tended to ignore any contributions of the iron oxide nanoparticle (IONP) cores to the SERS activity, despite them often being in local range of the sensing surface! The IONPs: (4/?)

A fouling free flow reactor for precipitation syntheses (and more). An elegant upgrade of coaxial flow reactors well designed tubular reactors simple chemistry for stable IONPs = fouling free continuous co-precipitation synthesis #FlowChemistry #FoulingFree #NanoParticles