husband, father, medical physicist and nano-scientist, innovator and entrepreneur. opinions are my own
Joined August 2013
- Tweets 694
- Following 1,736
- Followers 887
- Likes 1,862
80 Photos and videos
Alex Detappe retweeted
Jun 4
A very impressive study for how we could prevent lung cancer more than 5 years before it is diagnosed. Using machine learning, discovery of a 14-plasma protein signature of risk that predicts responsiveness to an antibody therapy to interleukin, IL-1β
Validated across 8 cohorts
@CellCellPress @CharlesSwanton
cell.com/cell/fulltext/S0092…
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May 29
New preprint on bioRxiv: Hydrogel confinement enables subcutaneous delivery of vesicant antibody-drug conjugates.
We observe that:
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May 29
• Platform generalization across T-DM1, T-DXd, trastuzumab and enfortumab vedotin establishes that the determining variable is payload pharmacology rather than target or conjugate chemistry.
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Apr 22
ADC are IV-dominant. Biology permits SC. Engineering blocks it. Our J Controlled Release perspective details what's needed: conjugation chemistry, high-conc formulations (>100 mg/mL), biomaterials, devices.
sciencedirect.com/science/ar…
@ERC_Research @laliguecancer @GustaveRoussy
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Mar 30
Thanks a lot for inviting me! It was a blast meeting you all!
Mar 11
Amazing A. Detappe! Liposomal nanoformulations, ultrasmall gadolinium-based nanoparticles & polymer-nanoparticle hydrogel are being developed to enable at-home administration of hospital-restricted biologics. Efforts to shorten the path from bench chemistry to patient benefit.
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21 Nov 2025
New in @NatRevBioeng w/ @FAndreMD
: No targeted nanomedicines approved despite preclinical tumor accumulation. Our thesis: It's not poor delivery, it's static formulations in a dynamic disease. Time to test adaptive nanomedicine. Thanks
@ChristineHorejs!
rdcu.be/eQ6J5
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20 Nov 2025
Our latest paper in @ACSNano is out! 🤩
We built tiny peptide-based “delivery vehicles” that bring heavy metals (Gd, Bi, Hf) to tumors so we can fairly compare how well each one boosts external radiotherapy and radioligand therapies.
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20 Nov 2025
Big congrats to Dr. Sebastian and our amazing collaborators for making this happen 🙌
If you’re interested in smarter radioenhancers and “see & treat” oncology, check out the paper:
🔗 pubmed.ncbi.nlm.nih.gov/4125…
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22 Sep 2025
Thank you @le_Parisien @leparisien_94 for being with us at @GustaveRoussy on this special day. It’s not just about a new building, but about pushing research forward and giving more hope to patients.
16 Sep 2025
« Les patients attendent beaucoup de nous » : face au cancer, Gustave-Roussy offre un écrin tout neuf à ses chercheurs l.leparisien.fr/FYHW
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Alex Detappe retweeted
17 Sep 2025
📰 « Les patients attendent beaucoup de nous » : face au cancer, @GustaveRoussy offre un écrin tout neuf à ses chercheurs.
Les Prs Fabrice @barlesi et @FAndreMD rappellent l’ambition de l’institut dans @le_Parisien ⤵
leparisien.fr/val-de-marne-9…
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Alex Detappe retweeted
17 Sep 2025
#IMS25 In my mind, this will be the slayer of ASCT more than any other #MMsm regimen...
Excellent Tec-DVR & Tec-DR data [1x weekly Velcade & lots of IVIG 👏] in NDMM from MajesTEC-5 @RaabMarc
100% ORR, 100% MRD neg across the board. This is what we hope for with induction!
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Alex Detappe retweeted
17 Sep 2025
📰 De nouveaux laboratoires de #recherche pour @GustaveRoussy sur le Campus Grand Parc.
Sept équipes de chercheurs de Gustave Roussy s’installent dans des locaux de 850 m² d’un nouveau bâtiment, le LAB 116/Perelis. Actuellement en plein développement autour de l’Institut, le Campus Grand Parc est amené à devenir le plus vaste ensemble entièrement dédié à la #cancérologie en Europe 🇪🇺.
En savoir plus ➡ gustaveroussy.fr/fr/news-de-…
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18 Jul 2025
Inspiring week at #CRS2025 - my first @CRSScience conference, and I truly loved it! Grateful for the vibrant community, meaningful discussions, and new collaborations taking shape.
Special thanks to the @CRS_FG_NANO for the award - honored and motivated!
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