TRIM — Memory beyond T & B cells! Innate cells remember too. 🧠🔥 • First hit (BCG, β-glucan, infection) → epigenetic & metabolic rewiring • Next hit → stronger, faster, non-specific immune burst • Acts via monocytes, macrophages, NKs, progenitors • Boosts defense ✅ • But overdrive = inflammation/autoimmunity ⚠️ • Big potential for vaccine design & immunotherapy 🧬 🧩 Mechanism = histone marks glycolytic shift → “trained” state 📖 Latest Review: Trained Immunity: Reprogramming innate memory 👉 DOI: 10.1007/s11886-024-02167-7 (2024) #TrainedImmunity #InnateMemory #Immunology #Epigenetics #Vaccinology

Very proud moment 😊- the 1st paper of our lab has just been published: science.org/doi/10.1126/scii… This tour-de-force work was bravely headed by the fantastic @MaryemRadhouani, showing that #Eosinophils develop #InnateMemory upon skin #infection with implications for lung #allergy

Very excited and proud of the first lab paper 🥳! Our study led by PhD student extraordinaire @MaryemRadhouani finds that #SkinInfection induces #InnateMemory in #Eosinophils with consequences for #lung #allergy science.org/doi/10.1126/scii… Also check out the thread by Mariem!👇

A deep understanding of how the BCG vaccine has long-lasting effects on innate immunity and the prevention of infectious diseases other than tuberculosis. #BCG #innatememory #vaccines sciencedirect.com/science/ar…

#WeekendRead! #InnateMemory! Hall &co show @ScienceAdvances that infection with #Salmonella changes hematopoietic stem cells via C/EBPb to produce #neutrophils with elevated bactericidal capacity thanks to increased mitochondrial ROS! doi.org/10.1126/sciadv.adf99…

#WeekendRead. #InnateMemory! Ma, Zeng, &co show @CellReports polymicrobial #sepsis sensitizes mice to a second microbial challenge by training granulocytes to potentiate glycolysis & via epigenetic inactivation of TLR4 inhibitors, leading to 👆 TNF & death!doi.org/10.1016/j.celrep.202…

#InnateMemory! ⁦@jalees_rehman⁩ &co show @JExpMed⁩ that previous #lung exposure to LPS or Gram-negative bacteria increases efferocytosis by alveolar macrophages via KLF4-MERTK, thus favoring resolution & dampening damage upon microbial reencounter rupress.org/jem/article/220/…

#InnateMemory! Ucar, Josefowicz, &co show that upon #SARSCoV2 encounter, hematopoietic progenitors of the bone marrow (mirrored in peripheral blood) are reprogrammed by #IL6 to give rise to inflammatory & tissue migrating monocytes/myeloid cells! doi.org/10.1016/j.cell.2023.…

Great few days on innate immune memory! #innatememory #trainedimmunity #innateimmunememory @NatImmunol @SpringerNature @nature

A village model of tissue resident and recruited macrophages, finally suggesting "Yes, targeting the proliferative resident macrophages would be the most effective to limit inflammatory signaling" #macrophage #pluripotentstemcells #innatememory #inflammation @innatelyscience

Wanna know more about #innatememory? Check our last review from @el_deusu @FricLab "Train the Trainer: Hematopoietic Stem Cell Control of #TrainedImmunity" frontiersin.org/article/10.3… @FNUSA_ICRC @IHBTcelltherapy

Our story @el_deusu @FricLab @ForteGiancarlo @FNUSA_ICRC "Sepsis induces long-term reprogramming of human hematopoietic stem cells" as selected talk @2021ECI ! Sept 2, 17.43, Hall10 Congratulations Marco!!! #ECI2021 #immunology @y_efis #InnateMemory #TrainedImmunity

Our review on trained immunity and host-pathogen interactions is out in @CellMicrobiol @WileyGlobal onlinelibrary.wiley.com/doi/… #hostpathogen #trainedimmunity #innatememory #bacteria

Our latest paper with @EdLavellee is now available to read online! Click the below DOI for pHBADs and work on innate memory. doi.org/10.1021/acschembio.0… @tcdTBSI @TCD_Chemistry #InnateMemory #IrishResearch #IrishChemistry #Rhamnosides

Strong examples as to why #science, & #immunology particularly, is so cool! Such awesomeness is indeed worth sharing! Check out this insightful & easy-to-follow podcast by @profvrr, @CindyLeifer & @stephanielangel on #innateMemory #adaptiveNK & their applications! #scienceEd

Clara Lorente-Sorolla just made a great defense of her thesis on #epigenetics #sepsis and #innatememory. We are a proud lab today! @CarrerasIJC

I like when nature reminds us our concepts are insufficient #innatememory #immunology #vaccines #innateimmunity Human natural killer cells mediate adaptive immunity to viral antigens immunology.sciencemag.org/co…

#InnateMemory | Memory-Like #NaturalKillers against Leukemia | ToddFehniger @WUSTL @ScienceTM ow.ly/laRl304tAl5

#InnateMemory | Memory-Like #NaturalKillers against Leukemia | ToddFehniger @WUSTL @ScienceTM ow.ly/laRl304tAl5

#InnateMemory in Allergy | ILC2 acquire memory-like properties | FumioTakei @UBC @immunityCP ow.ly/ZbRz302b4tK