The #keedylab '024 paper deluge continues! Tamar and I worked with @helen_m_ginn to computationally reveal, model, and analyze 50% more ligand-bound structures that had been lurking unnoticed in our fragment screening data. Here's the @biorxivpreprint: biorxiv.org/content/10.1101/…

First #keedylab paper of '024! Our paper on "high-resolution double vision" of PTP1B is out now in @ActaCrystF, with some nice improvements over the @biorxivpreprint version. Check it out here: doi.org/10.1107/s2053230x230…

💎 New #keedylab Preprint💎 biorxiv.org/content/10.1101/… We stumbled upon the highest-res dataset for apo WT PTP1B (n=350 total PTP1B structures @buildmodels). The 2 protein chains have diff degrees of disorder - allowing a direct, controlled comparison of protein conformation(s).

New #keedylab preprint! We ventured out of the crystal lattice and into solution this time. Our favorite protein wiggles & jiggles in surprisingly different ways when bound by a ligand over here vs. over there. Read all about it here: biorxiv.org/content/10.1101/…

Check out our latest #KeedyLab @biorxivpreprint! We compare the effects of physiological temperature vs. high pressure in crystal structures of STEP - a validated therapeutic target for #Alzheimers and #Parkinsons Coming soon to a journal near you! biorxiv.org/content/10.1101/…

New #keedylab #preprint! How does a protein structure differ at physiological temp vs. high pressure (vs. traditional cryo temp)? Liliana Guerrero (Margent) & @DrAliEbrahim looked into it: doi.org/10.1101/2023.05.02.5… Great collab w/ Qingqiu Huang & Aaron Finke at @MacCHESSCornell !

Kicking off the holiday season early with this unbelievably thoughtful and undeniably awesome gift from the #KeedyLab Secret Santa 🎅🏼 You know you want one @dorbitalgames

The fruits of an awesome body of work coming out of the KeedyLab! A super interesting read - all involved have absolutely smashed this. Congrats!!

We had an invigorating #keedylab journal club meeting this week about this paper by Yabukarski et al. from the Herschlag group: biorxiv.org/content/10.1101/… Turns out specific radiation damage is not a big deal for room-temp crystallography, if you do things right! *phew*

Spring 2021 #keedylab news roundup, including new faces, papers, and fellowships: keedylab.org/news/

It was great to have a fellow @RhodesCollege #lynx in the #keedylab for the summer!

The new resident @OpenTrons_ experts in the #keedylab ( @angel_mway and Tamar Skaist) running our first protocol!

The #keedylab at the @asrc_gc in #nyc is looking for a postdoc! We have exciting plans to use experimental computational crystallography to dissect protein allostery. Apply here: cuny.jobs/new-york-ny/resear… Learn more at our new website: keedylab.org And please RT!

If you're at #ACSOrlando, come see me talk about cryptic sites in a dynamic enzyme tomorrow morning, April 3 from 10:50-11:25! I will NOT be cryptic about the site of said talk: room W331A. #allostery #keedylab

Thanks to the @GC_CUNY Biochemistry Program for this "spotlight" on the #keedylab at the @asrc_gc: gc.cuny.edu/sciences/spotlig…