This morning at ENDO 2026, a single oral dose produced a calcemic effect lasting approximately three days in non-human primates. That is not an injection. That is an EB612 tablet, and it is Entera Bio's case for replacing injectable PTH with a once-daily pill.
globenewswire.com/news-relea…
$ENTX laid out the preclinical package across three models: in the TPTx rat, seven days of dosing restored serum calcium and reduced phosphate to levels matching healthy sham controls. In minipigs, plasma concentrations peaked 2-3 hours post-dose and remained detectable for more than three days. In non-human primates, the three-day calcium elevation was accompanied by measurable suppression of endogenous PTH.
No safety concerns were identified across any of the three models. The calcemic effects were described as consistent with clinically validated injectable PTH replacement therapies. The OPKO Health partnership, restructured in February 2026 onto a 50/50 basis, funds the program through Phase 1.
Next catalyst: IND application with the FDA expected in late 2026.
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Jun 15
Most people don’t know that ICH requires at least two preclinical safety/toxicity studies in mammalian species before human trials can start. So pharma companies tests on mice and commonly dogs, minipigs, or non-human primates.
RFK Jr is pushing to change for international markets, which is a welcome and many companies run these test in other parts of the world!
Jun 15
RFK Jr. & Brooke Rollins cracking down on dog breeding mills!
As some of you, may or may not know, I was heavily involved in dog rescue, foster care, and adoption services for rescue and shelter dogs. This issue is so important, and the more you learn about what happens in this industry, the more you will be disgusted.
The administration is launching coordinated strikes via USDA, DOJ, HHS to shut down puppy mills, enforce Animal Welfare Act, and end the cruelty. Bad actors’ time is up. Adopt, don’t shop.
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Jun 15
Most people don’t know that ICH requires at least two preclinical safety/toxicity studies in mammalian species before human trials can start. So pharma companies tests on mice and commonly dogs, minipigs, or non-human primates.
RFK Jr is pushing to change for international markets, which is a welcome and many companies run these test in other parts of the world!
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Jun 15
A team from Zhejiang University presented a breakthrough published in the journal Nature: needle-free insulin delivery. Thanks to the innovative OP polymer, insulin can cross the skin and reach the bloodstream safely, comfortably, and painlessly.
Originally developed for cancer therapies, the OP polymer overcomes the skin's natural barrier by interacting with its pH gradient. On the surface, it acquires a positive charge, and as it descends into deeper layers, it becomes hydrophilic, moving between cells to transport large molecules without compromising skin integrity.
Trials with the OP-I formula in diabetic mice normalized glucose levels in less than an hour, maintaining the effect for more than twelve hours and reducing the risk of hypoglycemia. Tests on minipigs confirmed its safety and efficacy without causing irritation, suggesting the great potential of future patches or creams.
The scope of this platform goes far beyond diabetes, as the polymer can transport other biological medications such as GLP-1 drugs (liraglutide and semaglutide), monoclonal antibodies, and siRNA. The technology already holds an industrial license and is steadily advancing toward human clinical trials.
DOI: 10.1038/s41586-025-09729-x
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herrrrrrrrrrrrrrrrrrrrrrrp we took over the store, but we don't go looking in every nook and cranny when we take it over......... even though we are corporate and we had a hostile takeover and the lady was trying to explain it to us on exit.
GO GET FKIN REKT Dicks and Minipigs!
Jun 11
NEW: Coffeezilla confronted the Bricks and Minifigs CEO over access to a master spreadsheet that explicitly logged the high-value Star Wars LEGO sets belonging to Mansell.
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Jun 10
the gofundme got taken down, literally the only thing that accomplishes is further denying an elderly man the money he deserves, Bricks and minipigs is a truly vile and evil corporation
Jun 9
BREAKING
Reckless Ben aka Ben Schneider has been silenced by Bricks & Minifigs via a Lawsuit filed by CEO Ammon McNeff
He no longer can mention their name otherwise ALL GoFundMe money raised will be forfeited & he will be jailed
This is all over Legos BAM stole
VIDEO LINK
youtu.be/sISjfdueTYg?si=GA3P…
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F*CK D*CKS AND MINIPIGS!!!
they will shut down and lose the lawsuit!
Jun 9
be a shame if EVERYONE started making videos about bricks and minifigs
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oh no! president trump has now gotten involved in this figs and minipigs bullshit and demands they give brians legos back!
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love this ty uh oh president trump has now gotten involved in this figs and minipigs bullshit and demands they give brians legos back!
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May 29
Please please read this thread! @JTLonsdale
I respect you. This is respectful disagreement on the approach.
As I said, im with you, but instead of inefficiently screening 100 monkeys, we need to screen one or two until even that’s not needed.
And BTW - by the time that one of your monkey models is ready, Cleopatra, for 1/100 the cost per drug, can screen thousands.
So it’s actually synergistic. My disagreement: we need to focus on HUMAN ORGANOIDS at @precigenetic FIRST
Then we go to animal
And then, slowly, animal models will not be needed at all.
Each monkey model costs $1.5-2M.
We do our screens for $75k-$350k and we already have pharma’s signed for it!
So as I said. It shouldn’t be “hundreds and hundreds” of monkeys. And it can’t ONLY be primates either.
Minipigs show a lot of immune response that monkeys CANNOT show and humans do.
x.com/parmita/status/2060374…
May 29
@JTLonsdale is right about the thing that matters most: this is a national-security problem, not a science-fair debate. china going after US biotech is real. the supply chokehold is real. his instinct to build domestic capacity now is correct.
We disagree about what to build.
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May 29
I didn't know that. The grants to the Kurchatov Institute and to Vorontsova are public, as is the bioprinting and the minipigs (they talked about it in interviews). But it's a great article
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May 29
⚡️In the pursuit of longevity, vladimir putin has allocated $26 billion for anti-aging research, — according to The Wall Street Journal.
According to the publication, russian scientists are working on gene therapy, tissue bioprinting, and growing human organs inside minipigs.
The projects are overseen by the dictator’s daughter maria vorontsova and physicist mikhail kovalchuk, who is considered one of the scientists closest to the kremlin.
👉Follow
@blyskavka_ua
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May 24
the minipigs are a specific breed, so even the adults are pretty small. i played with a baby and two adults!
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Even during a down pour, the pigs demand their meals on schedule! 😂🐷 #pigs #minipigs #animalsanctuary
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