1) Watched this presentation by Dr. Steve Gardner from PrecisionLife. Their genetic analysis suggests that ME/CFS is highly polygenic and heterogeneous. They are using their data to make drug repurposing trials more effective, for example on GLP-1 receptor agonists.

Thanks, perhaps good to point out that PrecisionLife is a private biotech company aiming to make an earning out of this and which regularly sends out press releases about their findings.

5) Precisionlife has been using its AI-driven combinatorial analytics platform to find genetic drivers of GLP-1 efficacy so that they can predict and stratify strong and weak responders. More info: precisionlife.com/glp1

Wins don’t arrive loud. They settle in quietly after the work stacks up. Control the details, trust the process, and let the result speak for itself. 🏆 #Darts #CauseAndEffect #BuiltToWin #PrecisionLife #DartPlayers

#BRMEC15: GLP-1 RAs - Hype, Hope and Hidden Dangers A rare published presentation from our colloquium - Dr Steve Gardner of PrecisionLife on GLP-1 receptor agonists and what the science means for ME investinme.org/brmec15-steve… #IMECW2026 #MEcfs #research

The PrecisionLife Study on MECFS showed disturbed CLOCK genes which regulate function through the SCN. A recent preliminary study shows deficient norepinephrine. Whether by genetic or epigenetic fluctuations, the CLOCK is an important regulator in MECFS, especially after an illness or other disturbance of homeostatic stability. "The SCN through both direct neural projections and indirect multisynaptic pathways, communicates circadian timing information to other regions, including the locus coeruleus (LC), the dorsal raphe nuclei (DRN), and the tuberomammillary nucleus (TMN), which releases histamine (Van Drunen and Eckel-Mahan, 2021; Scammell et al., 2017). Within the arousal network, the LC release norepinephrine to promote wakefulness and cognitive alertness, while the DRN releases serotonin, contributing to transitions between wake and NREM sleep. The TMN provides histaminergic drive that sustains cortical activation during wakefulness. The ventrolateral preoptic area (VLPO), by contrast, exerts GABAergic inhibition on these arousal-promoting regions to initiate and maintain sleep. Circadian SCN signaling to both the vLPO and LC-TMN-DRN axis ensures that sleep pressure is expressed at the biologically appropriate phase." IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications - PMC share.google/gQjPhO2bVPMUlUa…

Cort Johnson speaks 2 PrecisionLife CEO Steve Gardner whose latest study used genetic data from DecodeME vs UK Biobank. Their goal is to identify core genes driving illness & then reduce their expression & in finding drugs that work in ME/CFS & long COVID. tinyurl.com/3v59k3dy

This is interesting because one of the PrecisionLife studies showed altered CLOCK in MECFS!

PrecisionLife, Ovation move to decode GLP-1 response with predictive genomics firstwordpharma.com/story/71…

PrecisionLife, Ovation.io report genetic markers that predict GLP-1 response @ovation_io @precisionlifeAI #obesity #diabetes #biomarkers firstwordhealthtech.com/stor…

3) The project brings together collaborators from: - University of Melbourne - La Trobe University - Monash University - Baker Heart and Diabetes Institute And global partners such as PrecisionLife.