Gleason grading #pathology #uropath #prostatepath #pathtweet

#PathQuiz 🔬 A) High-grade prostatic intraepithelial neoplasia B) Intraductal Carcinoma of the Prostate C) Conventional Acinar Adenocarcinoma D) Prostatic Ductal Adenocarcinoma #Pathology #GUPath 🧬 #ProstatePath

✅ Incidental amyloid deposition ✅ in the seminal vesicles identified in a prostate specimen. H&E demonstrates amorphous, extracellular eosinophilic stromal deposits. Congo red confirms amyloid with classic apple-green birefringence under polarized light. Examination with fluorescence microscopy enhances sensitivity and contrast for detecting the deposits. Seminal vesicle amyloidosis is typically localized and age-related, most often derived from seminal vesicle secretory proteins, and is usually not associated with systemic amyloidosis in the absence of clinical findings. #Pathology #GUPath #Amyloid #CongoRed #ProstatePath 🔦Key Literature References • Westermark P, Benson MD, et al. Amyloid fibril protein nomenclature—2016 recommendations. Amyloid. 2016. • Linke RP. Highly sensitive diagnosis of amyloid and various amyloid syndromes using Congo red fluorescence. Virchows Arch. 2000. • Coyne JD. Amyloidosis of the seminal vesicle: a common incidental finding. J Clin Pathol. 1997. • Benson MD, et al. Localized amyloidosis: review and classification. Blood. 2018.

If it’s cribriform, it’s never Gleason 3. Pattern 4 until proven otherwise 😌🔬 Pattern 3 = well-formed, discrete glands only ❌ Cribriform = fused gland architecture → Pattern 4 Pattern 5 requires solid sheets, cords, or necrosis #PathTwitter #ProstatePath

This gray area type case I'm finding challenging. Your input is greatly appreciated. 2 prostate core sites, A and B. What would you dx for them? PTEN is intact in all tissue in A and B. #GUPath #ProstatePath #PathTwitter #PathX

#prostatepath collagenous micronodules (aka mucinous fibroplasia) #gupath

#gupath #prostatepath grade or not to grade? finasteride 5 mg daily ~2 years for BPH/LUTS 🗳️ poll below, comments welcome 🤗

#prostatepath have U seen case of P.H.Adeno CA prostate??? If not then go through this wonderful case by King @kis_lorand

Remember that ejac duct is INTRAprostatic➡️despite similar🔬histology to seminal vesicle, invasive tumor around ejac duct is NOT pT3b #GUpath #prostatepath

#prostatebiopsy treatment induced neuroendocrine differentiation following ADT and docetaxel therapy #gupath #prostatepath 📄 pubmed.ncbi.nlm.nih.gov/2470… 📄nature.com/articles/modpatho… 📄pubmed.ncbi.nlm.nih.gov/3264… 📄pubmed.ncbi.nlm.nih.gov/2688…

#prostatepath #GUpath a unique cohort of prostatic amyloid onlinelibrary.wiley.com/doi/…

#pathtwitter #GUpath #prostatepath #pathology #prostatecancer

So, Calling all #uropath's on #pathtwitter- Would you call this acinar and ductal on bx? Or acinar and PIN? Or just acinar? #GUpath #pathology #prostatepath

#prostatebiopsy History of low volume Gleason score 6 (3 3). Stain or not to stain? 🧐 #gupath #prostatepath