#DailyUltrasoundCase
☢️ HIV-Associated Nephropathy (HIVAN)
⏩️ Definition
HIV-associated nephropathy (HIVAN) is a collapsing form of focal segmental glomerulosclerosis in patients with HIV. It leads to rapid progression to ESRD due to direct infection of renal epithelial cells. Pathology shows glomerular collapse, microcystic tubular dilatation, and interstitial inflammation. It is common in sub-Saharan Africa where HIV prevalence is high.
⏩️ Symptoms
Heavy proteinuria with rapid renal function decline
Microscopic or gross hematuria
Hypertension and peripheral edema
Often in advanced HIV, but may appear earlier
Systemic HIV-related symptoms: fatigue, weight loss
Severe disease: uremic symptoms (nausea, confusion, pruritus)
⏩️ Risk Factors / Etiology
Cause: HIV infection with viral gene expression in renal cells
Demographics: Strong link to Black African ancestry (APOL1 variants); higher burden in sub-Saharan Africa
Disease Stage: Advanced or untreated HIV (low CD4); may occur in acute infection
Other: Co-infections (hepatitis), malnutrition, delayed ART
☢️ Sonographic Features
Bilaterally enlarged kidneys (>12–13 cm)
Diffusely hyperechoic parenchyma, loss of corticomedullary differentiation
Decreased/absent sinus fat echogenicity (renal edema)
Late stage: small, shrunken kidneys with cortical thinning (ESRD)
Doppler: Normal or reduced renal blood flow