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📄 A simple handgrip test GLS… could this change how we detect ischemia? 🔗 doi.org/10.1093/ehjimp/qyag0… 🫀 In patients with chronic coronary syndrome (CCS), choosing the right non-invasive test remains a major challenge. 👉 What if we could: ✔ Avoid pharmacological stress ✔ Use a simple bedside tool ✔ Still achieve high diagnostic accuracy? ✨ This study introduces a novel concept: 👉 Dynamic GLS assessment during isometric handgrip exercise 🔬 Study design: 👥 106 patients with intermediate coronary lesions 📊 Comparison with gold standard: FFR ≤ 0.80 🧪 Protocol: Rest echocardiography (rGLS) 3-minute handgrip stress Stress GLS (sGLS) Calculate ΔGLS (change with stress) 📈 Key findings: 🔥 ΔGLS showed strong correlation with FFR ➡️ r = 0.66 (p < 0.001) 🚀 Excellent diagnostic performance: ✔ AUC: 0.896 ✔ Sensitivity: 92% ✔ Specificity: 85% 👉 Optimal cut-off: ΔGLS = 0.35 🧠 Why this matters: ❌ Rest GLS alone → not enough ❌ Standard echo → no difference between groups ✅ Dynamic change (ΔGLS) → key discriminator 👉 Ischemic myocardium: ➡️ Fails to improve (or worsens) under stress 📊 As shown in the correlation plots (page 6): ✔ Strong relationship between stress GLS and FFR ✔ Even stronger for ΔGLS 🚀 Clinical implications: 👉 A potential game-changer for CCS evaluation ✔ Simple ✔ Low-cost ✔ No drugs ✔ Widely accessible 💡 Especially useful when: ➡️ Pharmacological stress is contraindicated ➡️ Resources are limited ⚠️ Limitations: ❗ Single-centre ❗ Proof-of-concept ❗ Needs larger validation 🚨 Take-home message: It’s not GLS at rest—but how GLS changes under stress—that reveals functionally significant coronary disease. #Cardiology #Echocardiography #GLS #CoronaryArteryDisease #Ischemia #CardiacImaging #StressEcho #Innovation #MedTech 🫀📊
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PC matchmaking finally broke me. I’ve been on PC for years, but the cheater situation in PvP many of the PC Extraction shooters and FPS games in general is an ongoing battle of frustration for most Between family life, streaming, and content creation, my time is limited. Wasting hours of trying to get some awesome rounds which end up ruined by rage-hackers just ain't fun. Having this issue with GZW was why I recently stopped playing it as I was literally getting Targeted by rage hackers who would call out my name when I have streamer mode on and even not streaming LOL. DMZ/COD in general is know for having ongoing issues with cheaters So recently I picked up a PS5 Pro. Honestly? I'm blown away by how good it feels. Booting up DMZ with crossplay turned OFF has made the game actually feel fair again. Sure, the one-shot shotguns and RGLs are a pain, but at least that's a balance issue and not someone running Walls or aimbot etc I’m officially making the move over to the PS5 Pro for DMZ and DMZ 2. I have best of both worlds, I can play crossplay with my PC mates and when doing solo stuff, just turn off crossplay. Less frustrating deaths and easier time getting content recorded :-)
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I need some earth shattering rgls angst rn I'm being sooo fr (listening to the sayonara mataitsuka cover)
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報告する程の事ではありませんが、今更ながら『催眠RGLS』を今日観たんですッ そこには可能性が広がっていました、 てぇてぇの、可能性が……ッ!!(瀕4) てか🎹ちゃん何シャッチョの事舐めとんねんワンちゃんかよいくら催眠にかかってるからっt――(*°ㅁ°)ハッ‼ 犬猫化したRGLSを飼育……ッ? 🚓=3
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rgls・GBハート
レグルシュ・金ビキニハート
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Yall, I have cracked the Cole Tomas Allen case, allegedly, pls don’t sue me (That MFer has 3 first names, there’s your first red flag). Now, please ignore the offensive globe because we all know the earth is flat. No, I don’t have any proof, so don’t ask me any stupid fking questions, Susan. Ok, so Israel, that little dreidel looking ass country across the Atlantic that is suspiciously close to the booty hole of the earth is using RGL’s to carry out these staged, yet real assassin attempts. If you don’t know what RGL’s are, please pay close attention. They are retarded gay lasers that Israel has placed on the satellites in the firmament because space isn’t real. Now, these RGLs are aimed at the U.S. in the attempt to ping the retarded gays, dialing em up like a Jewish neuro link to carry out Israel’s bidding. On this last assassination attempt, Israel chose to point all these retarded gay lasers at California because we all know that is the gayest fking state in these United States & the chances of tapping a gay there are 100% in any given GPS coordinate direction. And that’s when they pinged Cole Tomas Allen, the retarded gay engineer - jackpot. Now as a PSA, if you are not retarded or gay, these lasers will not affect you so there is no need to panic and go by 5,000 rolls of toilet paper. Don’t be a fking retard or the lasers will get you. And, no, that one lesbian experience I had in college does not count. Literally, everyone fking does that, Netanyahu, don’t come for me. Your retarded gay lasers will not work on me. Now stay tuned for part two as I divulge all the ways in which these retarded gay lasers are being used all across these United States to control the pronoun posse. That’s why they are so retarded and violent. *shakes fists in the air, cursing the Jews
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これ紫ノーツ追加されれば実質rglsでは?
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SSで出したことあるhlmnリスト 0:⚒☄️🌸(🤖pixivのみ) 1:🌽 2:🚑😈 gmz:全員 3:いない 4:️👾💫🐑 5:🎪♌️ 6:全員 rgls:🐧🎹🐚 flgl:💬 en:🎲🪶 id:いない 今後出すことが確定しているhlmn ☃️ 出したいなと思っているhlmn enいっぱい
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rglsが⚒️🍃に懐いてるの本当に最高ですよね…… 🎹✨🐧⚡️は⚒️🍃の子供だし…最近は特に🌃が……
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日曜日とても創作したいので、このツイートにみたいCPをリプください! 出来れば⚒☄️🌸gmz🍃🎣🧪rglsあたりから選んでもらえると助かりますが、頑張れそうなら他のCPにも挑戦しようかなと思いますので💪 ※伏字必須! ※CPのみ。シチュまで指定されると書けなくなっちゃうので…
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#wktk祭DX4 お疲れ様でした✨ #wktkくろわっさん で🌃でした💖 rglsちゃんのパフォーマンスはいかがでしたか?!! 楽しんで貰えてたら嬉しいです💕 もうずっと、一日中楽しすぎた🤣🫶 ありがとうございました(͒ ⸝⸝•̥𖥦•̥⸝⸝)͒❤︎ #ゆきねの夢
#wktk祭DX4 ありがとうございました!! #wktkくろわっさん でした🥐 ホロやリグロス初めて見たーって方たちからも、たくさん感想もらえて嬉しかったです♡リグロスはいいぞ...!!! わたしたちのステージを観てくださってありがとうございました✨✨
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Replying to @BioTechTraderSD
I still maintain the $RGLS theory here as well. This will go to $30 on a buyout/PIPE/or partner deal. No brainer here. Up 67% since the fake data dump on good data. Still 35k shares strong haven't sold a single share :)
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$RLYB - The parabolic move continues. Another $3 of free upside to get to cash value. What really will be fun is the value of RLYB116. Biogen paid $70 million upfront for a preclinical C5aR1 in October. $RGLS was bought out 4 weeks after their Phase 1 CKD data.
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this is only the beginning. Following the likeness of $RGLS . Data dump. No stock reaction. Buying pressure for 2 weeks afterward. M&A and/or PIPE
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鍋の具材よそいたいけど手が短くて届かない🐧の為にお皿どんどん盛り付けてあげるrglsメンバーくれ
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……犬化したバンチョか(ボソッ) ……知能や理性がワンちゃん化したバンチョ……RGLSで囲う……kyちゃんの薬由来なら他期との絡みも……(妄言)
わんこたんの真似がいつでもできるばんちょー #はじめ武勇伝
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『生んでにゃーよッ!!』 🌃🎹🐚🐧(RGLS) #物語の欠片の備忘録 🌃「……今hjmと結婚すればkndも手に入るのでは?」 🐚「うん、一旦落ち着こか?」
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$MREO : $RGLS -sold a P3 ready drug for Kidney disease for $700m plus a $700m CVR if their kidney drug gets approved. Total $1.4B. Setru would fit that mold. This puts price at $9.00 per share. It all depends on what Alvelstat is worth also. Street values it at $0.00 until deal
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Replying to @bioinvestor24
Thank you for letting me know that $NVS bought out $RGLS
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