Optimizing the integration of #RandomizedTrial #RCT and observational studies of interventions in #SystematicReviews and health #guidelines can be challenging. This #GRADE guidance tells you how. pubmed.ncbi.nlm.nih.gov/3480…

Mirtazapine or ondansetron for hyperemesis gravidarum: a randomized placebo-controlled trial ajog.org/article/S0002-9378(… #ClinicalTrial #HyperemesisGravidarum #Mirtazapine #RandomizedTrial #PregnancyResearch

📢 New publication alert New evidence from a RCT challenges a deeply entrenched practice in #LMIC surgery For clean thyroid and breast surgery, extending antibiotics after the single pre-incision dose did not reduce surgical site infections — even in a resource-constrained setting ✅ Safe ✅ Evidence-based ✅ Better antimicrobial stewardship Sometimes, doing less is doing better Great work by our young team led by @drskyind 🔗doi.org/10.1177/004947552614… #ThyroidSurgery #BreastSurgery #AntimicrobialStewardship #SurgicalInfections #GlobalSurgery #EvidenceBasedMedicine #RandomizedTrial #SSI

In healthy adults, a modified RNA vs. inactivated influenza vaccine reduced laboratory-confirmed influenza-like illness at ≥14 d 健康な成人で、核酸修飾mRNAインフルエンザワクチンが不活化ワクチンより検査で確認されたインフルエンザ様症状を減らした 米国、南アフリカ、フィリピンの248施設で行われた大規模な二重盲検ランダム化試験で、核酸修飾mRNAを用いた新しい4価インフルエンザワクチンと、標準的な不活化4価ワクチンを、18〜64歳の健康または安定した成人18,476人で比較した。 接種14日以降、検査で確認されたインフルエンザ様症状はmRNA群0.63%、標準群0.95%で、相対的な有効性は35%だった。 重篤な有害事象はまれで同程度で、心筋炎や心膜炎の確認例はなかった。 一方、発熱、筋肉痛、倦怠感はmRNAワクチンで多かった。 多くの症例はA型で、B型への効果は不確実。 In a blinded trial of 18,476 adults (18–64), a quadrivalent nucleoside-modified mRNA flu vaccine beat a standard inactivated vaccine during 2022–23. From day 14, lab-confirmed flu-like illness was 0.63% vs 0.95% (35% relative efficacy). No myocarditis was confirmed, but influenza B protection is uncertain. acpjournals.org/doi/10.7326/… #インフルエンザワクチン #mRNAワクチン #ランダム化試験 #influenzaVaccine #mRNAVaccine #randomizedTrial

Compelling evidence from a #RandomizedTrial (#RCT) looking at #PatientImportantOutcomes (#PROMS): 7-point scales and #VisualAnalogueScales (#VAS) show similar validity and responsiveness (sensitivity to change) to detect intervention effects. Either choice is fine. pubmed.ncbi.nlm.nih.gov/2157…

Tecovirimat for the Treatment of Mpox テコビリマットはクレードIIエムポックスの回復を早めず：国際第3相試験 7か国49施設で行った第3相二重盲検試験で、成人412人をテコビリマット内服（14日間）かプラセボに2:1で無作為化した。 検査でクレードIIエムポックスと確認され、活動性病変がある336人を主要解析に含めた。 29日目までの臨床的治癒はテコビリマット83%、プラセボ84%で差はなく（ハザード比0.98）、痛みの改善、病変の完全治癒、ウイルスDNAの消失も同程度だった。 重い有害事象はまれで、グレード3以上は4%対3%、死亡はなかった。 研究者は臨床的利益を示せなかったと結論づけた。 In an international, placebo-controlled phase 3 trial in adults with clade II mpox, tecovirimat did not speed clinical resolution: 83% resolved by day 29 on tecovirimat vs 84% on placebo (HR 0.98). Pain, lesion healing, and viral DNA clearance were similar, with few serious adverse events and no deaths overall. nejm.org/doi/full/10.1056/NE… #エムポックス #テコビリマット #無作為化比較試験 #mpox #tecovirimat #randomizedtrial

JMIR Formative Res: Automated Feedback After Internet-Based Depression Screening: Cost-Effectiveness Analysis of a Randomized Controlled Trial dlvr.it/TPzQgn #MentalHealth #DepressionScreening #AutomatedFeedback #CostEffectiveness #RandomizedTrial

Just published big news for #IntensiveCare. #RandomizedTrial demonstrates that a #ProtonPumpInhibitor not only decreases gastrointestinal #bleeding, but because of #costs generated by those bleeds also appreciably decreases #ICU costs. jamanetwork.com/journals/jam…

Anyone interested in determining the effect of a drug in a single patient by conducting a #RandomizedTrial in a that patient – an N of 1 trial – will find this step-by-step guide enormously useful. cmaj.ca/content/139/6/497

The ground-breaking @NEJM #randomizedTrial suggests that every #surgery patient at substantial #bleeding risk should receive #tranexamicAcid: 24% #RelativeRisk reduction in serious bleeding. nejm.org/doi/full/10.1056/NE…

Melasma Treatment Advances: Non-Ablative Laser and Tranexamic Acid Combination Explained @Amirhossein_RHN hemostasistoday.com/science/… #AITools #ArtificialIntelligence #Dermatology #Helath #Hematology #Hemostasis #HemostasisToday #Medicine #Melasma #NAFL #NonAblativeFractionalLaser #NonAblativeLaser #RandomizedTrial #Skin #Thrombosis #TranexamicAcid #MedEd #MedX

📌#RandomizedTrial 👉 #Cryoballoon non⬇️to #radiofrequency #ablation in persistent AF #EPeeps #WomeninEP #afib #CardioTwitter #MedTwitter @PrashSanders @Dominik_Linz @ManlioMarquez @yolyabreuh @DrJasonAndrade @DhirajGuptaBHRS @jacabreracardio @ALFIEEP1 @tomdepotter @EduardoSaad3

🍼 In a 90-day #RCT, toddlers fed formula without A1 β-casein had shorter respiratory infection duration & fewer GI symptoms vs conventional formula. No difference in ARI/diarrhea incidence. #pediatrics #pedsgi #openaccess #randomizedtrial 🔗 doi.org/10.1002/jpn3.12473?u…

Dear JMs, please have a look at this #article comparing the use of prednisolone and antihistamines for allergic #rhinitis, published in the #CTA_Journal by Skröder et al. In the link below! #EAACI #allergy #rhinitis #randomizedtrial 🔗 doi.org/10.1002/clt2.70017

Excited to share our latest #publication! 🎉 We conducted a #randomizedtrial on ICG-fluorescein cholangiography, comparing doses and timing in #LapChole. Huge thanks to all collaborators! 🙌✨

1/x #QFR did not meet non-inferiority to FFR in the @FAVORIIITrial Europe presented by @B_Krogsgaard The 1-year primary EP of death, MI, and unplanned revasc was 6.7% vs 4.2% in favour of FFR. 21% more study-lesions were treated- and 27% more stents were implanted with QFR due to a lower median QFR of 0.81 vs 0.84 for FFR. Published online in The Lancet. @h_evald @WestraJelmer @DrKoltowski @Eric_Van_Belle @GianlucaCampo78 @SimoneBiscaglia @ThueOlsen @AshkanEftekhar1 @ignamatsant @BarbaraStahli @ramonlopezpalop @HelleBargsteen @JEscaned @mirvatalasnag @mmamas1973 @HernanDMejiaR #TCT2024 #cardiotwitter #randomizedtrial

@TCTMD Interview with @B_Krogsgaard @wfearonmd and @mmamas1973 on the @FAVORIIITrial - LBT presentation #TCT2024 Wednesday at 11:47 EST - Details in the simultaneous publication #coronaryphysiology #randomizedtrial #cardiotwitter

Toto Centre is putting #LamuCounty on the global map. Among the 9 countries currently implementing the @TheKidsTrial project, Kenya leads with the highest number of children enrolled worldwide. #CoCreatedWithKids #RandomizedTrial #InnovatingWithKids

A #randomizedtrial shows no difference in hospital length of stay or cytokine levels between very early (<24h) and early (>24h) refeeding in #children with mild acute #pancreatitis. #Pediatrics #Nutrition onlinelibrary.wiley.com/doi/… onlinelibrary.wiley.com/doi/…

Prof Nicolas Meneveau announces the global #PERSEVERE RCT for acute high-risk PE in a full room at #ESCCongress. "PERSEVERE is the first RCT in high-risk PE in 40 years" #FlowTriever #PulmonaryEmbolism #RandomizedTrial #DataMatters #GoldenAge @jaygirimd @JonnyMoriarty @escardio