ALPHAFOLD: Five years of impact; Since 2020, #AlphaFold has accelerated the pace of science and fueled a global wave of #BiologicalDiscovery — an achievement recognized with a #NobelPrize. Five years ago, #AlphaFold2 solved the #ProteinStructurePrediction problem, unlocking new avenues of biological research and providing our first major proof point that #AI can be a powerful tool to advance science. #AlphaFold3, was then developed with #IsomorphicLabs, which offers an unprecedented view into cells that we expect to drive a transformation of the #DrugDiscovery process and usher in an era of "#DigitalBiology." The model is designed to predict the structure and interactions of all of #LifeMolecules — not just #Proteins, but #DNA, #RNA & #Ligands (the small molecules that make up most drugs). It can also generate the joint #3D-Structures of-#EntireMolecularComplexes, allowing a holistic view of how a potential #DrugMolecule binds to its #TargetProtein, or how proteins interact with #GeneticMaterial. (#DemisHassabis, #JohnJumper, #PushmeetKohli and #AnnaKoivuniemi on behalf of the #AlphaFoldTeam.) deepmind.google/blog/alphafo…

#TARGETProtein trial al centro del nostro prossimo Journal Club! 📆 Domattina, mercoledì 18 giugno | ore 07:00 CEST 📣 Dose proteica aumentata vs. standard in Pazienti Critici - da poco presentato a #CCR25 e pubblicato su @JAMA_current DM per il link Microsoft Teams📹 🇮🇹

Presented today at #CCR25 in Belfast, the #TARGETProtein trial provided a new piece of evidence for nutrition in critically ill patients. 💥 Looking forward to see how this trial will affect clinical practice and guidelines @CritCareReviews @ESPENorg @JAMA_current

First trial presented as part of #CCR25 #TARGETPROTEIN No difference in number of days free of the index hospital and alive at day 90

#CCR25 opens with the #TARGETprotein results Is additional protein beneficial in the critically ill? Join @LSChapple @msummo2 & @MelbourneICU to find out Editorial - Angelique de Man Panel - @Zudin_P @StephptaylorCLT & Monica Taljaard Register at criticalcarereviews.com/meet…

✨Interesting Research published in @JINeuroscience "MiRNA-1976 Regulates the Apoptosis of Dopaminergic Neurons by Targeting the PINK1 Gene". #Parkinson #PINK1 #TargetProtein #DopaminergicNeuron #apoptosis Read More:👇 imrpress.com/journal/JIN/22/…

Das Problem ist, dass nur ca. 20% das Targetprotein haben. Bei denen funktioniert es aber anscheinend zT ganz gut.

New #bioinfonotes about Membrane Blocking has been published ! #science #biology #membrane #detectormolecule #antibody #targetprotein #blocking #antigen #biologynotes

Dear Colleagues and Friends, I am pleased to announce the RT in @FrontPharmacol - Ethnopharmacology on "The Role of Natural Products in Chronic Inflammation". frontiersin.org/research-top… #inflammation #antiinflammatoryactivity #signalpathway #targetprotein #INPST #NPMND #DHPSP

There may be some arguments between us about which is the best study... Clearly it’s #TARGETPROTEIN but @TAMEtrial ain’t too bad 😜

Thanksfully this is one aspect we don’t need to consider for #TARGETProtein!

This thread of some great work shows higher protein may improve N balance in critically ill pts, and there are ways to deliver more protein enterally; but is this feasible across multiple sites and will more protein improve clinical and functional outcomes? #TARGETProtein

Looking forward to more work in this area @LSChapple @ICUnutrition @ProteinTarget #TARGETprotein

Prof Biolo on what we know about protein metabolism in ICU. RCTs on protein delivery required. Time for #TARGETprotein #ESPEN2018

Food Blog bit.ly/2CrYJtP Directory List @AndrewHanna @deliciousnsusty @Cookmenu1 @TargetProtein #cooking #recipe #foodie #foodporn #foodblogger #marketing

We hope you are having a great week, Allison!

Thank you! Right back at ya!

#FF @SneaksOnFiree @fitnssland @BearStrength @fitnsgift @ZestHomeFitness @MMFitness_IE @SabaiDeeCBD @fitnesempire @OrganicVirals @imwtclothing @TargetProtein @copmasterovic @EnfieldBusiness @fitnesin @classymommy @AidenHatfield @RevereSport have a great #StPatricksDay weekend!

How many 🍻 beers does that equate to ❓

Hi @TargetProtein , thanks for the follow! Have a great day!.