New proteomic clock predicts biological age and major health risks across diverse populations 🚀🧬📊 news-medical.net/news/202408… #Proteomics #BiologicalAge #Aging #Health #ChronicDiseases #Mortality #PlasmaProteins #AgeClock #Omics @NatureMedicine

Your Telomeres are getting shorter or you're wondering how long/short they are, and what could be the impact on your biological age ? Here is what you should know 👇 🧬 What are Telomeres ? Telomeres are repetitive DNA structures located at the ends of our chromosomes. They act as protective caps of our genetic material, similar to the plastic tips at the ends of shoelaces. They safeguard our chromosomes from unraveling or fusing with neighboring DNA strands. 🧬 The Role of Telomeres in Aging With each cell division, these protective caps naturally erode, gradually becoming shorter. This process is known as telomere shortening. Telomeres serve as a clock, counting down the number of divisions a cell can undergo before it reaches senescence, or a state of irreversible growth arrest. When telomeres reach critically short lengths, they send signals to the cell, triggering a shutdown of the replication process. This mechanism serves as a protective measure, preventing cells from becoming dysfunctional or potentially cancerous. 🧬 Telomeres and Biological Age Telomere length provides a valuable new marker for biological age, offering insights into our overall health and susceptibility to age-related diseases. As the field of telomere research continues to advance, we may witness groundbreaking discoveries that further unravel the mysteries of aging and open new doors for improving human health and longevity. 🧬 Companies Offering Telomere Length Testing ▫️ TruDiagnostic (affiliate): Provides a test that can determine the average telomere length, measured with methylation, the telomere age and the telomere status compared against the average population trudiagnostic.pxf.io/Lifespa… @TruDiagnostic ▫️ Life Length: Uses HT Q-FISH (High-Throughput Quantitative Fluorescence In situ Hybridization) methodology. It measures over 100,000 individual telomeres, chromosome-by-chromosome in tens of thousands of cells. lifelength.com/en/telomere-l… @LifeLength ▫️ Repeat Diagnostics: Uses FlowFISH (fluorescent in-situ hybridization) methodology. It assesses fluorescent signals from telomeres on a single cell basis. repeatdx.com/ @RepeatDx ▫️ SpectraCell Laboratories: Provides a Telomere Test that can determine the length of a patient’s telomeres in relation to their age. spectracell.com/telomere-tes… @SpectraCellLab Also, something to keep in mind as recent studies have suggested that telomere length alone may not be a reliable predictor of lifespan or aging. For example, some individuals with shorter telomeres have been found to live longer than those with longer telomeres. medicalnewstoday.com/article… nih.gov/news-events/nih-rese… Other indicators such as certain immune parameters and indices of epigenetic age could be stronger predictors of health status and risk of chronic disease. frontiersin.org/articles/10.… However, despite these issues and limitations, telomere length remains to be very informative marker in accessing the biological age when used along with other markers such as indices of homeostatic dysregulation, frailty index, epigenetic clock, etc. link.springer.com/article/10… #LONGEVITY #CellsDivision #antiaging #Telomeres #epigenetics #ageclock #BiologicalAge #DrSinclair

经 @roczhang9673 提醒 原来 AgeClock Catalyst 版也上 Mac App Store 首页故事了！

抽出了点时间给大二时做的俩 app 更新了下 老了真的熬不动了（ 想要测试 AgeClock 新版的可以点 testflight.apple.com/join/Gm… 加入，目前 watchOS 的部分因为在重写所以还没表盘可以用，但挂件生产工作，也没有一行 ObjC 在里面了

Fantastic weekend at #CSF2019 with the #AgeClock team - thanks to everyone involved and to @camscience for hosting. We hope you enjoyed it as much as we did!