Heat intolerance in the ‘agitated’ hypothyroid patient...
“A 64-year-old woman was initially seen complaining of notable intolerance to hot weather, nervousness, emotional irritability, crying spells, and insomnia. She had been treated intermittently for a thyroid disorder with desiccated thyroid, 130 mg/day, for 30 years. She had finished the thyroid tablets eight weeks earlier while attending her sister's funeral...
Levothyroxine sodium administration, 25 ug/day, was begun during the initial two weeks and was increased by 25 mg/day every two to three weeks... By the fourth month of therapy, then receiving levothyroxine sodium, 100 ug/day, she felt well. The depression, nervousness, and irritability had disappeared...
She may be considered the "agitated" hypothyroid counterpart of the "apathetic" hyperthyroid state.”
Ray Peat was asked about this on a radio call-in show.
“I’m on PubMed, where they did a study about hypothyroidism, heat intolerance, and anxiety. And I ask because I have that, and I've never heard about it before. And I wondered if Dr. Heat had anything to say about that. Because I do wake up with a low temperature in the morning, but I'm very sensitive to heat and I become overheated very quickly.
[Ray] Have you checked your temperature during the times when you're feeling overheated?
Yeah, it usually doesn't seem that high. I mean, it's never usually more than 99.
[Ray] If you're really hypothyroid and have, say, a 97-degree temperature when you wake up, it's important to keep taking your temperature and pulse rate during the day to see what the effect of food and activity is on both your temperature and pulse rate. Lots of people who have discomfort in the heat have very high nitric oxide production, which causes vasodilation and reddening of the skin, but that lowers core temperature. So to understand what's happening metabolically, you should check your temperature before and after those experiences of heat intolerance.”
Ref: Agitation and Heat Intolerance in Hypothyroidism