My favorite land animal is actually a nope rope. The bottlenose dolphin is my favorite ocean animal. This nope rope is the deadliest land animal but not as aggressive as its coastal relative. They are the ultimate introvert and live in environments inhospitable to humans. I admire that. The inland taipan is living the dream. #ILoveScience #ILoveAnimals billabongsanctuary.com.au/in…

Perché in alcune specie animali le femmine mangiano i maschi? Ecco la possibile spiegazione. tonykospan21.wordpress.com/2… #ilovescience @SalaLettura #nature #VentagliDiParole

A shit tonne. And it's amazing 🤩 #ilovescience

Nell'anniversario della nascita del grande botanico Linneo un accenno alla sua mitica Meridiana dei fiori cioè un orologio fatto tutto di fiori tonykospan21.wordpress.com/2… #23maggio #ilovescience #VentagliDiParole @SalaLettura

ayo jimin wanna talk about science? #stemgirlie #ilovescience

Un buco nero Eccolo fotografato per la prima volta al centro della nostra Galassia, la Via Lattea. La storia e le immmagini tonykospan21.wordpress.com/2… #ilovescience #scritturebrevi #SalaLettura #VentagliDiParole

ABC countdown @MRobinsonElem @MrsAngelClass celebrating the letter R. Rainbow 🌈 day with my amazing first graders. #kidsdeserveit #ilovescience #cfisdprimary #igniteaspark

Génial : ça m'évitera à l'avenir d'avoir une piqure dans chaque bras 😅 ! #ILoveScience

@MrsAngelClass Celebrating Earth Day 🌎 @MRobinsonElem #igniteaspark #kidsdeserveit #ilovescience #cfisdprimary

scoby is sooo crazy to look at like that’s literally tea placenta…… like that’s literally mother….. #ilovescience and #ilovekombucha

@MrsAngelClass explored different types of soil @MRobinsonElem with Ms.Ahmed in the science lab through hands-on investigation. #igniteaspark #kidsdeserveit #cfisdprimary #ilovescience

soil investigation @MrsAngelClass @MRobinsonElem My students had so much fun!!#kiddeserveit #igniteaspark #cfisdprimary #ilovescience

I had a fantastic meeting with my colleague, Dr. Pritam Ganguly, from the @RITscience Science School of Chemistry and Materials Science, about a potential collaboration using computational chemistry to explore antimicrobial peptides as targets for antibiotic development. As we talked, we revisited a JBC study on diaminopimelate decarboxylase, the enzyme that catalyzes the final step in lysine biosynthesis via the diaminopimelate (DAP) pathways, converting meso-diaminopimelate (m-DAP) into lysine that was published in JBC: sciencedirect.com/science/ar… What makes this pathway particularly compelling is that m-DAP serves a dual role in Gram-negative bacteria. It is not only a precursor for lysine for protein synthesis, but also the key cross-linking amino acid in peptidoglycan. That discussion immediately brought me back to a functional complementation experiment we conducted for the study with my former student, Mary Leeman, MD. We employed the E. coli lysA mutant, which is auxotrophic for lysine, meaning it cannot grow unless lysine is supplied in the media or the pathway is restored via a functional gene. We introduced the two LysA orthologs from Arabidopsis thaliana under an inducible system: expression is turned on with arabinose and repressed with glucose, using an empty vector as a control in the lysA mutant. Early on, the results were baffling. We observed growth on lysine-free media in the presence of glucose, but no growth when arabinose was added, the exact opposite of what we expected. We repeated the experiments many times, remade media, checked plasmids, and questioned every variable possible. I remember thinking about this day and night, and then it clicked one day driving home! Under arabinose induction, the enzyme was highly expressed, rapidly converting m-DAP to lysine. While lysine was being produced, the cell was effectively depleted of m-DAP needed for peptidoglycan cross-linking, compromising the cell wall and preventing growth. Under glucose repression, however, expression was low but slightly leaky, just enough to produce lysine while still preserving sufficient m-DAP for cell wall biosynthesis. Growth, it turned out, depended not on maximizing enzyme expression, but on maintaining metabolic balance. Moments like that capture the joy of science. What initially seems perplexing often reveals something deeper if you stay with it long enough. Sometimes the breakthrough comes not at the bench, but in reflection. #ILOVESCIENCE

You’re too kind. I want to call it ‘tardsophy. Oh well. Accounts like that, and ILoveScience, exist.

Guys I’ve got a confession.. I’m the real Szayelaporro Granz posing as a teenage girl on the internet..😔 #Ilovescience #SzayelaporroGranz #therealme #science

Wow! Incredible! #ILoveScience

La caduta di un meteorite sulla Terra Le rare immagini dalla caduta fino al suo recupero tonykospan21.wordpress.com/2… #unTemaAlGiorno #ilovescience #scritturebrevi #SalaLettura

Vous serez un jour tenue pour responsable, la majorité des Français finira par comprendre vos manipulations éhontées qui se retournent contre eux, @GabrielleCthl de la #LFI. #ILoveScience #SoutienAuxAgriculteurs contre les pourris menteurs escrologistes/décroissants pro-chaos..

Et vous avez bien raison. #ILoveScience #AFIS

Scrappy.xn--psd WELCOME TO THE HOLLOWVERSE #ILOVESCIENCE #ILOVEVENNMORE