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We’re switching it up! Celebrate EAL’s new #MethodMonday by dancing around to your favorite songs! #loveyourbrain #EAA 💃🪩🕺
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#MethodMonday 49: GRADE in systematic reviews with meta-analyses and clinical practice guidelines 1) doi.org/10.1111/aas.14386 2) doi.org/10.1111/aas.14384 This week includes two papers on using the GRADE (@GRADE_WG) approach in SRMAs (#1) and clinical practice guidelines (#2) 1/...
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#MethodMonday 48: Estimating means/SDs from medians/IQRs/ranges? 1) doi.org/10.1186/1471-2288-14… 2) training.cochrane.org/handbo…, sections 6.5.2.9 10.5.3, 6.5.2.4-6 This week covers methods for estimating means and SDs from medians/IQRs/ranges, as frequently done in meta-analyses. 1/..
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#MethodMonday 47: Factorial trials doi.org/10.1186/1471-2288-3-… doi.org/10.1001/jama.2023.19… This week focuses on factorial trials, where participants are randomised to multiple 'sets' of interventions (factors), i.e. A vs B and C vs D, leading to combinations A C, A D, B C, and B D 1/..
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#MethodMonday 46: Analysing outcomes also measured at baseline in trials doi.org/10.1136/bmj.323.7321… This week's paper by @VickersBiostats and Altman discusses how outcomes measured both at follow-up but also at baseline in trials should be analysed 1/..

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#MethodMonday 45: 10 simple rules for good research practice doi.org/10.1371/journal.pcbi… This article follows #MethodMonday 44, and includes a checklist of 10 points covering the essentials for good research practice 1/..
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#MethodMonday 43: Directed acyclic graphs (DAGs) doi.org/10.1001/jama.2022.18… This week's paper is a brief introduction to DAGs. DAGs are used as a tool to specify analytical models in e.g. observational studies and a formalised approach to variable selection.. 1/..

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#MethodMonday 42: Immortal time bias catalogofbias.org/biases/imm… doi.org/10.1002/pds.1357 This week covers immortal time bias in observational studies - periods where participants in a cohort by definition cannot experience the event of interest. 1/...

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#MethodMonday 41: Environmental life cycle assessments doi.org/10.1097/ogx.00000000… This week's paper suggested by @TineMeyhoff - thanks! Suggestions always welcome. It covers life cycle assessments (LCAs), a method to quantify the enviromental impacts of medical practice 1/..

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#MethodMonday 40: Prospective meta-analyses doi.org/10.1136/bmj.l5342 This week's article concerns prospective meta-analyses (PMAs) - meta-analyses planned before the included studies are completed. It how PMAs differ from conventional systematic reviews with MAs, ... 1/...

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#MethodMonday #39: Cluster-randomised trials doi.org/10.1093/ije/dyad064 #MethodMonday is back after a break, this time with a paper on cluster RCTs. The article covers key methodological considerations, including the potential disadvantages of cluster trials 1/..
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👨‍🔬This #MethodMonday Lautaro Gándara and colleagues at the University of Buenos Aires reveal how to design FRET-based sensor experiments👩‍🔬 Read the full #OpenAccess🔓Methods & Techniques article here: journals.biologists.com/bio/…
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🧬🔬This #MethodMonday Katie M. Toperzer and colleagues @FloridaTech use a CaFE reporter, a calcium indicator which aids the visualisation of sperm-egg fusion during fertilisation. 🔓 Read the full #OpenAccess Research Article here: journals.biologists.com/bio/…
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🔬This #MethodMonday @StanStrawbridge and colleagues describe a new mathematical framework classifying interior and exterior points of imaged cells within the early mouse embryo. Read the full #OpenAccess Methods and Techniques article here: journals.biologists.com/bio/…
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#MethodMonday 38: Common statistical misinterpretations doi.org/10.1007/s10654-016-0… This paper by @Lester_Domes @stephensenn covers some of the most common misinterpretations of statistical tests, p-values, confidence intervals and power. 1/..

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#MethodMonday 37: Bayesian analyses doi.org/10.2196/10873 doi.org/10.1136/bmjopen-2018… These papers provide an introduction to Bayesian statistical methods and a comparison with conventional frequentist methods (incl. p-values, confidence intervals, null hypothesis tests) 1/..

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This #MethodMonday Tomohiro Tamari and colleagues @jacksonlab demonstrate that the zygote electroporation method is effective for generating knockout mice in multiple inbred strains. Read the full #OpenAccess Methods and Techniques article here: journals.biologists.com/bio/…
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#MethodMonday 36: Random forests nature.com/articles/nmeth.44… This paper covers ensemble methods, specifically bagging and random forests. In brief, these methods rely on using a simple regression tree to split the dataset... (1/...)
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#MethodMonday 35: Clustering doi.org/10.1038/nmeth.4299 Clustering methods may be used to find clusters of similar patients based on multiple variables. This paper introduces general principles, some specific methods, assessment of similarity within clusters (ideally high).. (1/..)

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