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Stanley E. Strawbridge @StanStrawbridge

Group Leader and Fellow in the Physics of Life & Quantitative Biology @sheffielduni. #StemCells #Development #Mathematics #MachineLearning . 🇺🇸🇬🇧

Joined June 2011
  • Tweets 496
  • Following 577
  • Followers 364
74 Photos and videos
🚨 New Preprint "Quantification and statistical comparison of cell-state transition kinetics using a parametric failure-based model" doi.org/10.64898/2026.04.21.… Cells do not usually change state at a single fixed time. How can we compare these distributions across conditions? 🧵1/3
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Stanley E. Strawbridge retweeted
David Turner@da40cambs
May 28
We're accepting self-funded PhD students to work on Wnt and Notch signalling using Gastruloids! Spread the word! liverpool.ac.uk/courses/mole…
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🚨 New Preprint "Quantification and statistical comparison of cell-state transition kinetics using a parametric failure-based model" doi.org/10.64898/2026.04.21.… Cells do not usually change state at a single fixed time. How can we compare these distributions across conditions? 🧵1/3
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We view cell-state transition as analogous to system failure & argue that kinetics are a phenotype. The model separates four features: onset delay, timescale, shape, and competent fraction. We apply it to pluripotency exit, directed differentiation, and reprogramming. 🧵2/3
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Thank you to: Co-author, @AlexGFletcher ; Host, @sheffielduni; Funder, @wellcometrust.
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⏰ Deadline Approaching! ⏰ 📅 15 January 2026 Under two weeks to apply for our fully funded PhD project “Engineering an in vitro human embryo implantation platform to study pathologies arising in early pregnancy” at @sheffielduni. #development #endometrium #materialsscience
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I strongly encourage ECRs to apply for opportunities like the Travelling Fellowships from the ever supportive @Co_Biologists. They are fantastic for learning new skills, building collaborative networks, and honing scientific writing. doi.org/10.1242/dev.205356

The Company of Biologists Travelling Fellowships programme: a commitment to support the next...

ABSTRACT. Between 2008 and 2025, four of The Company of Biologists' journals – Development, Journal of Cell Science (JCS), Journal of Experimental Biology (JEB) and Disease Models & Mechanisms (DMM)...

journals.biologists.com
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⏰ Deadline in two weeks! ⏰ Work at the interface of biology computation to build a virtual human embryo to predict developmental success and failure. Happy to answer questions!
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Stanley E. Strawbridge retweeted
Rory Cooper@rorylcooper
3 Nov 2025
🚨 Come join us @sheffielduni for a PhD on the evolution and development of feathers and flight! 🐣🔬 This project is supervised by @Mattowers1 @AlexGFletcher, and I'm excited to be involved as a project advisor. Please share! findaphd.com/phds/project/bb…
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🚨 PhD Projects 🚨 We are advertising two UKRI funded PhD projects at @sheffielduni through the @The_MRC with @AlexGFletcher and the @EPSRC with @emmafromthelab . #stemcells #development #embryology #reproductivephysiology #mathmaticalmodelling #quantitativebiology
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Stanley E. Strawbridge retweeted
Development@Dev_journal
26 Jun 2025
Embryonic chimeras: donors in, hosts out Read this Research Highlight showcasing work from @StanStrawbridge, @AlexGFletcher, Jennifer Nichols and colleagues (@SCICambridge @PDN_Cambridge @Cambridge_Uni @shefmathbio @sheffielduni @mrc_hgu @EdinburghUni): journals.biologists.com/dev/…
Figure 2 (B) Representative maximum intensity projections of confocal z-stacks for chimeras injected with ten Fgf4−/− ESCs showing high (Hi; n=24) or low (Lo; n=17) donor contribution, non-injected embryos (n=25) and ten Fgf4 / ESC-injected chimeras (n=34).

ALT Figure 2 (B) Representative maximum intensity projections of confocal z-stacks for chimeras injected with ten Fgf4−/− ESCs showing high (Hi; n=24) or low (Lo; n=17) donor contribution, non-injected embryos (n=25) and ten Fgf4 / ESC-injected chimeras (n=34).

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🚨 New paper out in Development! 🚨 We show that donor embryonic stem cells (ESCs) reshape the developing mouse embryo, not just by what they signal, but where they push. 📄 doi.org/10.1242/dev.204518 [1/8]
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Also, check out the behind-the-scenes interview on my path in science, a eureka moment, and what I do when I choose to leave the lab: 🎙️ doi.org/10.1242/dev.205019 [7/8]

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Finally, a career highlight, we made it into cellysally's #PaperThemeTune s: bsky.app/profile/cellysally.… [8/8]
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1/10🧵New preprint! 🚀 We built a resource of 20 clonal human naïve pluripotent stem cell lines from 10 blastocysts. Explore embryo-to-embryo and clone-to-clone variation in one place. 👉doi.org/10.1101/2025.06.02.6…
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9/10 @SCICambridge @PDN_Cambridge @BabrahamInst @CamBiochem @Cambridge_Uni @ScienceShef @sheffielduni @aberdeenuni @EdinUni_IGC @mrc_hgu @usponline @LSI_Exeter @UniofExeter
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10/10 Thanks to: @The_MRC @wellcometrust #SãoPauloResearchFoundation @jsps_sns #UEHARAMemorialFoundation
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