ALT Single-Cell Multiome allows for both transcriptome analysis and genome-wide detection of open chromatin at the single cell level. Understanding both the gene expression profile and the chromatin state at single-cell resolution can help identify how epigenetic changes instruct gene expression in distinct cell populations. What are the advantages of using Single-Cell Multiome? Single-Cell Multiome can be used to identify cell subpopulations with different transcriptome and epigenetic profiles within complex samples, eliminating the need for isolation strategies like FACS or magnetic sorting that could alter the biology due to sample manipulation. For example: Identifying novel cell that modulate response to drug treatments Identifying subpopulations of cells with variations in gene expression that can provide insight into developmental trajectories (i.e. brain development, T-helper cell development, B-cell differentiation) https://www.activemotif.com/catalog/1355/single-cell-multi
