describing pathologic classic to my coworker while working at a dessert shop had me lookin like

mwa ! #burakhovsky #pathologic

Quantitative Assessment of Discordance Rates Between Preoperative MRI Restaging and Postoperative Pathologic Reports in Patients Undergoing Rectal Resection Following Neoadjuvant Therapy – A Word of Caution Regarding Patient-Selection 🟢Free Access academic.oup.com/bjs/article…

🟡 JAUNDICE MADE SIMPLE A high-yield approach to jaundice that helps you diagnose the cause in seconds by combining bilirubin type, urine color, and stool color. ⸻ 1️⃣ Bilirubin Pathway ➊ RBC breakdown → Unconjugated bilirubin ➋ Liver conjugates bilirubin (UGT1A1) ➌ Conjugated bilirubin enters bile → intestine 💎 Pearl: Indirect = Water insoluble Direct = Water soluble ⸻ 2️⃣ Indirect (Unconjugated) Jaundice 🔴 Causes • Hemolysis • Gilbert syndrome • Crigler–Najjar syndrome 🔍 Features • Normal urine • Normal stool • No bilirubin in urine 💎 Remember: Indirect bilirubin is NOT found in urine. ⸻ 3️⃣ Direct (Obstructive) Jaundice 🟢 Causes • Gallstones • Pancreatic cancer • Cholangiocarcinoma • PSC 🔍 Features • Dark urine • Pale stools • Pruritus 💎 Exam Pearl: Dark urine Pale stool = Obstruction until proven otherwise. ⸻ 4️⃣ Hepatocellular Jaundice 🟠 Causes • Viral hepatitis • Alcoholic hepatitis • Drug-induced liver injury • Cirrhosis • NAFLD/NASH 🔍 Features • Mixed bilirubin elevation • AST/ALT ↑ • Jaundice RUQ pain 💎 Pearl: Very high AST/ALT suggests hepatocellular injury. ⸻ 5️⃣ Neonatal Jaundice 👶 Physiologic • Starts after 24 hours • Peaks day 3–5 • Resolves by 1–2 weeks 🚨 Pathologic • Within first 24 hours • Persists >2 weeks • Rapidly rising bilirubin 💎 Red Flag: Dark urine Pale stool = Think biliary atresia. ⸻ 🎯 Quick Exam Trick 🟡 Indirect → Normal urine Normal stool 🟢 Direct (Obstructive) → Dark urine Pale stool 🟠 Hepatocellular → Mixed pattern AST/ALT ↑ 👶 Neonatal → Check timing of onset ⸻ 📚 Master Gastroenterology & Hepatology the High-Yield Way with the MedicoNotes Gastroenterology Book. 🌐 Visit our website: mediconotes.com #Gastroenterology #Jaundice #Hepatology #MedicalEducation #MedicoNotes

my playstation home screen looks crazy... It's like every Resident Evil game and then Pathologic 3,

#pathologic Ева, я любила тебя 🦭

no è palese, dice cose assurde (persona inaccessibile perché su PlayStation??) e poi sotto cita Pathologic che è uno dei giochi più larpati del pianeta

#pathologic #морутопия

#pathologic #морутопия Я решила навалить кринжа