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Our first @DARPA program NODES is about to begin, come join us. Here is a glimpse of the broader vision. "A to-do list for realizing the sequence-to-function paradigm of proteins" #currentopinionsinstructuralbiology Despite AlphaFold's success, inferring function from sequence remains unsolved. This review lays out the roadmap to bridge this gap using: 🧠 Biophysical signatures 📉 Dimensionality reduction 🔬 Integrative modeling 💡 Machine learning beyond brute-force MD Key insight? We don’t need all dynamics — just the right representations. From MHC binding fingerprints to cell-scale simulations, this piece reframes the problem and offers a tractable path forward. 👉 Read more: sciencedirect.com/science/ar… Check out NODES - darpa.mil/research/programs/… 🔍 #proteindynamics #AIinBiology #computationalbiology #structuralbio
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I will be attending the International Conference on Electron Microscopy and the Annual Meeting of the Electron Microscope Society of India (EMSI, South Zone) held at IISc Bangalore from July 10-14. Excited to meet and interact with fellow enthusiasts! #CryoEM #StructuralBio
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Our MLTB Ep4= insights, information & inspiration! @Dr.Millot @SeoulNatlUni delivered an impactful session introducing tools🏎️ driving a revolution in #compbio simplifying complex #structuralbio probs with their high edge 🖥️⚙️ & trademark caricature🦊 🙏 Gratitude to 🌍audience!
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Check out this #OA research article, where Mazzone et al. present a crystal structure of the T. gondii DXR enzyme, complexed with an inhibitor and NADPH, and investigate analogues that can also act as DXR inhibitors. #Enzymes #StructuralBio doi.org/10.1042/BCJ20240110
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16 Oct 2024
Session 2 of #ASCS24 Pre-symposium Workshop with Dr.Preeti from @PDBeurope is live 🖥️💻. Join us as we dive in the structural world of Protein Data Bank and rob the treasure of knowledge with our amazing speaker and tutor. #proteindatabank #alphafold #structuralbio #compbio
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10 Jun 2024
We had an amazing Practical Crystallography Course at @MeharryMedical last week! Thanks to Kay, Frank, Cyndi frm NE-CAT @Advancedphoton and Jason from @SBGrid . We are excited to see what new structures are solved from this newly exposed cohort. hashtag#StructuralBio #HBCUs #MSIs
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30 Mar 2024
Great opportunity to join an amazing team with the one and only @NathanSinghLab! #CART #geneediting #structuralbio
Twitter fam! We are looking for a research associate to join our awesome team. If you know anyone interested in the interface of protein engineering, structural bio, gene editing and T cell immunotherapy please reach out! Also, please retweet and spread the word!
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Celebrating 50 Yrs of #Cell Press & #StructuralBio in India! Cell's special issue highlights the amazing progress of #cryoEM research in India! Huge shoutout to @sathi_iitdelhi facility & @Icosahedral16 for their contributions! Read more in Structure Vol. 32 (1): 1-2
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2 Nov 2023
Our first CryoEM Basics Workshop # 1 @SBGrid Consortium providing equitable access to #cryoEM resources through a (@NIGMS ) IPERT Grant! Thanks Jason Key for the tour. Several HBCU and MSI faculty represented. #BIBPS #HBCUs #MSIs #StructuralBio
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Hi StructuralBio folks, I had this version of Pymol that I really like. It has the draw and ray buttons fused and it opens this nice little menu with options I like for drawing and rendering. Does anyone know a plugin to give me this little menu in other Pymol versions?
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Very happy that @Rhys__G and I secured funding to engineer enzymes to create #biosensors for #precisionagriculture! Looking for #PhD and #Hons students with interest in #proteineng #structuralbio @monashengineers @Monash_Science @MonashBDI @MonashResearch
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I have tried many different programs to visualize proteins, make movies/illustrations etc. Which program is your favorite? Any advice for someone who is wanting to make dynamic, beautiful and interactive protein structures? #AcademicTwitter #StructuralBio #ScienceIsBeautiful

ALT Yoda Star Wars GIF

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Tremendous work by Angel D'Oliviera & @JeffMugridge on #TRMT1 & #SARSCoV2 Read🧵 preprint👇 Postdoc @mottasx1 & I @CIRI_Lyon are glad we could jump on some evolutionary fun w U, Jeff🙏 &play a tiny role in this great study #COVID #structuralBio #EvoForTheWin #RodentsWinThisTime
📢First preprint from our lab now out! 🥳 We show how the human tRNA-modifying enzyme TRMT1 is recognized & cleaved by the SARS-CoV-2 main protease. Congrats to Angel D'Oliviera who led this work and collaborators Yingkai Zhang & @Lucie_Virevolte! 🧵... biorxiv.org/content/10.1101/…
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Stop by Building & Leveraging Mentoring Networks to Support DEI in Cell Bio at #cellbio2022 Dec 6 1:45pm @jscdavis host discussion on using mentorship to build inclusive cultures @MeharryMedical #structuralbio #healthdisparities #genetics #Alzheimers #Meharry #BlackinBiophysics
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Going to #cellbio2022? Let’s talk diversity, equity, and inclusion in academia Dec 6th 11:15 am @jscdavis will help lead the discussion on being a good lab citizen. @MeharryMedical #structuralbio #healthdisparities #genetics #Alzheimers #Meharry #BlackinBiophysics
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11 Oct 2022
Up next in our IMPloyable talent series: Katarina Belačić, member of the @HaselbachLab, who will take on a job @valanxbio after her successful PhD in #structuralbio (@TrainingVbc). Read her story below 👇🏾 linkedin.com/pulse/imployabl… #leavingacademia #phdchat #academicchatter

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This is a spectacularly interesting piece of work combining #DevBio #StructuralBio and #EvoBio
Excited for the end of a long and winding road just published published -rdcu.be/cV8GO. Evolution of OCT4 and naïve/primed pluripotency. Protein evolution occuring via tweaks domain orientation rather than mutations in the domains themselves.
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We have added several exciting features to our tool iCn3D! Learn more here! 👇 ow.ly/EemA50K8Vf2 #AlphaFold #VR #AR #3DViz #StructuralBio
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