Most methods for measuring neurotransmitters are invasive. Fast-scan cyclic voltammetry, optogenetics, and two-photon methods often require electrodes, skull openings, or craniotomy-style access.
Other methods, like examining cerebral spinal fluid, aren’t accurately examining what’s happening in the CNS and that which is paracrine to the brain tissue.
This study asked a simple
question: can Raman-based spectroscopy read neurochemical signatures through bone?