Very happy our teams story (@Toker_IA @YaelMor3) is finally out! Even transient transgenerational effects can have an impact on evolutionary processes. great-grand progeny of stressed worms inherit the ability to produce male attracting odor, increasing their chances of mating.

For decades, two revolutions in neuroscience ran in parallel: - 🧠 In vivo imaging — watch neurons fire in living animals - 🧬 Spatial transcriptomics — read cell's molecular identity Meet TRU-FACT - a graph-based method that matches cells between these datasets at scale 🧵

High-resolution global recombination mapping in C. elegans reveals sexual dimorphisms shaped by meiotic chromosomal features and ... biorxiv.org/content/10.64898… #biorxiv_genetic

Important context for all the hype on the fly connectome brain simulation.

It’s finally out! Together with @EMBO and @ReviewCommons, we conducted a structured side-by-side comparison of human peer review and our AI scientific review. Here’s what we did: Authors whose manuscripts had already received journal-agnostic review at Review Commons were provided with an independent AI review generated by @qedScience. The AI analysis was compared to the combined feedback of multiple human reviewers, not to a single report, and had no access to those reviews. We then asked authors how they evaluate the strengths and limitations of both approaches, and how they would actually want to use AI. The conclusion was clear: Scientists want AI feedback to strengthen their work IN ADVANCE, under their control. Not as a gatekeeper, but as a tool for constructive input. That is exactly what we are building at q.e.d! We are on the authors' side. q.e.d. is not working in isolation; we are collaborating with leading pro-scientists organizations, including EMBO (and other journals), Review Commons, and OpenRxiv (@biorxivpreprint), and are working closely with researchers across fields. At the same time, we are building an alternative model that puts agency directly in scientists’ hands. Researchers should be the ones deciding when their work is ready to be shared. We are building the infrastructure to support that. A pleasure doing this with the great Thomas Lemberger @tlemberger and Niv Samuel Mastboim @nivmast

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has on the well-being of myself, my team, and pretty much every scientist I know (maybe you’ve noticed from my stupid jokes… :) I was exhausted of dealing with the huge delays, reviewers that can be abusive, and how arbitrary it all is. Unfortunately, the most important factors are often WHO your reviewers are and who YOU are... It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers. It can be a real difference maker if many of you join us (thousands have tried it already, but today we release a NEW and much stronger version ;) Let’s harness qed to put the power back in the scientists’ hands, to do, to read & to publish science on our own terms. I’m dying for you to TRY IT, and it’s very simple - just drop a paper (the link to the website is in the replies👇) - it’s completely secure, private, and free, and you get results fast. Please show your support, SHARE, tell your friends, and let’s be the revolution 🫵!

A super cool story from Ethan and the @OdedRechavi , O2-sensation-related, neuronal small RNAs regulate germline DNA damage and fertility in high temp!🔥

rRNA intermediates dictate nucleolar architecture in C. elegans biorxiv.org/content/10.1101/…

Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq cell.com/developmental-cell/…

Last year, we posted a preprint providing the first genetic evidence that the Harbin skull likely belonged to a Denisovan: biorxiv.org/content/10.1101/… Today, DNA evidence provided the final proof: www-sciencedirect-com.ezprox…

Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species sciencedirect.com/science/ar…

📄 New paper: "A Minimum Description Length Approach to Regularization in Neural Networks" with Orr Well, Emmanuel Chemla, @roni_katzir, and @nurikolan . We explore why neural networks often struggle with simple structured tasks. Spoiler: our regularizers might be the problem. 🧵

Flatworms, but make it high-res. 🧠🪱 This new protocol combines tissue expansion light-sheet microscopy to reveal planarian neural and muscle anatomy in 3D, at single-cell resolution. #Planaria #Microscopy #DevBio elifesciences.org/articles/1…

🔥🔥🔥OUR NEW PREPRINT: Slowing and reversing aging? Nature does it, here we show how! Age deceleration and reversal gene patterns in dauer diapause. Huge congrats to Kristy Totska, João Barata, Walter Sandt and @Meyer_DH biorxiv.org/content/10.1101/…

WOW!! A new pre-print rethinking how mosquitoes, the world's deadliest animal, mates. Amazing work from Leah @LeahHouri (former PhD student in my lab) conducted in @leslievosshall's lab. Huge implications! Leah found that contrary to what was previously thought, mosquito mating is a female-controlled process, and discovered a new active "lock and key" gating mechanism that controls mating. biorxiv.org/content/10.1101/…

Reactivation of retrotransposable elements is associated with environmental stress and ageing nature.com/articles/s41576-0…

That's dramatic (and cool): "archaea species can also form multicellular tissue–like structures when compressive forces are applied... ... These results establish multicellularity as a feature of all three domains of life"science.org/doi/10.1126/scie…

על פרסים שמתנשאים על ערבים... הייתה לנו שיחה ממש מעניינת על המון נושאים שבד"כ לא מגיעים אליהם בפודקסטים רגילים, תקשיבו! השיחה המלאה כאן: youtube.com/watch?v=OOEvbyCf…

A non-vesicular Argonaute protein is transmitted from nematode to mouse and is important for parasite survival biorxiv.org/content/10.1101/… #biorxiv_molbio

Check out this amazing pre-print: recodings of brain-wide dynamics reveal an hierarchical organization of behavior: "information about major actions is broadcast via a distributed manifold, to enable nesting of granular motor patterns within those major actions" @itamar_lev biorxiv.org/content/10.1101/…

Many congratulations to Maya Voychek and co. for crafting such a fantastic preprint ( biorxiv.org/content/10.1101/… ) and for being an outstanding community member, mentor and super mom! 1/2