Managing Director @redpoint supporting @AbridgeHQ @wearelegora @tryaugie @tryramp @getgarner @AcuityMD @scribehow / AI pod: Unsupervised Learning

Joined March 2011
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New Unsupervised Learning with Google AI researchers @NoamShazeer and @jack_w_rae on: - Scaling test-time compute - The power of the Mom eval - The pace of Open Source / DeepSeek - How AI research is where chemistry was in the 15th century - Reactions to Ilya on how far test-time compute gets us and Yann LeCun on the limits of models today - General vs. specialized models - Implications of AGI and risks YouTube: youtu.be/atMRWzgHEGg Spotify: bit.ly/3DNO2GC Apple: bit.ly/41MW2j2
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. @arimorcos on why Frontier Lab APIs might disappear:
I sat down with @arimorcos and @_RobToews for our recurring AI vibe check. We got into the tenuous future of open source models, the latest in the lab wars and some really interesting future implications of the compute crunch. It's been far too long since we did one of these and I always have fun jamming with these two. This time we hit on: ▪️ Why near-frontier open weight AI may be disappearing ▪️ Will compute constraints push labs to suspend their own APIs ▪️ Frustrations around Fable ▪️ OpenAI’s future ▪️ Where we are with Recursive Self Improvement and its implications We also hit on Cursor/xAI, ASML competitors and a ton more. 0:00 Intro 1:40 Coding Agents Cross a Threshold 3:29 Is Open-Weight AI in Retreat? 7:37 Cost Crunch & Scaffolding 12:13 The "Apps Are Cooked" Debate 16:37 Sam Altman Under Scrutiny 19:44 Anthropic's Fable Backlash 23:24 How Big a Step Change Is Fable? 26:50 What's Going On at Google? 33:20 Could the APIs Go Away? 34:11 Breaking the Semiconductor Bottleneck 35:42 Beyond EUV: Atom & X-Ray Lithography 37:23 Implications of a Compute Shortage 40:20 Do Alt Chips Actually Help? 43:43 SpaceX, xAI & the Cursor Acquisition 48:50 How Close Are We to RSI? 52:21 Quickfire YouTube: youtu.be/W_iO8XxgD_I Spotify: bit.ly/4envbk8 Apple: bit.ly/4eoD4FT
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I sat down with @arimorcos and @_RobToews for our recurring AI vibe check. We got into the tenuous future of open source models, the latest in the lab wars and some really interesting future implications of the compute crunch. It's been far too long since we did one of these and I always have fun jamming with these two. This time we hit on: ▪️ Why near-frontier open weight AI may be disappearing ▪️ Will compute constraints push labs to suspend their own APIs ▪️ Frustrations around Fable ▪️ OpenAI’s future ▪️ Where we are with Recursive Self Improvement and its implications We also hit on Cursor/xAI, ASML competitors and a ton more. 0:00 Intro 1:40 Coding Agents Cross a Threshold 3:29 Is Open-Weight AI in Retreat? 7:37 Cost Crunch & Scaffolding 12:13 The "Apps Are Cooked" Debate 16:37 Sam Altman Under Scrutiny 19:44 Anthropic's Fable Backlash 23:24 How Big a Step Change Is Fable? 26:50 What's Going On at Google? 33:20 Could the APIs Go Away? 34:11 Breaking the Semiconductor Bottleneck 35:42 Beyond EUV: Atom & X-Ray Lithography 37:23 Implications of a Compute Shortage 40:20 Do Alt Chips Actually Help? 43:43 SpaceX, xAI & the Cursor Acquisition 48:50 How Close Are We to RSI? 52:21 Quickfire YouTube: youtu.be/W_iO8XxgD_I Spotify: bit.ly/4envbk8 Apple: bit.ly/4eoD4FT
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Jacob Effron retweeted
@WSJ Exclusive: @nvidia Abridge on the first clinical conversation foundation model "Generic models are powerful, but clinical intelligence—it still has to be trained, it has to be shaped, and it has to be evaluated against real-world conditions." —@ShivdevRao, Abridge CEO and Co-Founder So many more announcements to come at today’s Abridge Keynote: events.abridge.com/keynote It’s all coming together. 12PM EDT
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Transformer co-author, @lukaszkaiser, on if big labs lose the ability to make concentrated bets as they scale to thousands of employees:
I sat down with @lukaszkaiser to get into whether the architecture he helped invent is actually enough, and what's next in generalization, coding agents, RL and more. Lukasz co-authored "Attention Is All You Need," the paper that introduced the transformer and worked on reasoning models at OpenAI so he’s been a key part of major shifts in the field. We hit on: ▪️ The case for and against a new architecture coming after the transformer ▪️ What’s required for model generalization in the physical world ▪️ How much coding agents have improved his AI research productivity ▪️ The next domains for RL ▪️ Why Anthropic initially won coding ▪️ Future research directions he’s excited about 0:00 Intro 1:12 Transformers vs. Human Learning 8:37 How Do We Get Physical World Generalization? 10:52 What Comes After Transformers 13:59 How Much Have Agents Improved Lukasz's AI Research Productivity? 17:21 How Close Is an AI Research Intern? 26:06 RL Beyond Verifiable Tasks 35:38 App Companies: Build Models or Lean on Labs? 46:21 Multimodal Is Still Missing Something 49:46 OpenAI's Bet on Reasoning 55:26 The AI Coding Wars 59:26 Focus vs. Keeping Embers Burning 1:02:09 Open Source vs. Closed Source Gap 1:05:15 Quickfire YouTube: youtu.be/N1geOimmdDo Spotify: bit.ly/4foudX0 Apple: bit.ly/4uGUhkO
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. @lukaszkaiser on hardware progress: the GPU he has under his desk today is more powerful than the entire cluster they used to train the original Transformer:
I sat down with @lukaszkaiser to get into whether the architecture he helped invent is actually enough, and what's next in generalization, coding agents, RL and more. Lukasz co-authored "Attention Is All You Need," the paper that introduced the transformer and worked on reasoning models at OpenAI so he’s been a key part of major shifts in the field. We hit on: ▪️ The case for and against a new architecture coming after the transformer ▪️ What’s required for model generalization in the physical world ▪️ How much coding agents have improved his AI research productivity ▪️ The next domains for RL ▪️ Why Anthropic initially won coding ▪️ Future research directions he’s excited about 0:00 Intro 1:12 Transformers vs. Human Learning 8:37 How Do We Get Physical World Generalization? 10:52 What Comes After Transformers 13:59 How Much Have Agents Improved Lukasz's AI Research Productivity? 17:21 How Close Is an AI Research Intern? 26:06 RL Beyond Verifiable Tasks 35:38 App Companies: Build Models or Lean on Labs? 46:21 Multimodal Is Still Missing Something 49:46 OpenAI's Bet on Reasoning 55:26 The AI Coding Wars 59:26 Focus vs. Keeping Embers Burning 1:02:09 Open Source vs. Closed Source Gap 1:05:15 Quickfire YouTube: youtu.be/N1geOimmdDo Spotify: bit.ly/4foudX0 Apple: bit.ly/4uGUhkO
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Transformer co-author, @lukaszkaiser, on why he prefers Codex:
I sat down with @lukaszkaiser to get into whether the architecture he helped invent is actually enough, and what's next in generalization, coding agents, RL and more. Lukasz co-authored "Attention Is All You Need," the paper that introduced the transformer and worked on reasoning models at OpenAI so he’s been a key part of major shifts in the field. We hit on: ▪️ The case for and against a new architecture coming after the transformer ▪️ What’s required for model generalization in the physical world ▪️ How much coding agents have improved his AI research productivity ▪️ The next domains for RL ▪️ Why Anthropic initially won coding ▪️ Future research directions he’s excited about 0:00 Intro 1:12 Transformers vs. Human Learning 8:37 How Do We Get Physical World Generalization? 10:52 What Comes After Transformers 13:59 How Much Have Agents Improved Lukasz's AI Research Productivity? 17:21 How Close Is an AI Research Intern? 26:06 RL Beyond Verifiable Tasks 35:38 App Companies: Build Models or Lean on Labs? 46:21 Multimodal Is Still Missing Something 49:46 OpenAI's Bet on Reasoning 55:26 The AI Coding Wars 59:26 Focus vs. Keeping Embers Burning 1:02:09 Open Source vs. Closed Source Gap 1:05:15 Quickfire YouTube: youtu.be/N1geOimmdDo Spotify: bit.ly/4foudX0 Apple: bit.ly/4uGUhkO
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Transformer co-author, @lukazkaiser, talks about how much agents increased his productivity in AI research::
I sat down with @lukaszkaiser to get into whether the architecture he helped invent is actually enough, and what's next in generalization, coding agents, RL and more. Lukasz co-authored "Attention Is All You Need," the paper that introduced the transformer and worked on reasoning models at OpenAI so he’s been a key part of major shifts in the field. We hit on: ▪️ The case for and against a new architecture coming after the transformer ▪️ What’s required for model generalization in the physical world ▪️ How much coding agents have improved his AI research productivity ▪️ The next domains for RL ▪️ Why Anthropic initially won coding ▪️ Future research directions he’s excited about 0:00 Intro 1:12 Transformers vs. Human Learning 8:37 How Do We Get Physical World Generalization? 10:52 What Comes After Transformers 13:59 How Much Have Agents Improved Lukasz's AI Research Productivity? 17:21 How Close Is an AI Research Intern? 26:06 RL Beyond Verifiable Tasks 35:38 App Companies: Build Models or Lean on Labs? 46:21 Multimodal Is Still Missing Something 49:46 OpenAI's Bet on Reasoning 55:26 The AI Coding Wars 59:26 Focus vs. Keeping Embers Burning 1:02:09 Open Source vs. Closed Source Gap 1:05:15 Quickfire YouTube: youtu.be/N1geOimmdDo Spotify: bit.ly/4foudX0 Apple: bit.ly/4uGUhkO
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Jacob Effron retweeted
tl;dr It’s the Age of Research Something is off about models: 1) Training is so sample inefficient 2) Very long thinking trajectories: models will do the right thing only after exhausting all other possibilities 3) Generalization is whack. Waymo can’t handle construction on highway. No teenager would have this problem. Unclear why December was an inflection point for coding agents. No single clear attributable change. Google is still pre-December on coding capabilities. 5-10x speed up in work. 3 weeks to implement paper in ye olden days. 2 days with codex can do many things in parallel. Humans see, hear, talk, everything all at once. Of course that’s how it should be for models. Big update on how quickly we got to an intern level coding agent. Didn’t expect that in 2025.
I sat down with @lukaszkaiser to get into whether the architecture he helped invent is actually enough, and what's next in generalization, coding agents, RL and more. Lukasz co-authored "Attention Is All You Need," the paper that introduced the transformer and worked on reasoning models at OpenAI so he’s been a key part of major shifts in the field. We hit on: ▪️ The case for and against a new architecture coming after the transformer ▪️ What’s required for model generalization in the physical world ▪️ How much coding agents have improved his AI research productivity ▪️ The next domains for RL ▪️ Why Anthropic initially won coding ▪️ Future research directions he’s excited about 0:00 Intro 1:12 Transformers vs. Human Learning 8:37 How Do We Get Physical World Generalization? 10:52 What Comes After Transformers 13:59 How Much Have Agents Improved Lukasz's AI Research Productivity? 17:21 How Close Is an AI Research Intern? 26:06 RL Beyond Verifiable Tasks 35:38 App Companies: Build Models or Lean on Labs? 46:21 Multimodal Is Still Missing Something 49:46 OpenAI's Bet on Reasoning 55:26 The AI Coding Wars 59:26 Focus vs. Keeping Embers Burning 1:02:09 Open Source vs. Closed Source Gap 1:05:15 Quickfire YouTube: youtu.be/N1geOimmdDo Spotify: bit.ly/4foudX0 Apple: bit.ly/4uGUhkO
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.@lukaszkaiser on why Anthropic was first to break through in coding:
I sat down with @lukaszkaiser to get into whether the architecture he helped invent is actually enough, and what's next in generalization, coding agents, RL and more. Lukasz co-authored "Attention Is All You Need," the paper that introduced the transformer and worked on reasoning models at OpenAI so he’s been a key part of major shifts in the field. We hit on: ▪️ The case for and against a new architecture coming after the transformer ▪️ What’s required for model generalization in the physical world ▪️ How much coding agents have improved his AI research productivity ▪️ The next domains for RL ▪️ Why Anthropic initially won coding ▪️ Future research directions he’s excited about 0:00 Intro 1:12 Transformers vs. Human Learning 8:37 How Do We Get Physical World Generalization? 10:52 What Comes After Transformers 13:59 How Much Have Agents Improved Lukasz's AI Research Productivity? 17:21 How Close Is an AI Research Intern? 26:06 RL Beyond Verifiable Tasks 35:38 App Companies: Build Models or Lean on Labs? 46:21 Multimodal Is Still Missing Something 49:46 OpenAI's Bet on Reasoning 55:26 The AI Coding Wars 59:26 Focus vs. Keeping Embers Burning 1:02:09 Open Source vs. Closed Source Gap 1:05:15 Quickfire YouTube: youtu.be/N1geOimmdDo Spotify: bit.ly/4foudX0 Apple: bit.ly/4uGUhkO
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Jacob Effron retweeted
Introducing Ideogram 4.0: the best open image model in the world. Think it. Make it. Own it. Download the weights, fine-tune on your own data, and run it on your hardware. Live on every Ideogram plan and the API today.
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I sat down with @lukaszkaiser to get into whether the architecture he helped invent is actually enough, and what's next in generalization, coding agents, RL and more. Lukasz co-authored "Attention Is All You Need," the paper that introduced the transformer and worked on reasoning models at OpenAI so he’s been a key part of major shifts in the field. We hit on: ▪️ The case for and against a new architecture coming after the transformer ▪️ What’s required for model generalization in the physical world ▪️ How much coding agents have improved his AI research productivity ▪️ The next domains for RL ▪️ Why Anthropic initially won coding ▪️ Future research directions he’s excited about 0:00 Intro 1:12 Transformers vs. Human Learning 8:37 How Do We Get Physical World Generalization? 10:52 What Comes After Transformers 13:59 How Much Have Agents Improved Lukasz's AI Research Productivity? 17:21 How Close Is an AI Research Intern? 26:06 RL Beyond Verifiable Tasks 35:38 App Companies: Build Models or Lean on Labs? 46:21 Multimodal Is Still Missing Something 49:46 OpenAI's Bet on Reasoning 55:26 The AI Coding Wars 59:26 Focus vs. Keeping Embers Burning 1:02:09 Open Source vs. Closed Source Gap 1:05:15 Quickfire YouTube: youtu.be/N1geOimmdDo Spotify: bit.ly/4foudX0 Apple: bit.ly/4uGUhkO
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. @scmallaby on Demis’s response to Google sitting on the transformer for years:
.@scmallaby spent 30 hours with Demis Hassabis in the back of a British pub. I sat down with Sebastian to chat about his recent book, The Infinity Machine, where he provides a fascinating history of DeepMind, Demis and the broader AI landscape. We hit on: ▪️ Whether the race between labs was inevitable ▪️ Project Mario: the secret plan to spin DeepMind out of Google ▪️ Why Google missed scaling the transformer despite inventing it and wasn’t first to ChatGPT and Claude Code ▪️ The personal history between Demis, Elon and Sam ▪️ The quasi-spiritual conviction Sebastian didn't expect to find underneath the science 0:00 Intro 2:04 Was the AI Race Inevitable? 4:03 The 2015 Safety Summit Backfire 11:27 Why Google Doesn't Make As Concentrated Bets 15:51 Project Mario: The Secret Spinout Plan 19:43 What Demis Actually Regrets 23:46 Venture Startups vs. Tech Behemoths 34:08 David Silver and the RL True Believers 38:21 Demis, Elon, and the Evil Genius Feud 42:39 Great Man Theory vs. Inevitability 45:00 What Demis Didn't Want Published YouTube: youtu.be/WC_embCiwgU Spotify: bit.ly/4wRqvLE Apple: bit.ly/4dDnnvq
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Jacob Effron retweeted
.@scmallaby spent 30 hours with Demis Hassabis in the back of a British pub. I sat down with Sebastian to chat about his recent book, The Infinity Machine, where he provides a fascinating history of DeepMind, Demis and the broader AI landscape. We hit on: ▪️ Whether the race between labs was inevitable ▪️ Project Mario: the secret plan to spin DeepMind out of Google ▪️ Why Google missed scaling the transformer despite inventing it and wasn’t first to ChatGPT and Claude Code ▪️ The personal history between Demis, Elon and Sam ▪️ The quasi-spiritual conviction Sebastian didn't expect to find underneath the science 0:00 Intro 2:04 Was the AI Race Inevitable? 4:03 The 2015 Safety Summit Backfire 11:27 Why Google Doesn't Make As Concentrated Bets 15:51 Project Mario: The Secret Spinout Plan 19:43 What Demis Actually Regrets 23:46 Venture Startups vs. Tech Behemoths 34:08 David Silver and the RL True Believers 38:21 Demis, Elon, and the Evil Genius Feud 42:39 Great Man Theory vs. Inevitability 45:00 What Demis Didn't Want Published YouTube: youtu.be/WC_embCiwgU Spotify: bit.ly/4wRqvLE Apple: bit.ly/4dDnnvq
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. @scmallaby on the personality and credentials gap that shapes how Demis Hassabis sees Sam Altman
.@scmallaby spent 30 hours with Demis Hassabis in the back of a British pub. I sat down with Sebastian to chat about his recent book, The Infinity Machine, where he provides a fascinating history of DeepMind, Demis and the broader AI landscape. We hit on: ▪️ Whether the race between labs was inevitable ▪️ Project Mario: the secret plan to spin DeepMind out of Google ▪️ Why Google missed scaling the transformer despite inventing it and wasn’t first to ChatGPT and Claude Code ▪️ The personal history between Demis, Elon and Sam ▪️ The quasi-spiritual conviction Sebastian didn't expect to find underneath the science 0:00 Intro 2:04 Was the AI Race Inevitable? 4:03 The 2015 Safety Summit Backfire 11:27 Why Google Doesn't Make As Concentrated Bets 15:51 Project Mario: The Secret Spinout Plan 19:43 What Demis Actually Regrets 23:46 Venture Startups vs. Tech Behemoths 34:08 David Silver and the RL True Believers 38:21 Demis, Elon, and the Evil Genius Feud 42:39 Great Man Theory vs. Inevitability 45:00 What Demis Didn't Want Published YouTube: youtu.be/WC_embCiwgU Spotify: bit.ly/4wRqvLE Apple: bit.ly/4dDnnvq
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.@scmallaby spent 30 hours interviewing Demis Hassabis in a British pub. He explains the thing that surprised him most:
.@scmallaby spent 30 hours with Demis Hassabis in the back of a British pub. I sat down with Sebastian to chat about his recent book, The Infinity Machine, where he provides a fascinating history of DeepMind, Demis and the broader AI landscape. We hit on: ▪️ Whether the race between labs was inevitable ▪️ Project Mario: the secret plan to spin DeepMind out of Google ▪️ Why Google missed scaling the transformer despite inventing it and wasn’t first to ChatGPT and Claude Code ▪️ The personal history between Demis, Elon and Sam ▪️ The quasi-spiritual conviction Sebastian didn't expect to find underneath the science 0:00 Intro 2:04 Was the AI Race Inevitable? 4:03 The 2015 Safety Summit Backfire 11:27 Why Google Doesn't Make As Concentrated Bets 15:51 Project Mario: The Secret Spinout Plan 19:43 What Demis Actually Regrets 23:46 Venture Startups vs. Tech Behemoths 34:08 David Silver and the RL True Believers 38:21 Demis, Elon, and the Evil Genius Feud 42:39 Great Man Theory vs. Inevitability 45:00 What Demis Didn't Want Published YouTube: youtu.be/WC_embCiwgU Spotify: bit.ly/4wRqvLE Apple: bit.ly/4dDnnvq
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Reid Hoffman pledged $1B to back a secret DeepMind spinout from Google. Demis Hassabis used the leverage to pressure Google on safety oversight, but never told them the money existed and never exercised the threat. @scmallaby uncovered the story in his new book:
.@scmallaby spent 30 hours with Demis Hassabis in the back of a British pub. I sat down with Sebastian to chat about his recent book, The Infinity Machine, where he provides a fascinating history of DeepMind, Demis and the broader AI landscape. We hit on: ▪️ Whether the race between labs was inevitable ▪️ Project Mario: the secret plan to spin DeepMind out of Google ▪️ Why Google missed scaling the transformer despite inventing it and wasn’t first to ChatGPT and Claude Code ▪️ The personal history between Demis, Elon and Sam ▪️ The quasi-spiritual conviction Sebastian didn't expect to find underneath the science 0:00 Intro 2:04 Was the AI Race Inevitable? 4:03 The 2015 Safety Summit Backfire 11:27 Why Google Doesn't Make As Concentrated Bets 15:51 Project Mario: The Secret Spinout Plan 19:43 What Demis Actually Regrets 23:46 Venture Startups vs. Tech Behemoths 34:08 David Silver and the RL True Believers 38:21 Demis, Elon, and the Evil Genius Feud 42:39 Great Man Theory vs. Inevitability 45:00 What Demis Didn't Want Published YouTube: youtu.be/WC_embCiwgU Spotify: bit.ly/4wRqvLE Apple: bit.ly/4dDnnvq
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Garner Health is one of the fastest growing and under-the-radar companies in tech. On the heels of their Series E, @nikillinit and I talked with @nickpreber to dig into how @getgarner reached this scale and what comes next. We’ve had the privilege of working closely with Nick for five years now and I think you’ll see in this conversation what makes him such a special entrepreneur. He’s had a consistently clear vision for improving US healthcare and relentlessly executed to do so. He’s incredibly thoughtful about how AI and data can be effectively used and we got into a lot of details around Garner’s approach to both. Full episode below: YouTube: youtu.be/I92TlMES_TY Spotify: bit.ly/3Ry7EVW
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Garner is a special company with an incredible team. Excited to work with our friends at Index and for everything ahead!
Excited to announce @getgarner has raised $100M at a $2.74B valuation. 2.5M beneficiaries. 800 employers. $1B saved for our customers. 12% lower plan costs on average. With this funding, we continue to build the new AI front door to healthcare - starting with two new features that we are announcing today that transform our member experience and accelerate our understanding of clinical performance: Garner Assistant and Garner Research Agent. Grateful to @ikeswetlitz and @Bloomberg for covering our story! bloomberg.com/news/articles/…
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