Congratulations to
@LauraBukavinaMD @jaymsiva @drjkaouk and
@ClevelandClinic team on largest external validation of the IBCG IR NMIBC substratification model
π 2822 patients | 20 years | 3-year recurrence by subgroup:
π’ IR-low: 12%
π‘ IR-intermediate: 38%
π΄ IR-high: 77%
Progression followed the same stepwise pattern. Fine-Gray competing-risk models confirmed significance (p<0.001) - separation held on 12-month landmark analysis, ruling out early-event bias.
Yet more evidence that trials enrolling IR NMIBC should stratify by IBCG subgroup at enrollment to be clinically meaningful.
Conflating patients with 12% and 77% recurrence risk in the same trial arm is a fundamental problem.
Full text:
authors.elsevier.com/sd/arti⦠@IBCG_BladderCA