Joined November 2010
- Tweets 40
- Following 334
- Followers 56
- Likes 313
8 Photos and videos
Pinned Tweet
13 Jan 2023
Our article has been published in Nature Communications! Thank you to the editors, reviewers, and my co-authors @EngelTatiana @anne_churchland for a thoughtful and thorough editorial process. The updated article is available at rdcu.be/c278F
26 Jan 2022
In decision-making tasks excitatory and inhibitory neurons show selectively for an upcoming choice. @EngelTatiana, @anne_churchland, and I explore the effects of inhibitory choice selectivity in decision making circuits using mean-field and RNN models. biorxiv.org/content/10.1101/…
5
21
5,055
James Patrick Roach retweeted
19 Jul 2022
Excited to share our new preprint on how network dynamics and structured connectivity jointly define the spatial and temporal profiles of neural correlations. Work w/ @roxana_zeraati, @SelfOrgAnna, @EngelTatiana: arxiv.org/abs/2207.07930 Here is a #tweeprint:
1
20
78
26 Jan 2022
While choice selective inhibition can enhance a competitive or stabilizing role, which of these roles dominates in the circuit is controlled by factors beyond the specificity of inhibitory connections, such as inhibitory tone.
1
3
26 Jan 2022
Our models predict that in different regimes circuits have divergent responses to perturbations of inhibitory neurons: when competitive inhibition dominates suppressing inhibition will slow decisions, whereas decisions will be faster when stabilizing inhibition dominates.
2
26 Jan 2022
In decision-making tasks excitatory and inhibitory neurons show selectively for an upcoming choice. @EngelTatiana, @anne_churchland, and I explore the effects of inhibitory choice selectivity in decision making circuits using mean-field and RNN models. biorxiv.org/content/10.1101/…
2
17
58
26 Jan 2022
In RNNs trained to perform a decision-making task, connections between choice selective units had the same relationship between the specificity of recurrent excitation and whether selective inhibition was contraspecific or ipsispecific.
1
3
26 Jan 2022
The two alternative roles for inhibition—competitive or stabilizing—are apparent in the performance of the circuits. Ipsispecific inhibition leads to slow, accurate decisions while contraspecific inhibition leads to faster decisions at the expense of accuracy.
1
1
6
26 Jan 2022
The specificity of inhibitory connections can compensate for the specificity of excitation: when inhibition is contraspecific, weakly specific excitatory circuits can make decisions and when inhibition is ipsispecific, strongly specific excitatory circuits support decisions.
1
1
3
26 Jan 2022
We constructed circuit models with excitatory and inhibitory populations selective for one of two choices. We connect inhibitory outputs in either contraspecific (across choice) or ipsispecific (within choice) motif.
1
2
11
James Patrick Roach retweeted
25 Jan 2022
Excited to share our bioRxiv preprint with @EngelTatiana.
Cortical neurons show mixed selectivity for multiple task variables. We develop a latent circuit model for inferring interpretable circuit mechanisms from heterogeneous neural responses.
biorxiv.org/content/10.1101/…
1
11
36
James Patrick Roach retweeted
5 Feb 2021
It's our 5 month anniversary @dgsomucla! Been a wild & busy time. We got all the setups running; biggest problem is optimizing data management workflows (bless rclone). Movie w/ triple labelling to target inhib neurons by @jpatrickroach & @joaoaocouto w/our new @neurolabware 2p!!
2
6
51
James Patrick Roach retweeted
5 Jan 2021
Excited to share our arXiv preprint with @owenkhughes and @EngelTatiana. We develop a framework for inferring non-stationary Langevin dynamics from stochastic observations and test it on spike data generated from decision-making models.
Link: arxiv.org/abs/2012.14944
1
3
14
James Patrick Roach retweeted
22 Oct 2019
Can we trust interpretation of machine-learning models that are good at predicting data? Our preprint on @biorxiv_neursci shows that good data prediction and accurate interpretation of the model are not the same. biorxiv.org/content/10.1101/…
3
64
198
9 Aug 2018
Simplified neural encoding of social communication reflects lifestyle biorxiv.org/content/early/20…
2
James Patrick Roach retweeted
12 Jun 2018
Best Game Day Fan Experience
• College Football Elite 8
RT ~ Michigan
Like ~ Penn State
#BracketBattles
10
1,215
1,497
James Patrick Roach retweeted
7 Jun 2018
I want to hire a #postdoc in the coming months! If you are interested in joining a fantastic and collaborative team to explore the neural circuitry underlying individual differences in motivated behaviors, contact me (sflagel@umich.edu). More info: flagel.lab.medicine.umich.ed… Pls RT!
1
91
59
15 Mar 2018
My latest paper is now available online! Check it out.
Resonance with subthreshold oscillatory drive organizes activity and optimizes learning in neural networks pnas.org/content/early/2018/…
1
2
4
James Patrick Roach retweeted
11 Dec 2017
#MuppetChristmasCarol is 25 today! To celebrate, I've got my Charles Dickens costume and I'm narrating the lives of random passersby!
59
1,253
3,194
James Patrick Roach retweeted
2 Dec 2017
@ryangrim:
This bill gets talked about as a $1.5 trillion tax cut. It’s not. It is a $6 trillion tax cut for some people paid for by a $4.5 trillion tax hike on other people.
That makes it the biggest tax hike in American history.
bit.ly/2BC9IAL #TaxScam
31
757
905