Associate Professor at UPenn
Joined March 2013
- Tweets 417
- Following 512
- Followers 1,073
- Likes 1,057
5 Photos and videos
Pinned Tweet
Apr 17
One more thing. Another work led by the dedicated and talented scientists @DiqiuR and Shangshang Wang, stemming from our long-standing collaboration with Rahul Kohli and @andyjminn’s labs at Penn.
nature.com/articles/s41587-0…
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Junwei Shi retweeted
May 18
Very excited to get this new work by Shin Ngiow up on #bioRxiv. We may be blocking PD-1 too long causing detrimental effects on Tpex cells. A drug holiday approach may be beneficial. Also some cool new Tpex biology here. #immunopharmacology biorxiv.org/content/10.64898…
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Junwei Shi retweeted
Inducible, split base editors for in vivo cancer functional genomics go.nature.com/4tfu1xi
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Apr 17
One more thing. Another work led by the dedicated and talented scientists @DiqiuR and Shangshang Wang, stemming from our long-standing collaboration with Rahul Kohli and @andyjminn’s labs at Penn.
nature.com/articles/s41587-0…
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Apr 17
A high-resolution tiling base editing mutagenesis screen targeting Adar1, an adenosine deaminase associated with tumor immunity, identified both loss-of-function and gain-of-function alleles.
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Apr 17
Our improved, inducible base editing system (seBE) provides controllable and robust genome editing to systematically identify functionally relevant key residues for cancer functional genomics.
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Apr 17
Have been missing twitter. Excited to share our new study. This was a close collaboration with Kathrin Bernt's and @KaiTanLab1 labs, led by the talented and unstoppable @TomZhendong and Sixiang Yu
cell.com/molecular-cell/full…
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Apr 17
CRISPR knockout screens reveal both shared and distinct AML dependencies in primary samples. CRISPRi screens identify essential cis-regulatory elements in PDXs. We further used Perturb-seq to dissect regulatory networks and cellular heterogeneity in primary AML cells.
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Apr 17
This robust and general CRISPR-based functional genomics approach in primary AML patient samples opens up new opportunities to prioritize/identify therapeutic targets and understand resistance mechanisms in AML.
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Junwei Shi retweeted
Mar 20
ft. @TomZhendong, S. Yu, Y. Liu, L. Liu, @junwei_s (@Penn_CBIO/ @PennEpiInst), @jackiejpeng (@UPennGCB), D. Barrett, J. Sussman, C. Chen, A. Thadi, F. Alikarami, J. Xu, @cdktmw, @kathrinbernt (@CHOP_Research) & Martin Carroll (@PennCancer) @CAMBUpenn cell.com/molecular-cell/full…
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Junwei Shi retweeted
Healthy blood cells can live without ARHGAP45—but acute myeloid leukemia cells can’t. 🩸 Junwei Shi, PhD, Associate Professor of Cancer Biology (@junwei_s) and team show a CAR T CDC42 inhibition strategy could target AML with minimal side effects. bit.ly/45OyXQu
ALT Healthy blood cells and cancer cells illustration.
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Junwei Shi retweeted
22 Sep 2025
Systematic evaluation of GAPs and GEFs identifies a targetable dependency for hematopoietic malignancies ft. Yuqiao Liu & @junwei_s (@Penn_CBIO) @CD_AACR aacrjournals.org/cancerdisco…
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13 Aug 2025
Excited to share our new study, in close collaboration with @AbdelWahablab and @DaniyanMd led by the exceptionally talented scientists @PuZhang09980432 and @TomZhendong
doi.org/10.1158/2159-8290.CD…
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13 Aug 2025
Even more exciting: CDC42 inhibition not only synergizes with ARHGAP45 loss intrinsically in leukemia cells, but also enhances TCR-CAR T cell function. A dual strategy to target cancer cells and augment immune responses.
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13 Aug 2025
This has truly been a fantastic collaboration that I can only dream of @AbdelWahablab, @DaniyanMd, @TomZhendong, and @PuZhang09980432
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13 Aug 2025
This has truly been a fantastic collaboration that I can only dream of @AbdelWahablab, @DaniyanMd, @TomZhendong, and @PuZhang09980432
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