@lab_plotkin profile picture
PlotkinLab @lab_plotkin

Our lab is focused on elucidating the brain circuit alterations that underlie OCD related behaviors, and the mechanisms guiding normal basal ganglia function.

Joined August 2018
  • Tweets 146
  • Following 106
  • Followers 214
9 Photos and videos
Congrats Josh and colleagues!! Great paper!!!
Josh Goldberg Lab ๐Ÿ‡ฎ๐Ÿ‡ฑ๐Ÿ’”@GoldbergLab
15 Sep 2025
Levodopa Disrupts Activity Patterns and Encoding of Movement in Striatal Cholinergic Interneurons of Behaving Mice - Atamna - Movement Disorders - Wiley Online Library movementdisorders.onlinelibrโ€ฆ
1
1
212
Levodopa Disrupts Activity Patterns and Encoding of Movement in Striatal Cholinergic Interneurons of Behaving Mice - Atamna - Movement Disorders - Wiley Online Library movementdisorders.onlinelibrโ€ฆ

Levodopa Disrupts Activity Patterns and Encoding of Movement in Striatal Cholinergic Interneurons...

Objectives Levodopa treatment, the gold standard therapy for Parkinson's disease, can lead to levodopa-induced dyskinesias (LIDs). Recent studies in acute brain slices have implicated the neural...

movementdisorders.onlinelibrary.wiley.com
3
5
9
883
We are excited to announce that applications for this year's BRITE seminar series are now open! Access the application here: bit.ly/4lTzeWY
1
8
6
1,091
Congrats and thanks to @MatityahuLior , Zach Hobel, Jeff Malgady, Noa Berkowitz and Naomi Gilin for the hard work and great ideas!!!
Josh Goldberg Lab ๐Ÿ‡ฎ๐Ÿ‡ฑ๐Ÿ’”@GoldbergLab
4 Nov 2024
New preprint w/ @lab_plotkin about cholinergic interneurons causing local serotonin release in striatum and how this is related to obsessive-compulsive disorder biorxiv.org/content/10.1101/โ€ฆ For the story, read on 1/9
2
10
623
Therapeutic targeting of senescent cells in the CNS pubmed.ncbi.nlm.nih.gov/3934โ€ฆ Excellent review by @RiesslandLab and colleagues!

Therapeutic targeting of senescent cells in the CNS - PubMed

Senescent cells accumulate throughout the body with advanced age, diseases and chronic conditions. They negatively impact health and function of multiple systems, including the central nervous system...

pubmed.ncbi.nlm.nih.gov
1
1
206
Please consider supporting this important cause if you can
1
1
212
Congratulations to Dr. Zach Hobel, who beautifully defended his dissertation!!! Well done!!! The lab and I are so proud of everything you've accomplished!
2
12
636
Please share! The applications are open for this year's BRITE postdoctoral seminar series! We are excited to host three postdoctoral researchers to present their work with us here at SBU.
13
8
3,493
Ion channel dysregulation and cellular adaptations to alpha-synuclein in stressful pacemakers of the parkinsonian bโ€ฆ pubmed.ncbi.nlm.nih.gov/3895โ€ฆ

Ion channel dysregulation and cellular adaptations to alpha-synuclein in stressful pacemakers of...

Parkinson's disease (PD) is diagnosed by its cardinal motor symptoms that are associated with the loss of dopamine neurons in the substantia nigra pars compacta (SNc). However, PD patients suffer...

pubmed.ncbi.nlm.nih.gov
1
100
Phase delays between mouse globus pallidus neurons entrained by common oscillatory drive arise from their intrinsic properties, not their coupling biorxiv.org/content/10.1101/โ€ฆ

Phase delays between mouse globus pallidus neurons entrained by common oscillatory drive arise from...

A hallmark of Parkinsonโ€™s disease is the appearance of correlated oscillatory discharge throughout the cortico-basal ganglia (BG) circuits. In the primate globus pallidus (GP), where the discharge of...

biorxiv.org
1
1
209
GPe neurons are uncorrelated, but in PD become oscillatory & correlated, allegedly disrupting independent channels thru the basal ganglia. Our new preprint, w/ the Wilson lab, shows how phase response curves of independent GP neurons driven by sinusoids predict these correlations
Josh Goldberg Lab ๐Ÿ‡ฎ๐Ÿ‡ฑ๐Ÿ’”@GoldbergLab
20 Feb 2024
Phase delays between mouse globus pallidus neurons entrained by common oscillatory drive arise from their intrinsic properties, not their coupling biorxiv.org/content/10.1101/โ€ฆ
4
11
1,754
Great work, once again, from @GoldbergLab and @LTiroshi !!!
LiorTiroshi@LTiroshi
11 Dec 2023
Iโ€™m thrilled to share that our latest research, unveiling the unreliability of striatal neural responses through a unique application of sparse labeling, has been officially published! eneuro.org/content/early/202โ€ฆ @SfNJournals @Yara_Atamna @GoldbergLab @Hujimed Key findings ๐Ÿงต
5
226
Acetylcholine waves and dopamine release in the striatum disq.us/t/4jwiblq
3
145
Applications are open until Oct 2- great opportunity for postdocs!! Please consider applying, and help spread the word! forms.gle/PH9YfqrGWAihuJpM8

Stony Brook Department of Neurobiology & Behavior@SBUNeurobiology
17 Aug 2023
Great opportunity for postdocs!! We are accepting applications for this year's BRITE (Bolstering Research through Inclusion, Talent, and Excellence) Postdoctoral Seminar Series! The goal is to enhance inclusion in neuroscience research. Please RT. forms.gle/PH9YfqrGWAihuJpM8
195
Great opportunity for postdocs!! @SBUNeurobiology is accepting applications for this year's BRITE (Bolstering Research through Inclusion, Talent and Excellence) Postdoctoral Seminar Series! The goal is to enhance inclusion in neuroscience research. forms.gle/PH9YfqrGWAihuJpM8
3
4
712
PlotkinLab retweeted
bioRxiv@biorxivpreprint
21 Jul 2023
The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons biorxiv.org/cgi/content/shorโ€ฆ #bioRxiv
3
4
2,185
๐ŸŽ‰ The Thomas Hartman Applications for 2023 are closed! Congrats to our amazing award recipients: Dr. Joshua Plotkin, Dr. Markus Riessland (with Co-Pis Dr. Joshua Plotkin & Dr. Lonnie Wollmuth), Dr. Mary Kritzer (with Co-Pi Dr. Daniel Davis), and Dr. Irene Solomon. #HartmanAward
1
9
582
Woohoo! Congrats to Felicia Yang for winning Best Poster at the SoM Women in Medicine Research Day! ๐ŸŽ‰๐Ÿ‘ฉโ€๐Ÿ”ฌ Well done and keep up the great work! #womeninmedicine
1
5
673
Either the university installed new air vents on our labโ€™s building or weโ€™re about to be attacked by Mandalorians! Not sure which to root for!
1
6
2,058
PlotkinLab retweeted
bioRxiv Neuroscience@biorxiv_neursci
7 Nov 2022
Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens biorxiv.org/cgi/content/shorโ€ฆ #biorxiv_neursci
10
39
Load more