A Systems Biologist with passion for research, photograph, and cook.
Joined December 2009
- Tweets 189
- Following 183
- Followers 85
- Likes 203
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Apr 21
📢 Call for Papers!
Our new Research Topic "Scalable and Interpretable Visual Analytics for Big Data" is now open for submissions in Frontiers in Bioinformatcs! 🧬💻
🗓️ Deadline: Nov 7, 2026
🔗 Submit here: frontiersin.org/research-top…
#Bioinformatics #DataViz #BigData
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🚨Paper submissions to iscbAI are due tomorrow, Monday, June 1!
📥 Submit here: iscb-cn.org.cn/web/72/list.h…
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May 17
New research in @CMLS_Journal provides the first systematic look at SOX10-mediated miRNA regulation in Uveal Melanoma (UM).
🔗 Read the full study here: rdcu.be/fjbeA
#UvealMelanoma #CancerResearch #SystemsBiology #miRNA #Bioinformatics #Oncology #PrecisionMedicine
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13 Dec 2025
The latest research from Guo's lab at @theNCI shows that one hotspot mutation in #DICER1's RNase IIIb can lead to loss and gain of function 5p-miRNA and the gain of function of 3p-miRNA.
rdcu.be/eUxiq
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22 Oct 2025
See our new preprint, where we used a network biology method to identify novel therapeutic targets for uveal #melanoma.
#networkmedicine #bioinformatics #cancer
15 Oct 2025
A computational SOX10 network-based selection strategy to identify new drug targets in uveal melanoma biorxiv.org/content/10.1101/… #biorxiv_cancer
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18 Oct 2025
Seedless binding in #miRNAs can also lead to gene repression as shown with miR-155 and miR-124, though this unconventional binding accounts ~1% of miRNA binding. See Bartel lab's new paper for details.
Functional microRNA targeting without seed pairing academic.oup.com/nar/article…
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3 Oct 2025
New preprint on IDH-mutant #astrocytomas: We analyzed rare patient samples showing grade 2-3→4 progression post-therapy. Key findings: #ncRNAs drive astrocyte dedifferentiation; tumor suppressor #miRNA let-7b-3p shows recurrent deletions; #lncRNA NEAT1 regulates ECM organization
2 Oct 2025
Integrative multi-modal analysis reveals the contribution of noncoding RNAs to post-treatment progression of IDH-mutant astrocytomas biorxiv.org/content/10.1101/… #biorxiv_cancer
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3 Sep 2025
New publication at #Bioinformatics of @OxfordJournals.
HallmarkGraph: a cancer hallmark informed graph neural network for classifying hierarchical tumor subtypes
#CancerResearch #MachineLearning #AIinMedicine #PrecisionOncology
academic.oup.com/bioinformat…
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3 Sep 2025
We built HallmarkGraph to be transparent. By integrating gene-level features with cancer hallmarks, we can now provide clear explanations for our model's predictions. #InterpretableAI #ComputationalOncology #MedicalAI
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3 Sep 2025
Our commitment to open science means the HallmarkGraph data and code are publicly available on #GitHub and #Zenodo.
#OpenScience #FAIRdata #Research #GitHub #DataSharing
github.com/laixn/HallmarkGra…
doi.org/10.5281/zenodo.15790…
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22 Aug 2025
The 2nd China-Germany-Finland Life Sciences Forum, held at Tampere University, has successfully concluded. The forum brought together 60 researchers from five countries. The forum focused on AI in biomedical research and health data science innovation.
tuni.fi/en/news/internationa…
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22 Aug 2025
The second day's session on the digitization of health benefited greatly from the participation of high-level government officials and Chinese and Finnish companies, including @avaintec , @AtostekOy , SOENIA®, @NADMED_Ltd, 神州医疗.
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22 Aug 2025
The forum's emphasis on translating academic research into practical applications through industry partnerships reflects the urgent need for scalable, data-driven healthcare solutions that can be deployed globally to improve patient outcomes and population health management.
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Xin Lai retweeted
Just published!🦠
Repurposed #clindamycin suppresses #pyroptosis in tumor-associated macrophages through Inhibition of caspase-1
Open access🔓
jeccr.biomedcentral.com/arti…
#DrugRepurposing
#TumorAssociatedMacrophages
#Immunotherapy
#UvealMelanoma
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10 Aug 2025
🧬 Successfully organized #ISBRA2025 in @helsinkiuni with @NetPharMed! 167 submissions across #bioinformatics & #computationalbiology → 66 high-quality papers selected for #LNBI proceedings. Thanks to all participants for making this international symposium exceptional! 🇫🇮
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